دورية أكاديمية
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Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations.

التفاصيل البيبلوغرافية
العنوان: Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations.
المؤلفون: de Alba-Gonzalez M; National Centre for Environmental Health, Instituto de Salud Carlos III, 28220 Madrid, Spain., González-Caballero MC; National Centre for Environmental Health, Instituto de Salud Carlos III, 28220 Madrid, Spain., Tarazona JV; National Centre for Environmental Health, Instituto de Salud Carlos III, 28220 Madrid, Spain.
المصدر: Toxics [Toxics] 2023 Dec 28; Vol. 12 (1). Date of Electronic Publication: 2023 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101639637 Publication Model: Electronic Cited Medium: Internet ISSN: 2305-6304 (Electronic) Linking ISSN: 23056304 NLM ISO Abbreviation: Toxics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: The use of pyrethroids is very broad and shows increasing trends. Human biomonitoring studies represent the best approach for realistic risk estimations, but their interpretation requires a tiered approach. A previous HBM4EU study indicated levels in European children groups just around the threshold for concern, requiring further refinement. The main difficulty is that several pyrethroids with different toxicity potencies generate the same urinary metabolites. As diet is the main pyrethroid source for the general population, EU food monitoring data reported by EFSA have been used to estimate the relative contribution of each pyrethroid. The main contributors were cypermethrin for DCCA and 3-PBA and lambda-cyhalothrin for CFMP. Urinary levels predicted from food concentration according to the EFSA diets were mostly within the range of measured levels, except 3-PBA and CFMP levels in children, both below measured levels. The predicted lower levels for 3-PBA can be explained by the very low Fue value, initially proposed as conservative, but that seems to be unrealistic. The discrepancies for CFMP are mostly for the highest percentiles and require further assessments. The refined assessments included the revision of the previously proposed human biomonitoring guidance values for the general population, HBM-GV Gen Pop, following recent toxicological reevaluations, and the estimation of hazard quotients (HQs) for each individual pyrethroid and for the combined exposure to all pyrethroids. All HQs were below 1, indicating no immediate concern, but attention is required, particularly for children, with HQs in the range of 0.2-0.3 for the highly exposed group. The application of probabilistic methods offers assessments at the population level, addressing the variability in exposure and risk and providing relevant information for Public Health impact assessments and risk management prioritization.
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معلومات مُعتمدة: No 101057014. Partnership for the Risk Assessment of Chemicals (PARC)
فهرسة مساهمة: Keywords: 3PBA; CFMP; CLF3CA; DBCA; DCCA; F3PBA; HBM4EU; pesticide risk; pyrethroids; urinary levels
تواريخ الأحداث: Date Created: 20240122 Latest Revision: 20240129
رمز التحديث: 20240129
مُعرف محوري في PubMed: PMC10819063
DOI: 10.3390/toxics12010024
PMID: 38250980
قاعدة البيانات: MEDLINE
الوصف
تدمد:2305-6304
DOI:10.3390/toxics12010024