دورية أكاديمية
أعرض في EDS

Venous invasion detectable only by elastic stain shows weak prognostic value in colon cancer.

التفاصيل البيبلوغرافية
العنوان: Venous invasion detectable only by elastic stain shows weak prognostic value in colon cancer.
المؤلفون: Fei LYN; Department of Surgery, Queen's University, Kingston, ON, Canada., Patel SV; Department of Surgery, Queen's University, Kingston, ON, Canada., Popa T; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada., Boudreau L; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada., Caycedo-Marulanda A; Department of Surgery, Queen's University, Kingston, ON, Canada.; Orlando Health Colon and Rectal Institute, Orlando, FL, USA., Grin A; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada., Wang T; Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.
المصدر: Histopathology [Histopathology] 2024 May; Vol. 84 (6), pp. 1038-1046. Date of Electronic Publication: 2024 Jan 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2559 (Electronic) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Blackwell Scientific Publications.
مواضيع طبية MeSH: Colorectal Neoplasms*/pathology , Colonic Neoplasms*/diagnosis , Colonic Neoplasms*/pathology, Humans ; Prognosis ; Coloring Agents ; Neoplasm Staging ; Neoplasm Invasiveness/pathology ; Retrospective Studies
مستخلص: Aims: Large venous invasion (VI) is prognostically significant in colon cancer. The increased use of elastic stains by pathologists results in higher VI detection rates compared to routine stains alone. This study assesses the prognostic value of VI detected by elastic versus routine stains.
Methods and Results: Colon cancers resected between 2014 and 2017 underwent pathology slide review for VI. Cases without VI on routine stain were stained by elastic trichrome and re-examined. Demographic, clinical, pathological and outcome data were gathered by retrospective review. Kaplan-Meier curves with log-rank tests were performed for survival categorised by VI status. Cox regression was performed for multivariate analysis. Of 277 cases, 97 (35%) showed VI by routine stain alone, with an additional 58 (21%) discovered by subsequent elastic stains. Thus, elastic trichrome increased VI detection by 60%. However, only VI detected by routine stain showed worse overall survival (P < 0.001). VI detected by elastic stain only was not prognostically different from cases without VI (P = 0.428). For stage 2 cancers, VI was not prognostically significant regardless of method of detection. For stage 3 cases, only VI detected by routine stain was prognostic for overall survival (P = 0.002) with a hazard ratio of 4.04 by multivariate regression (P = 0.028).
Conclusions: VI detectable only by elastic stains do not show prognostic significance for survival in colon cancer. For pathologists with high baseline VI detections rates on routine stain, reflexive use of elastic stain may be of limited value.
(© 2024 The Authors. Histopathology published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: Queen's University
فهرسة مساهمة: Keywords: colon cancer; elastic trichrome; survival; venous invasion
المشرفين على المادة: 0 (Coloring Agents)
تواريخ الأحداث: Date Created: 20240122 Date Completed: 20240404 Latest Revision: 20240404
رمز التحديث: 20240404
DOI: 10.1111/his.15149
PMID: 38253910
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2559
DOI:10.1111/his.15149