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Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes.

التفاصيل البيبلوغرافية
العنوان: Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes.
المؤلفون: Luo K; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Chen GC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Nutrition and Food Hygiene, MOE Key Laboratory of Geriatric Diseases and Immunology, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China., Zhang Y; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Moon JY; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Xing J; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Peters BA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Usyk M; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Wang Z; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Hu G; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Li J; Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rebholz CM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Wang T; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Isasi CR; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Yu B; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Knight R; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA.; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Burk RD; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. qibin.qi@einsteinmed.edu.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. qibin.qi@einsteinmed.edu.
المصدر: Nature metabolism [Nat Metab] 2024 Jan; Vol. 6 (1), pp. 169-186. Date of Electronic Publication: 2024 Jan 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer Nature, [2019]-
مواضيع طبية MeSH: Lactase*/genetics , Lactase*/metabolism , Diabetes Mellitus, Type 2*/genetics, Male ; Female ; Animals ; Cattle ; Humans ; Milk ; Genotype ; Diet
مستخلص: Cow's milk is frequently included in the human diet, but the relationship between milk intake and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic Community Health Study/Study of Latinos, we show that in both sexes, higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactase LCT gene, single nucleotide polymorphism rs4988235 ) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal that among LNP individuals, higher milk intake is associated with alterations in gut microbiota (for example, enriched Bifidobacterium and reduced Prevotella) and circulating metabolites (for example, increased indolepropionate and reduced branched-chain amino acid metabolites). Many of these metabolites are related to the identified milk-associated bacteria and partially mediate the association between milk intake and T2D in LNP individuals. Our study demonstrates a protective association between milk intake and T2D among LNP individuals and a potential involvement of gut microbiota and blood metabolites in this association.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
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المشرفين على المادة: EC 3.2.1.108 (Lactase)
تواريخ الأحداث: Date Created: 20240122 Date Completed: 20240130 Latest Revision: 20240923
رمز التحديث: 20240923
مُعرف محوري في PubMed: PMC11097298
DOI: 10.1038/s42255-023-00961-1
PMID: 38253929
قاعدة البيانات: MEDLINE
الوصف
تدمد:2522-5812
DOI:10.1038/s42255-023-00961-1