دورية أكاديمية
Mitochondrial impairment related to the immunotoxicity of the herbicides clomazone, glyphosate and sulfentrazone in THP-1 cells.
| العنوان: | Mitochondrial impairment related to the immunotoxicity of the herbicides clomazone, glyphosate and sulfentrazone in THP-1 cells. |
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| المؤلفون: | Cestonaro LV; Laboratório de Toxicologia, Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Rua São Luis 150, 3º andar, Santana, 90620-170, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil., da Silva ACG; Laboratório de Ensino e Pesquisa em Toxicologia In Vitro (Tox In), Alameda Flamboyant, Quadra K, Edifício LIFE, Parque Tecnológico Samambaia, Rodovia R2, n. 3.061, Campus Samambaia - Universidade Federal de Goiás, 74690-631, Goiânia, GO, Brazil., Garcia SC; Laboratório de Toxicologia, Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Rua São Luis 150, 3º andar, Santana, 90620-170, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil., Valadares MC; Laboratório de Ensino e Pesquisa em Toxicologia In Vitro (Tox In), Alameda Flamboyant, Quadra K, Edifício LIFE, Parque Tecnológico Samambaia, Rodovia R2, n. 3.061, Campus Samambaia - Universidade Federal de Goiás, 74690-631, Goiânia, GO, Brazil., Arbo MD; Laboratório de Toxicologia, Departamento de Análises, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Rua São Luis 150, 3º andar, Santana, 90620-170, Porto Alegre, RS, Brazil.; Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul - UFRGS, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil. |
| المصدر: | Toxicology research [Toxicol Res (Camb)] 2024 Jan 16; Vol. 13 (1), pp. tfae005. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101587950 Publication Model: eCollection Cited Medium: Print ISSN: 2045-452X (Print) Linking ISSN: 2045452X NLM ISO Abbreviation: Toxicol Res (Camb) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Cambridge : RSC Publishing |
| مستخلص: | Background: Pesticides are indispensable for the cultivation of crops, especially those of economic importance, such as soybeans. Data on the annual use of herbicides in crops show that they correspond to 50%, making it the most used in agriculture. Aim: Therefore, the aim of this study was to evaluate the toxicity of the three commercial herbicides (clomazone, glyphosate, and sulfentrazone) in THP-1 cells. Methods: Cells were incubated with 0-5,000 mg/L of the herbicides for 24 h at 37 °C for cytotoxicity evaluation. Additionally, a few toxicological pathways such as reactive species generation, mitochondrial impairment, and interleukin profile, which have been previously involved in the toxicity of pesticides, were also evaluated. Results: A potential immunotoxic effect of the herbicides on THP-1 cells was observed, especially glyphosate, as it is a powerful agent of cellular immunotoxicity. It was also possible to verify an increase in oxidative stress and IL-8 levels and mitochondrial dysfunction. Conclusion: All herbicides showed cytotoxic effects in THP-1 monocytes, which were related to mitochondrial impairment. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
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| فهرسة مساهمة: | Keywords: IL-8; THP-1 cell line; free radicals; herbicides; immune system; mitochondria |
| تواريخ الأحداث: | Date Created: 20240119 Latest Revision: 20240121 |
| رمز التحديث: | 20240121 |
| مُعرف محوري في PubMed: | PMC10793723 |
| DOI: | 10.1093/toxres/tfae005 |
| PMID: | 38239269 |
| قاعدة البيانات: | MEDLINE |
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