دورية أكاديمية
أعرض في EDS

Thalamo-cortical evoked potentials during stimulation of the dentato-rubro-thalamic tract demonstrate synaptic filtering.

التفاصيل البيبلوغرافية
العنوان: Thalamo-cortical evoked potentials during stimulation of the dentato-rubro-thalamic tract demonstrate synaptic filtering.
المؤلفون: Conner CR; Division of Neurosurgery, Department of Surgery, University of Connecticut, Hartford, CT, USA. Electronic address: chconner@uchc.edu., Forseth KJ; Division of Neurosurgery, University of California San Diego, San Diego, CA, USA., Lozano AM; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Ritter R 3rd; Department of Neurosurgery, University of Texas Health Sciences Center at Houston, Houston, TX, USA., Fenoy AJ; Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Feinstein Institutes for Medical Research, Manhasset, NY, USA. Electronic address: afenoy@northwell.edu.
المصدر: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2024 Jan; Vol. 21 (1), pp. e00295. Date of Electronic Publication: 2023 Dec 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [New York] : Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics
Original Publication: Orlando, FL : Elsevier, c2007-
مواضيع طبية MeSH: Essential Tremor*/therapy , Deep Brain Stimulation*, Humans ; Neural Pathways ; Thalamus ; Evoked Potentials
مستخلص: Essential tremor DBS targeting the ventral intermediate nucleus (Vim) of the thalamus and its input, the dentato-rubro-thalamic tract (DRTt), has proven to be an effective treatment strategy. We examined thalamo-cortical evoked potentials (TCEPs) and cortical dynamics during stimulation of the DRTt. We recorded TCEPs in primary motor cortex during clinical and supra-clinical stimulation of the DRTt in ten essential tremor patients. Stimulation was varied over pulse amplitude (2-10 ​mA) and pulse width (30-250 ​μs) to allow for strength-duration testing. Testing at clinical levels (3 ​mA, 60 ​μs) for stimulation frequencies of 1-160 ​Hz was performed and phase amplitude coupling (PAC) of beta phase and gamma power was calculated. Primary motor cortex TCEPs displayed two responses: early and all-or-none (<20 ​ms) or delayed and charge-dependent (>50 ​ms). Strength-duration curve approximation indicates that the chronaxie of the neural elements related to the TCEPs is <200 ​μs. At the range of clinical stimulation (amplitude 2-5 ​mA, pulse width 30-60 ​μs), TCEPs were not noted over primary motor cortex. Decreased pathophysiological phase-amplitude coupling was seen above 70 ​Hz stimulation without changes in power spectra and below the threshold of TCEPs. Our findings demonstrate that DRTt stimulation within normal clinical bounds does not excite fibers directly connected with primary motor cortex but that supra-clinical stimulation can excite a direct axonal tract. Both clinical efficacy and phase-amplitude coupling were frequency-dependent, favoring a synaptic filtering model as a possible mechanism of action.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: Eur J Neurosci. 2000 Dec;12(12):4573-7. (PMID: 11122371)
Neurosurgery. 2014 Dec;75(6):657-69; discussion 669-70. (PMID: 25161000)
J Neurosci Methods. 2000 Apr 1;97(1):45-50. (PMID: 10771074)
J Neural Eng. 2016 Apr;13(2):021001. (PMID: 26792176)
Neuroimage. 2018 Aug 1;176:364-371. (PMID: 29733955)
Stereotact Funct Neurosurg. 2020;98(4):220-240. (PMID: 32403112)
Mol Membr Biol. 2002 Oct-Dec;19(4):293-300. (PMID: 12512776)
Comput Biomed Res. 1996 Jun;29(3):162-73. (PMID: 8812068)
Cereb Cortex. 2004 Jan;14(1):11-22. (PMID: 14654453)
Electroencephalogr Clin Neurophysiol. 1990 May;75(5):371-7. (PMID: 1692272)
Brain Stimul. 2015 Jan-Feb;8(1):42-56. (PMID: 25457213)
Mov Disord. 2002 Sep;17(5):969-83. (PMID: 12360546)
Science. 2006 Sep 15;313(5793):1626-8. (PMID: 16973878)
J Neurophysiol. 2010 Aug;104(2):1195-210. (PMID: 20463205)
J Neurosci Methods. 2005 Feb 15;141(2):171-98. (PMID: 15661300)
Neurotherapeutics. 2008 Jan;5(1):14-25. (PMID: 18164480)
Neuroimage. 2013 Jan 1;64:416-24. (PMID: 22986076)
Brain Stimul. 2021 May-Jun;14(3):549-563. (PMID: 33757931)
Prog Neurobiol. 2011 Sep 1;94(4):307-46. (PMID: 21708220)
Lancet. 1980 Jun 7;1(8180):1221-2. (PMID: 6104038)
Nat Rev Neurol. 2019 Mar;15(3):148-160. (PMID: 30683913)
Comput Biol Med. 2011 Dec;41(12):1100-9. (PMID: 21851933)
PLoS One. 2013 Sep 16;8(9):e73456. (PMID: 24066049)
Neuroimage. 1999 Feb;9(2):179-94. (PMID: 9931268)
Nat Rev Neurosci. 2012 May 18;13(6):407-20. (PMID: 22595786)
Brain Res. 1975 Nov 21;98(3):417-40. (PMID: 1102064)
Brain. 2009 Aug;132(Pt 8):2139-50. (PMID: 19369488)
J Neurosurg. 2014 Jan;120(1):132-9. (PMID: 24236657)
Annu Rev Neurosci. 2006;29:229-57. (PMID: 16776585)
Nat Neurosci. 2015 May;18(5):779-86. (PMID: 25867121)
J Neurosci. 2018 Oct 24;38(43):9129-9141. (PMID: 30201770)
Neuron. 2020 May 20;106(4):579-588.e3. (PMID: 32155442)
J Neurophysiol. 2016 Jan 1;115(1):19-38. (PMID: 26510756)
Clin Neurophysiol. 2004 Nov;115(11):2431-41. (PMID: 15465430)
J Neurophysiol. 2012 Jan;107(1):364-83. (PMID: 21994263)
Acta Neurochir (Wien). 2011 Aug;153(8):1579-85; discussion 1585. (PMID: 21553318)
Lancet. 1995 Jan 14;345(8942):91-5. (PMID: 7815888)
Nat Rev Neurol. 2017 Sep;13(9):548-554. (PMID: 28752857)
Neuroreport. 2004 May 19;15(7):1137-40. (PMID: 15129161)
معلومات مُعتمدة: R01 NS113893 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: Deep brain stimulation; Essential tremor; Evoked potential; Phase-amplitude coupling
تواريخ الأحداث: Date Created: 20240118 Date Completed: 20240216 Latest Revision: 20240307
رمز التحديث: 20240307
مُعرف محوري في PubMed: PMC10903089
DOI: 10.1016/j.neurot.2023.10.005
PMID: 38237402
قاعدة البيانات: MEDLINE
كن أول من يترك تعليقا!
يجب تسجيل دخولك أولا