دورية أكاديمية
أعرض في EDS

Cerebrospinal fluid and plasma ascorbate concentrations following subarachnoid haemorrhage.

التفاصيل البيبلوغرافية
العنوان: Cerebrospinal fluid and plasma ascorbate concentrations following subarachnoid haemorrhage.
المؤلفون: Turner N; Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia., Farrow B; Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia., Betrie AH; Pre-clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria 3052, Australia.; Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, Health, Melbourne, Victoria 3052, Australia., Finnis ME; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia.; Intensive Care Unit Research, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia., Lankadeva YR; Pre-clinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria 3052, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia., Sharman J; Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia., Tan P; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia.; Department of Anaesthesia, The Royal Women's Hospital, Grattan Street & Flemington Road, Melbourne, Victoria 3052, Australia., Abdelhamid YA; Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia., Deane AM; Intensive Care Unit, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia.; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia., Plummer MP; Department of Critical Care, Melbourne Medical School, University of Melbourne, Melbourne, Victoria 3010, Australia.; Intensive Care Unit Research, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.
المصدر: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine [Crit Care Resusc] 2023 Nov 22; Vol. 25 (4), pp. 175-181. Date of Electronic Publication: 2023 Nov 22 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V. on behalf of College of Intensive Care Medicine of Australia and New Zealand Country of Publication: Netherlands NLM ID: 100888170 Publication Model: eCollection Cited Medium: Print ISSN: 1441-2772 (Print) Linking ISSN: 14412772 NLM ISO Abbreviation: Crit Care Resusc Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : [Amsterdam] : Elsevier B.V. on behalf of College of Intensive Care Medicine of Australia and New Zealand
Original Publication: Bedford Park, S. Aust. : Australasian Academy of Critical Care Medicine, c1999-
مستخلص: Background: Ascorbate, the biologically active form of vitamin C, is the primary neural anti-oxidant. Ascorbate concentrations have never been quantified following aneurysmal subarachnoid haemorrhage (aSAH).
Objective: To quantify plasma and cerebrospinal fluid (CSF) ascorbate concentrations in patients following SAH.
Design Setting Participants Main Outcome Measures: Cohort study in which plasma and CSF ascorbate concentrations were measured longitudinally in 12 aSAH patients admitted to a quaternary referral intensive care unit and compared to one-off samples obtained from 20 pregnant women prior to delivery in a co-located obstetric hospital. Data are median [interquartile range] or median (95 % confidence intervals).
Results: Forty-eight plasma samples were obtained from the 12 aSAH patients (eight females, age 62 [53-68] years). Eight participants with extra-ventricular drains provided 31 paired CSF-plasma samples. Single plasma and CSF samples were obtained from 20 pregnant women (age 35 [31-37] years). Initial plasma and CSF ascorbate concentrations post aSAH were less than half those in pregnant controls (plasma: aSAH: 31 [25-39] μmol/L vs. comparator: 64 [59-77] μmol/L; P < 0.001 and CSF: 116 [80-142] μmol/L vs. 252 [240-288] μmol/L; P < 0.001). Post aSAH there was a gradual reduction in the CSF:plasma ascorbate ratio from ∼4:1 to ∼1:1. Six (50 %) patients developed vasospasm and CSF ascorbate concentrations were lower in these patients (vasospasm: 61 (25, 97) vs. no vasospasm: 110 (96, 125) μmol/L; P = 0.01).
Conclusion: Post aSAH there is a marked reduction in CSF ascorbate concentration that is most prominent in those who develop vasospasm.
Competing Interests: The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Yugeesh R Lankadeva has patent issued to Yugeesh R Lankadeva. Both Adam M Deane and Mark P Plummer are appointed as associate editors for CCR journal (voluntary role).
(© 2023 The Authors.)
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فهرسة مساهمة: Keywords: Ascorbate; Cerebrospinal fluid; Intracranial vasospasm; Pregnancy; Subarachnoid haemorrhage
تواريخ الأحداث: Date Created: 20240118 Latest Revision: 20240119
رمز التحديث: 20240119
مُعرف محوري في PubMed: PMC10790009
DOI: 10.1016/j.ccrj.2023.10.003
PMID: 38234324
قاعدة البيانات: MEDLINE
الوصف
تدمد:1441-2772
DOI:10.1016/j.ccrj.2023.10.003