دورية أكاديمية
Extracellular vesicles and microvilli in the immune synapse.
| العنوان: | Extracellular vesicles and microvilli in the immune synapse. |
|---|---|
| المؤلفون: | Ruiz-Navarro J; Department of Metabolism and Cell Signaling, Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain., Calvo V; Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Madrid, Spain., Izquierdo M; Department of Metabolism and Cell Signaling, Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. |
| المصدر: | Frontiers in immunology [Front Immunol] 2024 Jan 03; Vol. 14, pp. 1324557. Date of Electronic Publication: 2024 Jan 03 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Extracellular Vesicles*, Microvilli ; Synapses ; Cell Membrane ; Receptors, Antigen, T-Cell |
| مستخلص: | T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a dedicated contact region between different cells that comprises a signaling platform where several cues evoked by TCR and accessory molecules are integrated, ultimately leading to an effective TCR signal transmission that guarantees intercellular message communication. This eventually leads to T lymphocyte activation and the efficient execution of different T lymphocyte effector tasks, including cytotoxicity and subsequent target cell death. Recent evidence demonstrates that the transmission of information between immune cells forming synapses is produced, to a significant extent, by the generation and secretion of distinct extracellular vesicles (EV) from both the effector T lymphocyte and the APC. These EV carry biologically active molecules that transfer cues among immune cells leading to a broad range of biological responses in the recipient cells. Included among these bioactive molecules are regulatory miRNAs, pro-apoptotic molecules implicated in target cell apoptosis, or molecules triggering cell activation. In this study we deal with the different EV classes detected at the IS, placing emphasis on the most recent findings on microvilli/lamellipodium-produced EV. The signals leading to polarized secretion of EV at the synaptic cleft will be discussed, showing that the IS architecture fulfills a fundamental task during this route. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Ruiz-Navarro, Calvo and Izquierdo.) |
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| فهرسة مساهمة: | Keywords: FMNL1β; T lymphocytes; actin cytoskeleton; extracellular vesicles; immune synapse; microvilli; multivesicular bodies; protein kinase C δ |
| المشرفين على المادة: | 0 (Receptors, Antigen, T-Cell) |
| تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240126 Latest Revision: 20240404 |
| رمز التحديث: | 20240405 |
| مُعرف محوري في PubMed: | PMC10806406 |
| DOI: | 10.3389/fimmu.2023.1324557 |
| PMID: | 38268920 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2023.1324557 |