دورية أكاديمية
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
العنوان: | Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats. |
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المؤلفون: | Aurich S; Institute of Hygiene and Infectious Diseases of Animals, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany., Wolf SA; Genome Competence Centre, Robert Koch Institute, 13353 Berlin, Germany., Prenger-Berninghoff E; Institute of Hygiene and Infectious Diseases of Animals, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany., Thrukonda L; Genome Competence Centre, Robert Koch Institute, 13353 Berlin, Germany., Semmler T; Genome Competence Centre, Robert Koch Institute, 13353 Berlin, Germany., Ewers C; Institute of Hygiene and Infectious Diseases of Animals, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany. |
المصدر: | Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Dec 30; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 30. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, 2012- |
مستخلص: | Extraintestinal pathogenic Escherichia coli (ExPEC) account for over 80% and 60% of bacterial urinary tract infections (UTIs) in humans and animals, respectively. As shared uropathogenic E. coli (UPEC) strains have been previously reported among humans and pets, our study aimed to characterize E. coli lineages among UTI isolates from dogs and cats and to assess their overlaps with human UPEC lineages. We analysed 315 non-duplicate E. coli isolates from the UT of dogs (198) and cats (117) collected in central Germany in 2019 and 2020 utilizing whole genome sequencing and in silico methods. Phylogroup B2 (77.8%), dog-associated sequence type (ST) 372 (18.1%), and human-associated ST73 (16.6%), were predominant. Other STs included ST12 (8.6%), ST141 (5.1%), ST127 (4.8%), and ST131 (3.5%). Among these, 58.4% were assigned to the ExPEC group and 51.1% to the UPEC group based on their virulence associated gene (VAG) profile (ExPEC, presence of ≥VAGs: papAH and/or papC , sfa / focG , afaD / draBC , kpsMT II, and iutA; UPEC , additionally cnf1 or hlyD ). Extended-spectrum cephalosporin (ESC) resistance mediated by extended-spectrum β-lactamases (ESBL) and AmpC-β-lactamase was identified in 1.9% of the isolates, along with one carbapenemase-producing isolate and one isolate carrying a mcr gene. Low occurrence of ESC-resistant or multidrug-resistant (MDR) isolates (2.9%) in the two most frequently detected STs implies that E. coli isolated from UTIs of companion animals are to a lesser extent associated with resistance, but possess virulence-associated genes enabling efficient UT colonization and carriage. Detection of human-related pandemic lineages suggests interspecies transmission and underscores the importance of monitoring companion animals. |
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فهرسة مساهمة: | Keywords: ExPEC; ST372; ST73; UPEC; antimicrobial resistance genes; cat; dog; phylogroup B2 |
تواريخ الأحداث: | Date Created: 20240122 Latest Revision: 20240128 |
رمز التحديث: | 20240128 |
مُعرف محوري في PubMed: | PMC10812829 |
DOI: | 10.3390/antibiotics13010038 |
PMID: | 38247597 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2079-6382 |
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DOI: | 10.3390/antibiotics13010038 |