دورية أكاديمية
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Anti-Inflammatory Flavonoids from Agrimonia pilosa Ledeb: Focusing on Activity-Guided Isolation.

التفاصيل البيبلوغرافية
العنوان: Anti-Inflammatory Flavonoids from Agrimonia pilosa Ledeb: Focusing on Activity-Guided Isolation.
المؤلفون: Park M; Department of Horticultural Sciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Ryu D; Department of Horticultural Sciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Cho J; Department of Horticultural Sciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea., Ku KM; Department of Plant Biotechnology, Korea University, Seoul 02841, Republic of Korea., Kang YH; Department of Horticultural Sciences, College of Agriculture & Life Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2024 Jan 05; Vol. 29 (2). Date of Electronic Publication: 2024 Jan 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Flavonoids*/pharmacology , Agrimonia*, Quercetin ; Kaempferols ; Nitric Oxide ; Anti-Inflammatory Agents/pharmacology
مستخلص: To elucidate the anti-inflammatory properties and constituents of Agrimonia pilosa Ledeb. ( A. pilosa ), a comprehensive investigation was conducted employing activity-guided isolation. The anti-inflammatory effects were evaluated through an in vitro nitric oxide (NO) assay on lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. Seven bio-active compounds with anti-inflammatory properties were successfully isolated from the butanol fraction and identified as follows: quercetin-7- O -β-d-rhamnoside ( 1 ), apigenin-7- O -β-d-glucopyranoside ( 2 ), kaempferol-7- O -β-d-glucopyranoside ( 3 ), quercetin ( 4 ), kaempferol ( 5 ), apigenin ( 6 ), and apigenin-7- O -β-d-glucuronide-6″-butylester ( 7 ). All isolated compounds showed strong NO inhibitory activity with IC 50 values ranging from 1.4 to 31 µM. Compound 6 demonstrated the most potent NO inhibition. Compound 7 , a rare flavonoid, was discerned as a novel anti-inflammatory agent, ascertained through its inaugural demonstration of nitric oxide inhibition. Subsequently, a comprehensive structure-activity relationship (SAR) analysis was conducted employing eight flavonoids derived from A. pilosa . The outcomes elucidated that flavones exhibit superior NO inhibitory effects compared to flavonols, and the aglycone form manifests greater potency in NO inhibition than the glycone counterpart. These results highlight A. pilosa as a promising source of effective anti-inflammatory agents and indicate its potential as a health-beneficial dietary supplement and therapeutic material.
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معلومات مُعتمدة: NRF-2015R1D1A3A01020708 National Research Foundation of Korea
فهرسة مساهمة: Keywords: Agrimonia pilosa; anti-inflammatory compounds; bioactivity-guided isolation; nitric oxide inhibitory activity
المشرفين على المادة: 0 (Flavonoids)
9IKM0I5T1E (Quercetin)
0 (Kaempferols)
31C4KY9ESH (Nitric Oxide)
0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20240123 Date Completed: 20240124 Latest Revision: 20240129
رمز التحديث: 20240129
مُعرف محوري في PubMed: PMC10819444
DOI: 10.3390/molecules29020283
PMID: 38257196
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules29020283