دورية أكاديمية
Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography.
| العنوان: | Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography. |
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| المؤلفون: | Karki P; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota karki.pragalv@mayo.edu., Murphy MC; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota., Cogswell PM; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota., Senjem ML; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota., Graff-Radford J; Department of Neurology (J.G.-R.), Mayo Clinic College of Medicine, Rochester, Minnesota., Elder BD; Department of Neurologic Surgery (B.D.E., C.S.G., F.B.M.), Mayo Clinic College of Medicine, Rochester, Minnesota., Perry A; Department of Neurosurgery (A.P.), Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel., Graffeo CS; Department of Neurologic Surgery (B.D.E., C.S.G., F.B.M.), Mayo Clinic College of Medicine, Rochester, Minnesota.; Department of Neurosurgery (C.S.G.), University of Oklahoma, Oklahoma City, Oklahoma., Meyer FB; Department of Neurologic Surgery (B.D.E., C.S.G., F.B.M.), Mayo Clinic College of Medicine, Rochester, Minnesota., Jack CR Jr; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota., Ehman RL; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota., Huston J 3rd; From the Department of Radiology (P.K., M.C.M., P.M.C., M.L.S., J.G.-R., C.R.J., R.L.E., J.H.), Mayo Clinic College of Medicine, Rochester, Minnesota. |
| المصدر: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Mar 07; Vol. 45 (3), pp. 328-334. Date of Electronic Publication: 2024 Mar 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oak Brook, IL : American Society of Neuroradiology Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Hydrocephalus, Normal Pressure*/diagnostic imaging , Hydrocephalus, Normal Pressure*/surgery , Elasticity Imaging Techniques* , Hydrocephalus*, Humans ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain/surgery ; Treatment Outcome |
| مستخلص: | Background and Purpose: Normal pressure hydrocephalus is a treatable cause of dementia associated with distinct mechanical property signatures in the brain as measured by MR elastography. In this study, we tested the hypothesis that specific anatomic features of normal pressure hydrocephalus are associated with unique mechanical property alterations. Then, we tested the hypothesis that summary measures of these mechanical signatures can be used to predict clinical outcomes. Materials and Methods: MR elastography and structural imaging were performed in 128 patients with suspected normal pressure hydrocephalus and 44 control participants. Patients were categorized into 4 subgroups based on their anatomic features. Surgery outcome was acquired for 68 patients. Voxelwise modeling was performed to detect regions with significantly different mechanical properties between each group. Mechanical signatures were summarized using pattern analysis and were used as features to train classification models and predict shunt outcomes for 2 sets of feature spaces: a limited 2D feature space that included the most common features found in normal pressure hydrocephalus and an expanded 20-dimensional (20D) feature space that included features from all 4 morphologic subgroups. Results: Both the 2D and 20D classifiers performed significantly better than chance for predicting clinical outcomes with estimated areas under the receiver operating characteristic curve of 0.66 and 0.77, respectively ( P < .05, permutation test). The 20D classifier significantly improved the diagnostic OR and positive predictive value compared with the 2D classifier ( P < .05, permutation test). Conclusions: MR elastography provides further insight into mechanical alterations in the normal pressure hydrocephalus brain and is a promising, noninvasive method for predicting surgical outcomes in patients with normal pressure hydrocephalus. (© 2024 by American Journal of Neuroradiology.) |
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| معلومات مُعتمدة: | R01 AG076636 United States AG NIA NIH HHS; R37 EB001981 United States EB NIBIB NIH HHS; U01 EB024450 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20240125 Date Completed: 20240311 Latest Revision: 20240919 |
| رمز التحديث: | 20240919 |
| مُعرف محوري في PubMed: | PMC11286123 |
| DOI: | 10.3174/ajnr.A8108 |
| PMID: | 38272572 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1936-959X |
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| DOI: | 10.3174/ajnr.A8108 |