دورية أكاديمية

Central Nervous System Complications of HIV in Children.

التفاصيل البيبلوغرافية
العنوان: Central Nervous System Complications of HIV in Children.
المؤلفون: Huff HV; National Institutes of Health, National Institute of Neurological Disorders and Stroke, Building 10, 10 Center Drive, Bethesda, MD, 20892, USA., Sportiello K; Department of Neurology, Division of Child Neurology, University of Rochester Medical Center, 160 Elmwood Ave, Rochester, NY, 14618, USA., Bearden DR; Department of Educational Psychology, University of Zambia, Independence Ave, Lusaka, Zambia. david_bearden@urmc.rochester.edu.; Department of Neurology, Division of Child Neurology, University of Rochester Medical Center, 160 Elmwood Ave, Rochester, NY, 14618, USA. david_bearden@urmc.rochester.edu.
المصدر: Current HIV/AIDS reports [Curr HIV/AIDS Rep] 2024 Apr; Vol. 21 (2), pp. 40-51. Date of Electronic Publication: 2024 Jan 22.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Current Science Country of Publication: United States NLM ID: 101235661 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-3576 (Electronic) Linking ISSN: 15483568 NLM ISO Abbreviation: Curr HIV/AIDS Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Philadelphia, PA : Current Science
مواضيع طبية MeSH: HIV Infections*/complications , HIV Infections*/drug therapy , AIDS Dementia Complex* , AIDS-Related Opportunistic Infections*/complications, Child ; Humans ; Central Nervous System
References: Buch S, Chivero ET, Hoare J, Jumare J, Nakasujja N, Mudenda V, et al. Proceedings from the NIMH symposium on “NeuroAIDS in Africa: neurological and neuropsychiatric complications of HIV.” J Neurovirol. 2016;22(5):699–702. https://doi.org/10.1007/s13365-016-0467-y . (PMID: 10.1007/s13365-016-0467-y274731965055435)
Mpango RS, Rukundo GZ, Muyingo SK, Gadow KD, Patel V, Kinyanda E. Prevalence, correlates for early neurological disorders and association with functioning among children and adolescents with HIV/AIDS in Uganda. BMC Psychiatry. 2019;19(1):34. https://doi.org/10.1186/s12888-019-2023-9 . (PMID: 10.1186/s12888-019-2023-9306653826341558)
Johnson TP, Patel K, Johnson KR, Maric D, Calabresi PA, Hasbun R, et al. Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Proc Natl Acad Sci U S A. 2013;110(33):13588–93. https://doi.org/10.1073/pnas.1308673110 . (PMID: 10.1073/pnas.1308673110238982083746932)
Yang B, Akhter S, Chaudhuri A, Kanmogne GD. HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. Microvasc Res. 2009;77(2):212–9. https://doi.org/10.1016/j.mvr.2008.11.003 . (PMID: 10.1016/j.mvr.2008.11.00319103208)
Dhaka G, Sherwal BL, Saxena S, Rai Y, Chandra J. Current trends in opportunistic infections in children living with HIV/AIDS in a tertiary care hospital in Northern India. Indian J Sex Transm Dis AIDS. 2017;38(2):142–6. https://doi.org/10.4103/2589-0557.216992 . (PMID: 10.4103/2589-0557.216992301482676085927)
Shafiq M, Mathad JS, Naik S, Alexander M, Yadana S, Araújo-Pereira M, et al. Association of maternal inflammation during pregnancy with birth outcomes and infant growth among women with or without HIV in India. JAMA Netw Open. 2021;4(12):e2140584. https://doi.org/10.1001/jamanetworkopen.2021.40584 . (PMID: 10.1001/jamanetworkopen.2021.40584349359188696571)
Vyas P, Mathad JS, Leu CS, Naik S, Alexander M, Araújo-Pereira M, et al. Impact of HIV status on systemic inflammation during pregnancy. AIDS. 2021;35(14):2259–68. https://doi.org/10.1097/qad.0000000000003016 . (PMID: 10.1097/qad.000000000000301634261096)
Robertson KR, Su Z, Margolis DM, Krambrink A, Havlir DV, Evans S, et al. Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort. Neurology. 2010;74(16):1260–6. https://doi.org/10.1212/WNL.0b013e3181d9ed09 . (PMID: 10.1212/WNL.0b013e3181d9ed09202373082860482)
Janssen RS, Nwanyanwu OC, Selik RM, Stehr-Green JK. Epidemiology of human immunodeficiency virus encephalopathy in the United States. Neurology. 1992;42(8):1472–6. https://doi.org/10.1212/wnl.42.8.1472 . (PMID: 10.1212/wnl.42.8.14721641138)
Saylor D, Nakigozi G, Nakasujja N, Robertson K, Gray RH, Wawer MJ, et al. Peripheral neuropathy in HIV-infected and uninfected patients in Rakai, Uganda. Neurology. 2017;89(5):485–91. https://doi.org/10.1212/wnl.0000000000004136 . (PMID: 10.1212/wnl.0000000000004136286795965539731)
Benjamin-Damons NA. An investigation of HIV sensory neuropathy in children living with HIV. Johannesburg: University of the Witwatersrand; 2019.
