دورية أكاديمية
Creating New Antifoulants Using the Tools and Tactics of Medicinal Chemistry.
| العنوان: | Creating New Antifoulants Using the Tools and Tactics of Medicinal Chemistry. |
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| المؤلفون: | Cahill PL; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand., Moodie LWK; Drug Design and Discovery, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, 75123 Uppsala, Sweden., Hertzer C; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand., Pinori E; RISE Research Institutes of Sweden, Division for Material and Production, 504 62 Borås, Sweden., Pavia H; Department of Marine Sciences - Tjärnö, University of Gothenburg, SE-452 96 Strömstad, Sweden., Hellio C; Univ. Brest, Laboratoire des Sciences de l'Environnement MARin (LEMAR), CNRS, IRD, IFREMER, Brest 29285, France., Brimble MA; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand., Svenson J; Cawthron Institute, 98 Halifax Street East, Nelson 7010, New Zealand. |
| المصدر: | Accounts of chemical research [Acc Chem Res] 2024 Feb 06; Vol. 57 (3), pp. 399-412. Date of Electronic Publication: 2024 Jan 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0157313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4898 (Electronic) Linking ISSN: 00014842 NLM ISO Abbreviation: Acc Chem Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
| مواضيع طبية MeSH: | Biofouling*/prevention & control , Disinfectants* , Biological Products*/pharmacology, Animals ; Humans ; Chemistry, Pharmaceutical ; Aquatic Organisms |
| مستخلص: | The unwanted accumulation of marine micro- and macroorganisms such as algae and barnacles on submerged man-made structures and vessel hulls is a major challenge for any marine operation. Known as biofouling, this problem leads to reduced hydrodynamic efficiency, significantly increased fuel usage, microbially induced corrosion, and, if not managed appropriately, eventual loss of both performance and structural integrity. Ship hull biofouling in the international maritime transport network conservatively accounts for 0.6% of global carbon emissions, highlighting the global scale and the importance of this problem. Improved antifouling strategies to limit surface colonization are paramount for essential activities such as shipping, aquaculture, desalination, and the marine renewable energy sector, representing both a multibillion dollar cost and a substantial practical challenge. From an ecological perspective, biofouling is a primary contributor to the global spread of invasive marine species, which has extensive implications for the marine environment.Historically, heavy metal-based toxic biocides have been used to control biofouling. However, their unwanted collateral ecological damage on nontarget species and bioaccumulation has led to recent global bans. With expanding human activities within aquaculture and offshore energy, it is both urgent and apparent that environmentally friendly surface protection remains key for maintaining the function of both moving and stationary marine structures. Biofouling communities are typically a highly complex network of both micro- and macroorganisms, representing a broad section of life from bacteria to macrophytes and animals. Given this diversity, it is unrealistic to expect that a single antifouling "silver bullet" will prevent colonization with the exception of generally toxic biocides. For that reason, modern and future antifouling solutions are anticipated to rely on novel coating technologies and "combination therapies" where mixtures of narrow-spectrum bioactive components are used to provide coverage across fouling species. In contrast to the existing cohort of outdated, toxic antifouling strategies, such as copper- and tributyltin-releasing paints, modern drug discovery techniques are increasingly being employed for the rational design of effective yet safe alternatives. The challenge for a medicinal chemistry approach is to effectively account for the large taxonomic diversity among fouling organisms combined with a lack of well-defined conserved molecular targets within most taxa.The current Account summarizes our work employing the tools of modern medicinal chemistry to discover, modify, and develop optimized and scalable antifouling solutions based on naturally occurring antifouling and repelling compounds from both marine and terrestrial sources. Inspiration for rational design comes from targeted studies on allelopathic natural products, natural repelling peptides, and secondary metabolites from sessile marine organisms with clean exteriors, which has yielded several efficient and promising antifouling leads. |
| المشرفين على المادة: | 0 (Disinfectants) 0 (Biological Products) |
| تواريخ الأحداث: | Date Created: 20240126 Date Completed: 20240207 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| DOI: | 10.1021/acs.accounts.3c00733 |
| PMID: | 38277792 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-4898 |
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| DOI: | 10.1021/acs.accounts.3c00733 |