دورية أكاديمية
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications.
| العنوان: | Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications. |
|---|---|
| المؤلفون: | Sterenborg RBTM; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Steinbrenner I; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Li Y; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Bujnis MN; The University of Utah, Salt Lake City, UT, USA., Naito T; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Marouli E; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Digital Environment Research Institute, Queen Mary University of London, London, UK., Galesloot TE; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands., Babajide O; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Andreasen L; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Astrup A; Department of Obesity and Nutritional Sciences, The Novo Nordisk Foundation, Hellerup, Denmark., Åsvold BO; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Bandinelli S; Geriatric Unit, Azienda Sanitaria Toscana Centro, Florence, Italy., Beekman M; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Beilby JP; School of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Boutin T; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brown SJ; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia., Brumpton B; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, 7600, Norway., Campbell PJ; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia., Cappola AR; Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania, Philadelphia, PA, USA., Ceresini G; Oncological Endocrinology, University of Parma, Parma, Italy.; Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., Chaker L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy., Coutinho de Almeida R; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Cross SM; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Cucca F; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy.; Università di Sassari, Dipartimento di Scienze Biomediche, V.le San Pietro, 07100, Sassari (SS), Italy., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Kjaergaard AD; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Blvd. 11, Entrance A, 8200, Aarhus, Denmark., Echouffo Tcheugui JB; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA., Ellervik C; Harvard Medical School, Boston, USA.; Faculty of Medical Science, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark., Eriksson JG; Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland.; National University Singapore, Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology, Singapore, Singapore., Ferrucci L; Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Freudenberg J; Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA., Fuchsberger C; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Gieger C; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA., Gögele M; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Graham SE; Department of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gunjača I; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harding BN; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Barcelona Institute for Global Health, Barcelona, Spain., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Haunsø S; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom., Hui J; Pathwest Laboratory Medicine WA, Nedlands, WA, 6009, Australia.; School of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia., Ittermann T; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kajantie E; Finnish Institute for Health and Welfare, Population Health Unit, Helsinki and Oulu, Oulu, Finland.; Clinical Medicine Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Kanters JK; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center of Physiological Research, University of California San Francisco, San Francisco, USA., Kårhus LL; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Kiemeney LALM; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands., Kloppenburg M; Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Kühnel B; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Lapauw B; Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium., Leese G; NHS Tayside, Scotland, Dundee, UK., Li S; Department of Biostatistics, Boston University, Boston, MA, USA., Liewald DCM; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Linneberg A; Center of Physiological Research, University of California San Francisco, San Francisco, USA.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lominchar JVT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Matana A; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia., Meima ME; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Meitinger T; Institute for Human Genetics, Technical University of Munich, Munich, Germany., Meulenbelt I; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Mitchell BD; University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, 21201, USA., Møllehave LT; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Mora S; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Naitza S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Nauck M; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Netea-Maier RT; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Nursyifa C; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan., Onano S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Papadopoulou A; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Palmer