دورية أكاديمية
أعرض في EDS

Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.

التفاصيل البيبلوغرافية
العنوان: Deficiency in SPOP-mediated ubiquitination and degradation of TIAM1 promotes gastric cancer progression.
المؤلفون: Liu F; Department of Emergency, First Hospital of Jilin University, Changchun, China., Zhang T; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China., Sun X; Department of Emergency, First Hospital of Jilin University, Changchun, China., Liu Z; Department of Emergency, First Hospital of Jilin University, Changchun, China., Xu W; Department of The Clinical Laboratory, First Hospital of Jilin University, Changchun, China. Electronic address: xu_w@jlu.edu.cn., Dai X; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China. Electronic address: daixiangpeng@jlu.edu.cn., Zhang X; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China; National-Local Joint Engineering Laboratory of Animal Models for Human Disease, First Hospital of Jilin University, Changchun, China. Electronic address: xiaolingzhang@jlu.edu.cn.
المصدر: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Mar; Vol. 1870 (3), pp. 167032. Date of Electronic Publication: 2024 Jan 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-260X (Electronic) Linking ISSN: 09254439 NLM ISO Abbreviation: Biochim Biophys Acta Mol Basis Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier
مواضيع طبية MeSH: Stomach Neoplasms*/genetics , Prostatic Neoplasms*/pathology, Male ; Humans ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/genetics ; T-Lymphoma Invasion and Metastasis-inducing Protein 1/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Ubiquitination
مستخلص: It was well known that SPOP is highly mutated in various cancers especially the prostate cancer and SPOP mutation dramatically impaired its tumor suppressive function. However, the detailed role and underlying mechanisms of SPOP in regulating the growth of gastric cancer is not fully studied. Here, we found that Cullin3 SPOP promoted the ubiquitination and degradation of TIAM1 protein in gastric cancer setting. Gastric cancer and prostate cancer derived SPOP mutation failed to suppress the proliferation, migration and invasion of gastric cancer cells partially due to the elevated level of TIAM1 protein. Notably, SPOP protein were negatively associated with TIAM1 protein in human gastric cancer tissue specimens. In conclusion, our results elucidate a molecular mechanism by which SPOP regulates the stability of TIAM1, and further demonstrate that SPOP inhibits the progression of gastric cancer by promoting the ubiquitination and degradation of TIAM1 protein.
Competing Interests: Declaration of competing interest All authors declare no conflict of interest.
(Copyright © 2024. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Degradation; Gastric cancer; SPOP; TIAM1; Ubiquitination
المشرفين على المادة: 0 (Repressor Proteins)
0 (T-Lymphoma Invasion and Metastasis-inducing Protein 1)
0 (Nuclear Proteins)
0 (SPOP protein, human)
0 (TIAM1 protein, human)
تواريخ الأحداث: Date Created: 20240121 Date Completed: 20240220 Latest Revision: 20240227
رمز التحديث: 20240227
DOI: 10.1016/j.bbadis.2024.167032
PMID: 38246227
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-260X
DOI:10.1016/j.bbadis.2024.167032