دورية أكاديمية
Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome.
| العنوان: | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome. |
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| المؤلفون: | Miranda Furtado CL; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.; Experimental Biology Center, Graduate Program in Medical Sciences, University of Fortaleza, Fortaleza, Ceará, Brazil.; Drug Research and Development Center, Postgraduate Program in Translational Medicine, Federal University of Ceará, Fortaleza, Brazil., Hansen M; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA., Kogure GS; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Ribeiro VB; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Taylor N; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA., Racy Soares M; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Ferriani RA; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil., Aston KI; Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Jenkins T; Department of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.; Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA., Dos Reis RM; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil. |
| المصدر: | Epigenetics [Epigenetics] 2024 Dec; Vol. 19 (1), pp. 2305082. Date of Electronic Publication: 2024 Jan 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265293 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2308 (Electronic) Linking ISSN: 15592294 NLM ISO Abbreviation: Epigenetics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, Tex. : Landes Bioscience, c2006- |
| مواضيع طبية MeSH: | DNA Methylation* , Polycystic Ovary Syndrome*/genetics , Polycystic Ovary Syndrome*/therapy, Animals ; Female ; Humans ; Health Promotion ; Quality of Life ; DNA ; Mammals |
| مستخلص: | Physical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes. |
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| فهرسة مساهمة: | Keywords: DNA methylation; Polycystic ovary syndrome; aerobic training; physical activity; resistance training |
| المشرفين على المادة: | 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20240121 Date Completed: 20240123 Latest Revision: 20240124 |
| رمز التحديث: | 20240124 |
| مُعرف محوري في PubMed: | PMC10802204 |
| DOI: | 10.1080/15592294.2024.2305082 |
| PMID: | 38245873 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1559-2308 |
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| DOI: | 10.1080/15592294.2024.2305082 |