Mekonnen GB, Birhane BM, Engdaw MT, Kindie W, Ayele AD, Wondim A. Predictors of a high incidence of opportunistic infections among HIV-infected children receiving antiretroviral therapy at Amhara regional state comprehensive specialized hospitals, Ethiopia: a multicenter institution-based retrospective follow-up study. Front Pediatr. 2023;11:1107321. https://doi.org/10.3389/fped.2023.1107321 . (PMID: 10.3389/fped.2023.11073213720522110185808)
Melkamu MW, Gebeyehu MT, Afenigus AD, Hibstie YT, Temesgen B, Petrucka P, et al. Incidence of common opportunistic infections among HIV-infected children on ART at Debre Markos referral hospital, Northwest Ethiopia: a retrospective cohort study. BMC Infect Dis. 2020;20(1):50. https://doi.org/10.1186/s12879-020-4772-y . (PMID: 10.1186/s12879-020-4772-y319483936966876)
Candiani TM, Pinto J, Cardoso CA, Carvalho IR, Dias AC, Carneiro M, et al. Impact of highly active antiretroviral therapy (HAART) on the incidence of opportunistic infections, hospitalizations and mortality among children and adolescents living with HIV/AIDS in Belo Horizonte, Minas Gerais State, Brazil. Cad Saude Publica. 2007;23(Suppl 3):S414–23. https://doi.org/10.1590/s0102-311x2007001500009 . (PMID: 10.1590/s0102-311x200700150000917992347)
Vreeman RC, McCoy BM, Lee S. Mental health challenges among adolescents living with HIV. J Int AIDS Soc. 2017;20(Suppl 3):21497. https://doi.org/10.7448/ias.20.4.21497 . (PMID: 10.7448/ias.20.4.21497285300455577712)
Patil G, Mbewe EG, Kabundula PP, Smith H, Mwanza-Kabaghe S, Buda A, et al. Longitudinal cognitive outcomes in children with HIV in Zambia: 2-year outcomes from the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study. J Acquir Immune Defic Syndr. 2022;91(2):217–25. https://doi.org/10.1097/qai.0000000000003052 . (PMID: 10.1097/qai.0000000000003052360944899480865)
Mitchell W. Neurological and developmental effects of HIV and AIDS in children and adolescents. Ment Retard Dev Disabil Res Rev. 2001;7(3):211–6. https://doi.org/10.1002/mrdd.1029 . (PMID: 10.1002/mrdd.102911553937)
Cooper ER, Hanson C, Diaz C, Mendez H, Abboud R, Nugent R, et al. Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. Women and Infants Transmission Study Group. J Pediatr. 1998;132(5):808–12. https://doi.org/10.1016/s0022-3476(98)70308-7 . (PMID: 10.1016/s0022-3476(98)70308-79602190)
Walker SY, Pierre RB, Christie CD, Chang SM. Neurocognitive function in HIV-positive children in a developing country. Int J Infect Dis. 2013;17(10):e862–7. https://doi.org/10.1016/j.ijid.2013.02.014 . (PMID: 10.1016/j.ijid.2013.02.014235623575454494)
Koekkoek S, de Sonneville LM, Wolfs TF, Licht R, Geelen SP. Neurocognitive function profile in HIV-infected school-age children. Eur J Paediatr Neurol. 2008;12(4):290–7. https://doi.org/10.1016/j.ejpn.2007.09.002 . (PMID: 10.1016/j.ejpn.2007.09.00217950012)
van Opstal SEM, Dogterom EJ, Wagener MN, Aarsen FK, Miedema HS, Roelofs P, et al. Neuropsychological and psychosocial functioning of children with perinatal HIV-infection in the Netherlands. Viruses. 2021;13(10):1947. https://doi.org/10.3390/v13101947 .
