دورية أكاديمية
Mass Spectral Library for DNA Adductomics.
| العنوان: | Mass Spectral Library for DNA Adductomics. |
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| المؤلفون: | Walmsley SJ; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States., Guo J; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Thermo Fisher Scientific, San Jose, California 95134, United States., Tarifa A; Forensic & Analytical Toxicology Facility, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States., DeCaprio AP; Forensic & Analytical Toxicology Facility, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States., Cooke MS; Oxidative Stress Group, Department of Molecular Biosciences, University of South Florida, Tampa, Florida 33620, United States., Turesky RJ; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States., Villalta PW; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.; Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States. |
| المصدر: | Chemical research in toxicology [Chem Res Toxicol] 2024 Feb 19; Vol. 37 (2), pp. 302-310. Date of Electronic Publication: 2024 Jan 17. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: Washington, DC : American Chemical Society, c1988- |
| مواضيع طبية MeSH: | DNA Adducts* , DNA*/chemistry, Humans ; Mass Spectrometry ; DNA Damage ; Carcinogenesis |
| مستخلص: | Endogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals present in the environment and diet can damage DNA by forming covalent adducts. DNA adducts can form in critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to the onset of cancer. The detection and quantification of specific DNA adducts are some of the first steps in studying their role in carcinogenesis, the physiological conditions that lead to their production, and the risk assessment of exposure to specific genotoxic chemicals. Hundreds of different DNA adducts have been reported in the literature, and there is a critical need to establish a DNA adduct mass spectral database to facilitate the detection of previously observed DNA adducts and characterize newly discovered DNA adducts. We have collected synthetic DNA adduct standards from the research community, acquired MS n ( n = 2, 3) fragmentation spectra using Orbitrap and Quadrupole-Time-of-Flight (Q-TOF) MS instrumentation, processed the spectral data and incorporated it into the MassBank of North America (MoNA) database, and created a DNA adduct portal Web site (https://sites.google.com/umn.edu/dnaadductportal) to serve as a central location for the DNA adduct mass spectra and metadata, including the spectral database downloadable in different formats. This spectral library should prove to be a valuable resource for the DNA adductomics community, accelerating research and improving our understanding of the role of DNA adducts in disease. |
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| معلومات مُعتمدة: | R03 ES031188 United States ES NIEHS NIH HHS; P30 CA077598 United States CA NCI NIH HHS; R50 CA211256 United States CA NCI NIH HHS; R01 ES030557 United States ES NIEHS NIH HHS; R01 ES030765 United States ES NIEHS NIH HHS |
| المشرفين على المادة: | 0 (DNA Adducts) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20240117 Date Completed: 20240220 Latest Revision: 20240325 |
| رمز التحديث: | 20240326 |
| مُعرف محوري في PubMed: | PMC10939812 |
| DOI: | 10.1021/acs.chemrestox.3c00302 |
| PMID: | 38231175 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-5010 |
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| DOI: | 10.1021/acs.chemrestox.3c00302 |