دورية أكاديمية
Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models.
العنوان: | Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models. |
---|---|
المؤلفون: | Luss AL; Department of Technology of Chemical, Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Bagrov DV; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Yagolovich AV; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia., Kukovyakina EV; Department of Technology of Chemical, Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Khan II; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 115478 Moscow, Russia.; Department of Biochemistry, People's Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Pokrovsky VS; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 115478 Moscow, Russia.; Department of Biochemistry, People's Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Shestovskaya MV; Department of Technology of Chemical, Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia., Gasparian ME; Department of Technology of Chemical, Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia., Dolgikh DA; Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia., Kuskov AN; Department of Technology of Chemical, Pharmaceutical and Cosmetic Substances, D. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia. |
المصدر: | Pharmaceutics [Pharmaceutics] 2023 Dec 19; Vol. 16 (1). Date of Electronic Publication: 2023 Dec 19. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مستخلص: | Curcumin attracts huge attention because of its biological properties: it is antiproliferative, antioxidant, anti-inflammatory, immunomodulatory and so on. However, its usage has been limited by poor water solubility and low bioavailability. Herein, to solve these problems, we developed curcumin-loaded nanoparticles based on end-capped amphiphilic poly(N-vinylpyrrolidone). Nanoparticles were obtained using the solvent evaporation method and were characterized by dynamic and electrophoretic light scattering, transmission electron (TEM) and atomic force (AFM) microscopy. The average particle size was 200 nm, and the ζ-potential was -4 mV. Curcumin-release studies showed that nanoparticles are stable in aqueous solutions. An in vitro release study showed prolonged action in gastric, intestinal and colonic fluids, consistently, and in PBS. In vitro studies on epidermoid carcinoma and human embryonic kidney cells showed that the cells absorbed more curcumin in nanoparticles compared to free curcumin. Nanoparticles are safe for healthy cells and show high cytotoxicity for glioblastoma cells in cytotoxicity studies in vitro. The median lethal dose was determined in an acute toxicity assay on zebrafish and was 23 μM. Overall, the curcumin-loaded nanoparticles seem promising for cancer treatment. |
References: | Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109883. (PMID: 31500046) Pharmaceutics. 2022 Apr 24;14(5):. (PMID: 35631510) Nanomedicine. 2017 Apr;13(3):943-953. (PMID: 27884638) Adv Drug Deliv Rev. 2016 Dec 15;107:163-175. (PMID: 27426411) Nanomedicine. 2017 Apr;13(3):1021-1030. (PMID: 27884639) Front Plant Sci. 2015 Oct 01;6:799. (PMID: 26483815) Int J Surg. 2017 Aug;44:260-268. (PMID: 28648795) Mol Pharm. 2020 Nov 2;17(11):4212-4225. (PMID: 32986447) Int J Mol Sci. 2022 Mar 20;23(6):. (PMID: 35328780) Prikl Biokhim Mikrobiol. 2008 Nov-Dec;44(6):688-93. (PMID: 19145977) Bioorg Khim. 2013 Jul-Aug;39(4):497-503. (PMID: 24707732) Anticancer Res. 2019 Mar;39(3):1161-1168. (PMID: 30842145) Int J Mol Sci. 2019 Feb 27;20(5):. (PMID: 30818786) Pharmaceutics. 