Gm A, Assefa G. Clinical and neuroimaging profile of HIV-1 encephalopathy in infancy and childhood in a sub-Saharan African country. Ethiop Med J. 2012;50(4):337–47.
Donald KA, Walker KG, Kilborn T, Carrara H, Langerak NG, Eley B, et al. HIV encephalopathy: pediatric case series description and insights from the clinic coalface. AIDS Res Ther. 2015;12(1):2. https://doi.org/10.1186/s12981-014-0042-7 . (PMID: 10.1186/s12981-014-0042-7255988354297380)
Epstein LG, Sharer LR, Oleske JM, Connor EM, Goudsmit J, Bagdon L, et al. Neurologic manifestations of human immunodeficiency virus infection in children. Pediatrics. 1986;78(4):678–87. (PMID: 10.1542/peds.78.4.6782429248)
Chiriboga CA, Fleishman S, Champion S, Gaye-Robinson L, Abrams EJ. Incidence and prevalence of HIV encephalopathy in children with HIV infection receiving highly active anti-retroviral therapy (HAART). J Pediatr. 2005;146(3):402–7. https://doi.org/10.1016/j.jpeds.2004.10.021 . (PMID: 10.1016/j.jpeds.2004.10.02115756229)
Innes S, Laughton B, van Toorn R, Otwombe K, Liberty A, Dobbels E, et al. Recovery of HIV encephalopathy in perinatally infected children on antiretroviral therapy. Dev Med Child Neurol. 2020;62(11):1309–16. https://doi.org/10.1111/dmcn.14639 . (PMID: 10.1111/dmcn.1463932779195)
Mbewe EG, Kabundula PP, Mwanza-Kabaghe S, Buda A, Adams HR, Schneider C, et al. Socioeconomic status and cognitive function in children with HIV: evidence from the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study. J Acquir Immune Defic Syndr. 2022;89(1):56–63. https://doi.org/10.1097/qai.0000000000002825 . (PMID: 10.1097/qai.0000000000002825348784358794014)
Brew BJ, Dunbar N, Pemberton L, Kaldor J. Predictive markers of AIDS dementia complex: CD4 cell count and cerebrospinal fluid concentrations of beta 2-microglobulin and neopterin. J Infect Dis. 1996;174(2):294–8. https://doi.org/10.1093/infdis/174.2.294 . (PMID: 10.1093/infdis/174.2.2948699058)
Yilmaz A, Price RW, Spudich S, Fuchs D, Hagberg L, Gisslén M. Persistent intrathecal immune activation in HIV-1-infected individuals on antiretroviral therapy. J Acquir Immune Defic Syndr. 2008;47(2):168–73. https://doi.org/10.1097/QAI.0b013e31815ace97 . (PMID: 10.1097/QAI.0b013e31815ace97179717112628632)
Desplats P, Dumaop W, Smith D, Adame A, Everall I, Letendre S, et al. Molecular and pathologic insights from latent HIV-1 infection in the human brain. Neurology. 2013;80(15):1415–23. https://doi.org/10.1212/WNL.0b013e31828c2e9e . (PMID: 10.1212/WNL.0b013e31828c2e9e234868773662272)
Molinaro M, Adams HR, Mwanza-Kabaghe S, Mbewe EG, Kabundula PP, Mweemba M, et al. Evaluating the relationship between depression and cognitive function among children and adolescents with HIV in Zambia. AIDS Behav. 2021;25(9):2669–79. https://doi.org/10.1007/s10461-021-03193-0 . (PMID: 10.1007/s10461-021-03193-0336302008456506)
Buda A, Dean O, Adams HR, Mwanza-Kabaghe S, Potchen MJ, Mbewe EG, et al. Neighborhood-based socioeconomic determinants of cognitive impairment in Zambian children with HIV: a quantitative geographic information systems approach. J Pediatric Infect Dis Soc. 2021;10(12):1071–9. https://doi.org/10.1093/jpids/piab076 . (PMID: 10.1093/jpids/piab076344377028719623)
Kandawasvika GQ, Kuona P, Chandiwana P, Masanganise M, Gumbo FZ, Mapingure MP, et al. The burden and predictors of cognitive impairment among 6- to 8-year-old children infected and uninfected with HIV from Harare, Zimbabwe: a cross-sectional study. Child Neuropsychol. 2015;21(1):106–20. https://doi.org/10.1080/09297049.2013.876493 . (PMID: 10.1080/09297049.2013.87649324409987)
WHO. Updated recommendations on HIV prevention, infant diagnosis, antiretroviral initiation and monitoring. World Health Organization; 2021. p. 84.  https://www.who.int/publications/i/item/9789240022232 .
