دورية أكاديمية
Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review.
| العنوان: | Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review. |
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| المؤلفون: | Gudavalli D; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India., Pandey K; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India., Ede VG; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India., Sable D; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India., Ghagare AS; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India., Kate AS; Department of Natural Products, National Institute of Pharmaceutical Education and Research, Ahmedabad, Gandhinagar, Gujarat 382355, India. Electronic address: abhijeetk@niperahm.ac.in. |
| المصدر: | Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105830. Date of Electronic Publication: 2024 Jan 28. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| مواضيع طبية MeSH: | Bauhinia*/chemistry, Molecular Structure ; Medicine, Traditional ; Phytotherapy ; Flavonoids ; Phytochemicals/pharmacology ; Phytochemicals/analysis ; Ethnopharmacology ; Plant Extracts/pharmacology |
| مستخلص: | Genus Bauhinia has been widely used in the treatment of diabetes, malaria, cough, headache, fever, piles, dysentery, flatulence, diarrhoea, ulcer and cardiovascular problems. Among 600 species of this genus, Bauhinia variegata, B. purpurea, B. championii, B. racemosa, and B. forficata are commonly used in the traditional medicine and found to be throughly investigated for their medicinal properties. They possess diverse pharmacological activities such as anti-diabetic, anti-microbial, antioxidant, anti-arthritic, cardioprotective, hepatoprotective, nephroprotective, fibrinolytic, and wound healing properties and most of the biological activities are corelating with traditional knowledge. Phytochemical analysis indicated that steroids, terpenoids, and flavonoids are prominent in the selected species, whereas bauhiniastatins, bauhinoxepins, racemosols, roseosides, and bauhichamines are found unique to the genus. This review aims to decipher active molecules from the aforementioned species of Bauhinia covering comprehensive analysis of phytochemistry, pharmacological activities and traditional uses. The data has been carefully analyzed to find compounds or fractions with a translational value. In most of the cases, the pharmacological activities have been established, however, further studies are needed such as safety evaluations, target identification, bioavailability, metabolite identification, and pharmacokinetic properties. In conclusion, the pharmacological potential of Bauhinia plants show promise with various leads such as insulin-like protein, roseoside, bauhiniastatin, and melibiose binding lectin. However, further investigations are required to address existing gaps and advance them towards product development. This review will lay the groundwork for future research initiatives aimed at fully realizing the therapeutic potential of Bauhinia plants. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bauhinia; Bauhiniastatin 1; Fabaceae; Insulin like protein; Kanchanara; Roseoside |
| المشرفين على المادة: | 0 (Flavonoids) 0 (Phytochemicals) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20240129 Date Completed: 20240325 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| DOI: | 10.1016/j.fitote.2024.105830 |
| PMID: | 38286316 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6971 |
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| DOI: | 10.1016/j.fitote.2024.105830 |