CNA; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Pattaro C; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Metabolic Research, Herlev-Gentofte University Hospital, Copenhagen, Denmark., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany., Pietzner M; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.; Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Polašek O; Department of Public Health, University of Split, School of Medicine, Split, Croatia.; Algebra University College, Zagreb, Croatia., Pramstaller PP; Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research, Bolzano, Italy., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Departments of Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA., Punda A; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Redmond P; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom., Richards JB; Lady Davis Institute, Jewish General Hospital, Montreal, Quebec, H3T 1E2, Canada., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA.; Harvard Medical School, Boston, USA., Russ TC; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, United Kingdom.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom., Ryan KA; University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition, Baltimore, USA., Olesen MS; Laboratory for Molecular Cardiology, Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark., Schultheiss UT; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Medicine IV - Nephrology and Primary Care, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Siddiqui MK; Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, 09042, Monserrato (CA), Italy., Slagboom PE; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Sørensen TIA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Soto-Pedre E; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Spector TD; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK., Spedicati B; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy., Srinivasan S; Division of Population Health Genomics, School of Medicine, University of Dundee, DD19SY, Dundee, UK., Starr JM; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Tanaka T; Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Torlak V; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Tuhkanen J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Uitterlinden AG; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., van den Akker EB; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Computational Biology Center, Leiden University Medical Center, Leiden, The Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands., van den Eynde T; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., van der Klauw MM; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Verroken C; Department of Endocrinology, Ghent University Hospital, C. Heymanslaan 10, 9000, Ghent, Belgium., Visser WE; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Vojinovic D; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands., Völzke H; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany., Walsh JP; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.; Medical School, The University of Western Australia, Crawley, WA, 6009, Australia., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Weiss S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Willer CJ; Department of Internal Medicine, Cardiology, University of Michigan, Ann Arbor, MI, 48109, USA., Wilson SG; School of Biomedical Sciences, The University of Western Australia, Perth, WA, 6009, Australia.; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Lambeth Palace Road, London, SE1 7EH, UK., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wouters HJCM; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wright MJ; Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia., Yang Q; Department of Biostatistics, Boston University, Boston, MA, USA., Zemunik T; Department of Medical Biology, University of Split, School of Medicine, Split, Croatia.; Department of Nuclear Medicine, University Hospital Split, Split, Croatia., Zhou W; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA., Smit JWA; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands., Peeters RP; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.; CIBSS - Centre for Integrative Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, 17475, Greifswald, Germany. ateumer@uni-greifswald.de.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de.; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. ateumer@uni-greifswald.de., Medici M; Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Nijmegen, The Netherlands. m.medici@erasmusmc.nl.; Academic Center for Thyroid Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. m.medici@erasmusmc.nl. |
| مؤلفون مشاركون: | GHS DiscovEHR, Regeneron Genetics Center |
| المصدر: | Nature communications [Nat Commun] 2024 Jan 30; Vol. 15 (1), pp. 888. Date of Electronic Publication: 2024 Jan 30. |
| نوع المنشور: | Meta-Analysis; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Thyroid Gland*/metabolism , Thyroxine*/metabolism, Humans ; Genome-Wide Association Study ; Triiodothyronine/metabolism ; Thyrotropin/metabolism |
| مستخلص: | To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases. (© 2024. The Author(s).) |