Ackermann C, Andronikou S, Laughton B, Kidd M, Dobbels E, Innes S, et al. White matter signal abnormalities in children with suspected HIV-related neurologic disease on early combination antiretroviral therapy. Pediatr Infect Dis J. 2014;33(8):e207–12. https://doi.org/10.1097/inf.0000000000000288 . (PMID: 10.1097/inf.0000000000000288245950474153800)
Dahl V, Peterson J, Fuchs D, Gisslen M, Palmer S, Price RW. Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation. AIDS. 2014;28(15):2251–8. https://doi.org/10.1097/qad.0000000000000400 . (PMID: 10.1097/qad.000000000000040025022595)
Gama L, Abreu CM, Shirk EN, Price SL, Li M, Laird GM, et al. Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaques. AIDS. 2017;31(1):5–14. https://doi.org/10.1097/qad.0000000000001267 . (PMID: 10.1097/qad.000000000000126727898590)
Van den Hof M, Blokhuis C, Cohen S, Scherpbier HJ, Wit F, Pistorius MCM, et al. CNS penetration of ART in HIV-infected children. J Antimicrob Chemother. 2018;73(2):484–9. https://doi.org/10.1093/jac/dkx396 . (PMID: 10.1093/jac/dkx39629126299)
Burdo TH, Lentz MR, Autissier P, Krishnan A, Halpern E, Letendre S, et al. Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J Infect Dis. 2011;204(1):154–63. https://doi.org/10.1093/infdis/jir214 . (PMID: 10.1093/infdis/jir214216286703105035)
Kapetanovic S, Griner R, Zeldow B, Nichols S, Leister E, Gelbard HA, et al. Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis. AIDS. 2014;28(3):355–64. https://doi.org/10.1097/qad.0000000000000072 . (PMID: 10.1097/qad.000000000000007224670521)
Burdo TH, Weiffenbach A, Woods SP, Letendre S, Ellis RJ, Williams KC. Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection. AIDS. 2013;27(9):1387–95. https://doi.org/10.1097/QAD.0b013e32836010bd . (PMID: 10.1097/QAD.0b013e32836010bd23435298)
Robertson K, Liner J, Meeker RB. Antiretroviral neurotoxicity. J Neurovirol. 2012;18(5):388–99. https://doi.org/10.1007/s13365-012-0120-3 . (PMID: 10.1007/s13365-012-0120-3228112643581315)
Thakur KT, Boubour A, Saylor D, Das M, Bearden DR, Birbeck GL. Global HIV neurology: a comprehensive review. AIDS. 2019;33(2):163–84. https://doi.org/10.1097/qad.0000000000001796 . (PMID: 10.1097/qad.000000000000179629547440)
Nichols SL. Central nervous system impact of perinatally acquired HIV in adolescents and adults: an update. Curr HIV/AIDS Rep. 2022;19(1):121–32. https://doi.org/10.1007/s11904-021-00598-3 . (PMID: 10.1007/s11904-021-00598-3351078098904346)
Hof MVd, Haar AMt, Caan MWA, Spijker R, Lee JHvd, Pajkrt D. Brain structure of perinatally HIV-infected patients on long-term treatment. A systematic review. Neurol Clin Pract. 2019;9(5):433–42. https://doi.org/10.1212/cpj.0000000000000637 .
Donald KA, Hoare J, Eley B, Wilmshurst JM. Neurologic complications of pediatric human immunodeficiency virus: implications for clinical practice and management challenges in the African setting. Semin Pediatr Neurol. 2014;21(1):3–11. https://doi.org/10.1016/j.spen.2014.01.004 . (PMID: 10.1016/j.spen.2014.01.00424655398)
Blake Caldwell M, Oxtoby MJ, Simonds JR, Lindegren ML, Rogers MF. 1994 revised classification system for human immunodeficiency virus infection in children less than 13 years of age. 1994;43(RR-12):1–10.  https://www.cdc.gov/mmwr/preview/mmwrhtml/00032890.htm . Accessed 2023.