2021 Sep 07;13(9):. (PMID: 34575490) Food Funct. 2020 Jun 24;11(6):5377-5388. (PMID: 32469014) AAPS PharmSciTech. 2021 Jan 6;22(1):34. (PMID: 33404984) Int J Mol Sci. 2022 Feb 12;23(4):. (PMID: 35216149) Langmuir. 2004 Aug 3;20(16):6940-5. (PMID: 15274607) Microsc Res Tech. 2022 Feb;85(2):562-569. (PMID: 34498784) Phytother Res. 2022 Apr;36(4):1616-1632. (PMID: 35302258) Food Chem Toxicol. 2016 Oct;96:273-9. (PMID: 27539747) Adv Colloid Interface Sci. 2022 Feb;300:102582. (PMID: 34953375) ACS Appl Bio Mater. 2022 Jul 18;5(7):3338-3348. (PMID: 35791763) Nanomedicine (Lond). 2023 Jan;18(2):125-143. (PMID: 36916394) J Cell Physiol. 2019 Jul;234(7):10281-10288. (PMID: 30585634) J Biomater Sci Polym Ed. 2014;25(13):1407-24. (PMID: 25072747) Expert Opin Drug Deliv. 2016 Sep;13(9):1257-75. (PMID: 27116988) Clin Cancer Res. 2010 Dec 1;16(23):5781-95. (PMID: 21138870) Curr Neuropharmacol. 2021;19(7):1007-1018. (PMID: 32442088) Eye Contact Lens. 2003 Jan;29(1):38-43. (PMID: 12769155) Mol Pharm. 2007 Nov-Dec;4(6):807-18. (PMID: 17999464) J Drug Target. 2023 Aug;31(7):671-684. (PMID: 37354074) Microsc Res Tech. 2023 Jul;86(7):781-790. (PMID: 37125595) Biomedicines. 2021 Oct 28;9(11):. (PMID: 34829791) ACS Appl Bio Mater. 2021 Aug 16;4(8):6084-6092. (PMID: 35006888) Biomolecules. 2022 Nov 23;12(12):. (PMID: 36551167) Polymers (Basel). 2020 May 13;12(5):. (PMID: 32414187) Bioact Mater. 2022 Apr 23;19:282-291. (PMID: 35574055) Front Bioeng Biotechnol. 2019 Oct 11;7:259. (PMID: 31681741) Molecules. 2020 Oct 20;25(20):. (PMID: 33092261) Pharmaceutics. 2021 May 04;13(5):. (PMID: 34064408) Int J Mol Med. 2010 Jul;26(1):85-94. (PMID: 20514426) Chem Sci. 2014 Aug 30;5(8):3331-3337. (PMID: 25750708) Expert Opin Drug Deliv. 2013 May;10(5):623-38. (PMID: 23387432) Biomedicines. 2022 Oct 04;10(10):. (PMID: 36289740) Food Chem Toxicol. 2019 May;127:42-52. (PMID: 30836108) Nutrients. 2020 Jan 01;12(1):. (PMID: 31906278) J Agric Food Chem. 2019 May 8;67(18):5113-5121. (PMID: 31013074) J Nanobiotechnology. 2012 Aug 31;10:38. (PMID: 22937885) Gels. 2023 Jul 25;9(8):. (PMID: 37623051) Annu Rev Food Sci Technol. 2019 Mar 25;10:597-617. (PMID: 30633561) Adv Drug Deliv Rev. 2016 Apr 1;99(Pt A):28-51. (PMID: 26456916) Curr Pharm Des. 2019;25(3):333-342. (PMID: 30864499) Mar Drugs. 2018 Jun 25;16(7):. (PMID: 29941790) Curr Cancer Drug Targets. 2023;23(7):524-533. (PMID: 36809944) Biomolecules. 2021 Aug 26;11(9):. (PMID: 34572491) Curr Pharm Des. 2023;29(13):1046-1058. (PMID: 36999712) Curr Med Chem. 2021 Oct 25;28(33):6915-6930. (PMID: 34036908) Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834) Materials (Basel). 2022 Oct 13;15(20):. (PMID: 36295201) Pharmaceutics. 2023 Apr 19;15(4):. (PMID: 37111761) Nanomedicine (Lond). 2018 Apr 1;13(7):703-715. (PMID: 29629829) Molecules. 2019 May 27;24(10):. (PMID: 31137865) Adv Drug Deliv Rev. 2022 Jan;180:114079. (PMID: 34902516) Materials (Basel). 2021 Oct 11;14(20):. (PMID: 34683572) Can Anaesth Soc J. 1975 Jan;22(1):12-9. (PMID: 1109702) |
معلومات مُعتمدة: | 23-15-00468 Russian Science Foundation |
فهرسة مساهمة: | Keywords: curcumin; glioblastoma; nanoparticles; poly(N-vinylpyrrolidone); toxicity |
تواريخ الأحداث: | Date Created: 20240126 Latest Revision: 20240129 |
رمز التحديث: | 20240129 |
مُعرف محوري في PubMed: | PMC10818735 |
DOI: | 10.3390/pharmaceutics16010008 |
PMID: | 38276486 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!