دورية أكاديمية
Antimicrobial stewardship capacity and antibiotic utilisation practices in the Cape Coast Teaching Hospital, Ghana: A point prevalence survey study.
| العنوان: | Antimicrobial stewardship capacity and antibiotic utilisation practices in the Cape Coast Teaching Hospital, Ghana: A point prevalence survey study. |
|---|---|
| المؤلفون: | Agyare E; Clinical Microbiology, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Acolatse JEE; Research and Development Unit, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Dakorah MP; Microbiology Department, Bacteriology Unit, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Akafity G; Research and Development Unit, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Chalker VJ; Clinical Services, National Health Service Blood and Transplant, London, United Kingdom., Spiller OB; Medical Microbiology, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom., Schneider KA; Department of Mathematics, Hochschule Mittweida University of Applied Sciences, Mittweida, Germany., Yevutsey S; National Antimicrobial Resistance Secretariat, Office of Pharmaceutical Services, Ministry of Health, Accra, Ghana., Aidoo NB; Research and Development Unit, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Blankson S; Directorate of Nursing Services, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Mensah-Acheampong F; Directorate of Administrative Services, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Incoom R; Pharmacy Directorate, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana., Kurdi A; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.; Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, Iraq., Godman B; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates.; Department of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa., Ngyedu EK; Directorate of Administrative Services, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana.; Department of Oral and Maxillofacial Surgery, Cape Coast Teaching Hospital, Cape Coast, Central Region, Ghana. |
| المصدر: | PloS one [PLoS One] 2024 Jan 25; Vol. 19 (1), pp. e0297626. Date of Electronic Publication: 2024 Jan 25 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Anti-Bacterial Agents*/therapeutic use , Antimicrobial Stewardship*, Adult ; Humans ; Ghana/epidemiology ; Prevalence ; Surveys and Questionnaires ; Hospitals, Teaching ; Drug Prescriptions |
| مستخلص: | Introduction: Antimicrobial resistance (AMR) is a global threat that necessitates coordinated strategies to improve antibiotic prescribing and reduce AMR. A key activity is ascertaining current prescribing patterns in hospitals to identify targets for quality improvement programmes. Methods: The World Health Organisation point prevalence survey methodology was used to assess antibiotic prescribing in the Cape Coast Teaching Hospital. All core variables identified by the methodology were recorded. Results: A total of 78.8% (82/104) patients were prescribed at least one antibiotic, with the majority from adult surgical wards (52.14%). Significantly longer hospital stays were associated with patients who underwent surgery (p = 0.0423). "Access" antibiotics dominated total prescriptions (63.8%, 132/207) with ceftriaxone, cefuroxime, and ciprofloxacin being the most prescribed "Watch" antibiotics. The most common indications were for medical prophylaxis (59.8%, 49/82) and surgical prophylaxis (46.3%, 38/82). Over one-third of surgical prophylaxis (34.2%, 13/38) indications extended beyond one day. There was moderate documentation of reasons for antibiotic treatment in patient notes (65.9%, 54/82), and targeted therapy after samples were taken for antimicrobial susceptibility testing (41.7%, 10/24). Guideline compliance was low (25%) where available. Conclusions: There was high use of antibiotics within the hospital which needs addressing. Identified quality targets include developing surgical prophylaxis guidelines, reviewing "Watch" antibiotic prescribing, and assessing antibiotic durations for patients on two or more antibiotics. Organizational-level deficiencies were also identified that need addressing to help instigate ASPs. These can be addressed by developing local prescribing protocols and antibiotic stewardship policies in this hospital and wider in Ghana and across Africa. Competing Interests: The authors have declared that no competing interests exist. (Copyright: © 2024 Agyare et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240129 Latest Revision: 20240129 |
| رمز التحديث: | 20240129 |
| مُعرف محوري في PubMed: | PMC10810544 |
| DOI: | 10.1371/journal.pone.0297626 |
| PMID: | 38271388 |
| قاعدة البيانات: | MEDLINE |
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