Carroll A, Brew B. HIV-associated neurocognitive disorders: recent advances in pathogenesis, biomarkers, and treatment. F1000Res. 2017;6:312. https://doi.org/10.12688/f1000research.10651.1 . (PMID: 10.12688/f1000research.10651.1284136255365228)
Sherr L, Croome N, Castaneda KP, Bradshaw K, Romero RH. Developmental challenges in HIV infected children – an updated systematic review. Child Youth Serv Rev. 2014;45:74–89. https://doi.org/10.1016/j.childyouth.2014.03.040 . (PMID: 10.1016/j.childyouth.2014.03.040)
Stadtler H, Shaw G, Neigh GN. Mini-review: elucidating the psychological, physical, and sex-based interactions between HIV infection and stress. Neurosci Lett. 2021;747:135698. https://doi.org/10.1016/j.neulet.2021.135698 . (PMID: 10.1016/j.neulet.2021.135698335400579258904)
Phillips N, Amos T, Kuo C, Hoare J, Ipser J, Thomas KG, et al. HIV-associated cognitive impairment in perinatally infected children: a meta-analysis. Pediatrics. 2016;138(5). https://doi.org/10.1542/peds.2016-0893 .
Nichols SL, Chernoff MC, Malee KM, Sirois PA, Woods SP, Williams PL, et al. Executive functioning in children and adolescents with perinatal HIV infection and perinatal HIV exposure. J Pediatric Infect Dis Soc. 2016;5(suppl 1):S15-s23. https://doi.org/10.1093/jpids/piw049 . (PMID: 10.1093/jpids/piw049278566725181544)
Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69(18):1789–99. https://doi.org/10.1212/01.WNL.0000287431.88658.8b . (PMID: 10.1212/01.WNL.0000287431.88658.8b17914061)
Hoare J, Phillips N, Joska JA, Paul R, Donald KA, Stein DJ, et al. Applying the HIV-associated neurocognitive disorder diagnostic criteria to HIV-infected youth. Neurology. 2016;87(1):86–93. https://doi.org/10.1212/wnl.0000000000002669 . (PMID: 10.1212/wnl.0000000000002669272067204932240)
Bearden DR, Meyer AC. Should the Frascati criteria for HIV-associated neurocognitive disorders be used in children? Neurology. 2016;87(1):17–8. https://doi.org/10.1212/wnl.0000000000002785 . (PMID: 10.1212/wnl.000000000000278527206721)
Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, et al. HIV-associated neurocognitive disorder–pathogenesis and prospects for treatment. Nat Rev Neurol. 2016;12(4):234–48. https://doi.org/10.1038/nrneurol.2016.27 . (PMID: 10.1038/nrneurol.2016.27269656744937456)
Zayyad Z, Spudich S. Neuropathogenesis of HIV: from initial neuroinvasion to HIV-associated neurocognitive disorder (HAND). Curr HIV/AIDS Rep. 2015;12(1):16–24. https://doi.org/10.1007/s11904-014-0255-3 . (PMID: 10.1007/s11904-014-0255-3256042374741099)
Dean O, Buda A, Adams HR, Mwanza-Kabaghe S, Potchen MJ, Mbewe EG, et al. Brain magnetic resonance imaging findings associated with cognitive impairment in children and adolescents with human immunodeficiency virus in Zambia. Pediatr Neurol. 2020;102:28–35. https://doi.org/10.1016/j.pediatrneurol.2019.08.014 . (PMID: 10.1016/j.pediatrneurol.2019.08.01431604645)
Schneider CL, Mohajeri-Moghaddam S, Mbewe EG, Kabundula PP, Dean O, Buda A, et al. Cerebrovascular disease in children perinatally infected with human immunodeficiency virus in Zambia. Pediatr Neurol. 2020;112:14–21. https://doi.org/10.1016/j.pediatrneurol.2020.08.003 . (PMID: 10.1016/j.pediatrneurol.2020.08.003328714117554106)
Galgani S, Balestra P, Narciso P, Tozzi V, Sette P, Pau F, et al. Nimodipine plus zidovudine versus zidovudine alone in the treatment of HIV-1-associated cognitive deficits. AIDS. 1997;11(12):1520–1. (PMID: 9342076)
Safety and tolerability of the antioxidant OPC-14117 in HIV-associated cognitive impairment. The Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Neurology. 1997;49(1):142–6. https://doi.org/10.1212/wnl.49.1.142 .
Heseltine PN, Goodkin K, Atkinson JH, Vitiello B, Rochon J, Heaton RK, et al. Randomized double-blind placebo-controlled trial of peptide T for HIV-associated cognitive impairment. Arch Neurol. 1998;55(1):41–51. https://doi.org/10.1001/archneur.55.1.41 . (PMID: 10.1001/archneur.55.1.419443710)
A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment. Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders. Neurology. 1998;50(3):645–51. https://doi.org/10.1212/wnl.50.3.645 .
Schifitto G, Sacktor N, Marder K, McDermott MP, McArthur JC, Kieburtz K, et al. Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. Neurology. 1999;53(2):391–6. https://doi.org/10.1212/wnl.53.2.391 . (PMID: 10.1212/wnl.53.2.39110430432)
Sacktor N, Schifitto G, McDermott MP, Marder K, McArthur JC, Kieburtz K. Transdermal selegiline in HIV-associated cognitive impairment: pilot, placebo-controlled study. Neurology. 2000;54(1):233–5. https://doi.org/10.1212/wnl.54.1.233 . (PMID: 10.1212/wnl.54.1.23310636157)
Clifford DB, McArthur JC, Schifitto G, Kieburtz K, McDermott MP, Letendre S, et al. A randomized clinical trial of CPI-1189 for HIV-associated cognitive-motor impairment. Neurology. 2002;59(10):1568–73. https://doi.org/10.1212/01.wnl.0000034177.47015.da . (PMID: 10.1212/01.wnl.0000034177.47015.da12451199)
Schifitto G, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, et al. Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. AIDS. 2007;21(14):1877–86. https://doi.org/10.1097/QAD.0b013e32813384e8 . (PMID: 10.1097/QAD.0b013e32813384e817721095)
Schifitto G, Zhang J, Evans SR, Sacktor N, Simpson D, Millar LL, et al. A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment. Neurology. 2007;69(13):1314–21. https://doi.org/10.1212/01.wnl.0000268487.78753.0f . (PMID: 10.1212/01.wnl.0000268487.78753.0f17652642)
Sacktor N, Miyahara S, Deng L, Evans S, Schifitto G, Cohen BA, et al. Minocycline treatment for HIV-associated cognitive impairment: results from a randomized trial. Neurology. 2011;77(12):1135–42. https://doi.org/10.1212/WNL.0b013e31822f0412 . (PMID: 10.1212/WNL.0b013e31822f0412219006363174065)
Sacktor N, Skolasky RL, Moxley R, Wang S, Mielke MM, Munro C, et al. Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. J Neurovirol. 2018;24(1):16–27. https://doi.org/10.1007/s13365-017-0587-z . (PMID: 10.1007/s13365-017-0587-z29063516)
Cole JW, Pinto AN, Hebel JR, Buchholz DW, Earley CJ, Johnson CJ, et al. Acquired immunodeficiency syndrome and the risk of stroke. Stroke. 2004;35(1):51–6. https://doi.org/10.1161/01.Str.0000105393.57853.11 . (PMID: 10.1161/01.Str.0000105393.57853.1114684782)
Wilmshurst JM, Donald KA, Eley B. Update on the key developments of the neurologic complications in children infected with HIV. Curr Opin HIV AIDS. 2014;9(6):533–8. https://doi.org/10.1097/coh.0000000000000101 . (PMID: 10.1097/coh.000000000000010125188807)
Hammond CK, Shapson-Coe A, Govender R, van Toorn R, Ndondo A, Wieselthaler N, et al. Moyamoya syndrome in South African children with HIV-1 infection. J Child Neurol. 2016;31(8):1010–7. https://doi.org/10.1177/0883073816635747 . (PMID: 10.1177/088307381663574726961262)
Levy ML, Levy DM, Manna B: Pediatric Cerebral Aneurysm. StatPearls Publishing; 2023.  https://www.ncbi.nlm.nih.gov/books/NBK537085/ . Accessed 2023.
Patsalides AD, Wood LV, Atac GK, Sandifer E, Butman JA, Patronas NJ. Cerebrovascular disease in HIV-infected pediatric patients: neuroimaging findings. AJR Am J Roentgenol. 2002;179(4):999–1003. https://doi.org/10.2214/ajr.179.4.1790999 . (PMID: 10.2214/ajr.179.4.179099912239054)
Lallemant C, Halembokaka G, Baty G, Ngo-Giang-Huong N, Barin F, Le Coeur S. Impact of HIV/aids on child mortality before the highly active antiretroviral therapy era: a study in Pointe-Noire, Republic of Congo. J Trop Med. 2010;2010. https://doi.org/10.1155/2010/897176 .
Centers for Disease Control and Prevention, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the HHS Panel on Opportunistic Infections in HIV-Exposed and HIV-Infected Children—A Working Group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the prevention and treatment of opportunistic infections in children with and exposed to HIV. 2022.  https://clinicalinfo.hiv.gov/sites/default/files/guidelines/archive/pediatric-oi-2022-09-02.pdf . Accessed 2023.
Ravichandra KR, Praharaj BR, Agarwalla S. Opportunistic infections in HIV infected children and its correlation with CD4 count. Int J Contemp Pediatr. 2017;4(5):1743–7. (PMID: 10.18203/2349-3291.ijcp20173777)
Jones CE, Naidoo S, De Beer C, Esser M, Kampmann B, Hesseling AC. Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants. JAMA. 2011;305(6):576–84. https://doi.org/10.1001/jama.2011.100 . (PMID: 10.1001/jama.2011.10021304083)
WHO. WHO recommendations on the diagnosis of HIV infection in infants and children. World Health Organization; 2010.  https://www.who.int/publications/i/item/9789241599085 .
Boivin MJ, Barlow-Mosha L, Chernoff MC, Laughton B, Zimmer B, Joyce C, et al. Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial. AIDS. 2018;32(2):189–204. https://doi.org/10.1097/qad.0000000000001683 . (PMID: 10.1097/qad.000000000000168329112069)
Benki-Nugent S, Tamasha N, Mueni A, Laboso T, Wamalwa DC, Njuguna I, et al. Early antiretroviral therapy reduces severity but does not eliminate neurodevelopmental compromise in children with HIV. J Acquir Immune Defic Syndr. 2023;93(1):7–14. https://doi.org/10.1097/qai.0000000000003165 . (PMID: 10.1097/qai.000000000000316536693138)
Howland LC, Storm DS, Crawford SL, Ma Y, Gortmaker SL, Oleske JM. Negative life events: risk to health-related quality of life in children and youth with HIV infection. J Assoc Nurses AIDS Care. 2007;18(1):3–11. https://doi.org/10.1016/j.jana.2006.11.008 . (PMID: 10.1016/j.jana.2006.11.00817338981)
Garvie PA, Brummel SS, Allison SM, Malee KM, Mellins CA, Wilkins ML, et al. Roles of medication responsibility, executive and adaptive functioning in adherence for children and adolescents with perinatally acquired HIV. Pediatr Infect Dis J. 2017;36(8):751–7. https://doi.org/10.1097/inf.0000000000001573 . (PMID: 10.1097/inf.0000000000001573287091615512435)
Adams HR, Mwanza-Kabaghe S, Mbewe EG, Kabundula PP, Potchen MJ, Maggirwar S, et al. The HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study: protocol of a research program in pediatric HIV in sub-Saharan Africa. medRxiv. Journal of HIV/AIDS & Infectious Diseases. 2019;5:1–18. https://doi.org/10.1101/19003590 .
WHO, UNAIDS, UNICEF. Progress report 2011: Global HIV/AIDS response. WHO UNAIDS UNICEF; 2011.  https://www.unaids.org/sites/default/files/media_asset/20111130_UA_Report_en_1.pdf .
معلومات مُعتمدة: K23NS117310 National Institute of Neurological Disorders and Stroke of the National Institutes of Health
فهرسة مساهمة: Keywords: Child neurology; Cognitive impairment; HIV; HIV encephalopathy; Opportunistic infections
تواريخ الأحداث: Date Created: 20240122 Date Completed: 20240415 Latest Revision: 20240529
رمز التحديث: 20240529
DOI: 10.1007/s11904-024-00689-x
PMID: 38252368
قاعدة البيانات: MEDLINE
الوصف
تدمد:1548-3576
DOI:10.1007/s11904-024-00689-x