| References: | PLoS One. 2021 Sep 3;16(9):e0256988. (PMID: 34478452) J Clin Endocrinol Metab. 2008 Aug;93(8):3075-81. (PMID: 18492748) Genet Epidemiol. 2008 May;32(4):381-5. (PMID: 18348202) Nat Genet. 2012 Mar 18;44(4):369-75, S1-3. (PMID: 22426310) Thyroid. 2014 Dec;24(12):1670-751. (PMID: 25266247) Circ Res. 2017 Dec 8;121(12):1392-1400. (PMID: 29089349) Endocr Rev. 2005 Aug;26(5):704-28. (PMID: 15632316) Genet Epidemiol. 2013 Nov;37(7):658-65. (PMID: 24114802) Thyroid. 2016 Oct;26(10):1457-1465. (PMID: 27539006) Genet Epidemiol. 2016 May;40(4):304-14. (PMID: 27061298) Cancer. 2005 Mar 15;103(6):1122-8. (PMID: 15712375) Endocrinol Metab (Seoul). 2022 Apr;37(2):208-219. (PMID: 35417936) J Clin Endocrinol Metab. 2002 Mar;87(3):1068-72. (PMID: 11889165) Nat Commun. 2015 Mar 06;6:5681. (PMID: 25743335) Mol Psychiatry. 2021 Aug;26(8):4179-4190. (PMID: 31712720) PLoS Comput Biol. 2015 Apr 17;11(4):e1004219. (PMID: 25885710) Nat Commun. 2017 Feb 14;8:14517. (PMID: 28195142) Nat Rev Genet. 2016 Mar;17(3):160-74. (PMID: 26907721) J Clin Endocrinol Metab. 2013 Sep;98(9):3562-71. (PMID: 23824418) Curr Genomics. 2007 Nov;8(7):453-65. (PMID: 19412418) J Clin Endocrinol Metab. 2015 Oct;100(10):3718-24. (PMID: 26262438) Arch Intern Med. 2012 May 28;172(10):799-809. (PMID: 22529182) Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):570-4. (PMID: 19155436) Hum Mol Genet. 2018 Oct 15;27(20):3641-3649. (PMID: 30124842) Nat Genet. 2019 Jun;51(6):957-972. (PMID: 31152163) Int J Epidemiol. 2017 Dec 1;46(6):1985-1998. (PMID: 29040600) Nat Genet. 2015 Mar;47(3):291-5. (PMID: 25642630) Elife. 2018 May 30;7:. (PMID: 29846171) Genes Immun. 2008 Apr;9(3):267-70. (PMID: 18273036) Eur J Endocrinol. 2014 Nov;171(5):R197-208. (PMID: 25005935) Mol Hum Reprod. 2005 Aug;11(8):591-600. (PMID: 16051677) Nat Genet. 2015 Nov;47(11):1236-41. (PMID: 26414676) Nat Genet. 2018 May;50(5):668-681. (PMID: 29700475) J Clin Endocrinol Metab. 2020 Jun 1;105(6):. (PMID: 32271924) J Clin Endocrinol Metab. 2020 Aug 1;105(8):. (PMID: 32374820) Am J Hum Genet. 2010 Sep 10;87(3):430-5. (PMID: 20826269) Annu Rev Genomics Hum Genet. 2013;14:301-23. (PMID: 23875801) Nat Rev Genet. 2019 Mar;20(3):173-190. (PMID: 30581192) Bioinformatics. 2014 Feb 15;30(4):523-30. (PMID: 24336805) Eur J Endocrinol. 2014 Nov;171(5):593-602. (PMID: 25305308) Nat Genet. 2018 Sep;50(9):1225-1233. (PMID: 29892015) Endocr Rev. 2015 Apr;36(2):214-44. (PMID: 25751422) Nat Commun. 2018 Oct 26;9(1):4455. (PMID: 30367059) Int J Cancer. 2020 Oct 1;147(7):1895-1903. (PMID: 32215913) Nat Commun. 2021 Jan 28;12(1):654. (PMID: 33510174) Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253) Nat Genet. 2018 May;50(5):693-698. (PMID: 29686387) J Clin Endocrinol Metab. 2014 Apr;99(4):1213-9. (PMID: 24564323) Nat Rev Endocrinol. 2018 May;14(5):301-316. (PMID: 29569622) Circ Genom Precis Med. 2019 Mar;12(3):e002468. (PMID: 30702347) J Clin Endocrinol Metab. 2013 Jul;98(7):2936-43. (PMID: 23671314) Am J Hum Genet. 2011 Jan 7;88(1):76-82. (PMID: 21167468) Oncotarget. 2015 May 10;6(13):11242-51. (PMID: 25803323) J Clin Endocrinol Metab. 2022 May 17;107(6):e2276-e2283. (PMID: 35262175) Nature. 2021 Dec;600(7890):675-679. (PMID: 34887591) J Endocrinol Invest. 2019 Oct;42(10):1171-1180. (PMID: 30843173) Cancer Lett. 2003 Mar 10;191(2):193-202. (PMID: 12618333) Nat Commun. 2017 Nov 28;8(1):1826. (PMID: 29184056) Nat Genet. 2022 May;54(5):560-572. (PMID: 35551307) J Clin Endocrinol Metab. 2004 Mar;89(3):1181-7. (PMID: 15001606) Nat Commun. 2015 Jan 19;6:5890. (PMID: 25597830) BMJ. 2012 Nov 27;345:e7895. (PMID: 23186910) Eur J Endocrinol. 2016 Apr;174(4):409-14. (PMID: 26863886) J Clin Endocrinol Metab. 2015 Jun;100(6):2181-91. (PMID: 25856213) Nat Commun. 2020 Jan 9;11(1):163. (PMID: 31919418) BMC Med. 2016 Sep 30;14(1):150. (PMID: 27686165) JAMA Cardiol. 2019 Feb 1;4(2):144-152. (PMID: 30673084) PLoS Genet. 2022 Jul 19;18(7):e1010299. (PMID: 35853082) Nat Genet. 2015 Oct;47(10):1121-1130. (PMID: 26343387) J Thyroid Res. 2016;2016:6351473. (PMID: 27123359) Nature. 2018 Oct;562(7726):203-209. (PMID: 30305743) Thyroid. 2021 May;31(5):721-731. (PMID: 32746749) Nature. 2007 Jun 7;447(7145):661-78. (PMID: 17554300) J Endocrinol. 1963 Jun;26:331-8. (PMID: 13944118) Nat Genet. 2018 Jul;50(7):912-919. (PMID: 29942086) Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E75-81. (PMID: 15727947) PLoS Genet. 2011 Jul;7(7):e1002091. (PMID: 21750679) Arch Intern Med. 2005 Nov 28;165(21):2460-6. (PMID: 16314541) Front Endocrinol (Lausanne). 2015 Nov 20;6:177. (PMID: 26635726) Nat Genet. 2018 Oct;50(10):1412-1425. (PMID: 30224653) J Endocrinol. 1960 Nov;21:241-6. (PMID: 13736410) Oncogene. 2020 Oct;39(43):6719-6732. (PMID: 32963352) Gen Pharmacol. 1997 Jan;28(1):13-22. (PMID: 9112071) Nat Genet. 2019 Mar;51(3):404-413. (PMID: 30617256) BMC Med. 2021 Nov 3;19(1):266. (PMID: 34727949) J Clin Endocrinol Metab. 2016 Nov;101(11):4270-4282. (PMID: 27603906) J Cancer Res Clin Oncol. 2021 Jan;147(1):183-194. (PMID: 32995956) Thyroid. 2005 Mar;15(3):279-85. (PMID: 15785248) Nature. 2020 Aug;584(7822):619-623. (PMID: 32581359) Nat Genet. 2018 Apr;50(4):621-629. (PMID: 29632380) Nat Genet. 2021 Jun;53(6):817-829. (PMID: 34002096) Sci Rep. 2018 Oct 12;8(1):15186. (PMID: 30315195) Respir Res. 2019 Apr 2;20(1):64. (PMID: 30940143) Hum Mol Genet. 2019 Jan 1;28(1):166-174. (PMID: 30239722) Nat Genet. 2018 Apr;50(4):524-537. (PMID: 29531354) PLoS One. 2012;7(10):e47730. (PMID: 23118893) J Clin Endocrinol Metab. 2015 Mar;100(3):1088-96. (PMID: 25514105) Heart Fail Rev. 2009 Dec;14(4):321-9. (PMID: 19101795) Nat Commun. 2020 Aug 7;11(1):3981. (PMID: 32769997) Endocrinology. 2023 Feb 11;164(4):. (PMID: 36791033) J Hum Genet. 2019 May;64(5):473-480. (PMID: 30824882) Nat Genet. 2019 Feb;51(2):258-266. (PMID: 30598549) Circulation. 2017 Nov 28;136(22):2100-2116. (PMID: 29061566) Mol Genet Genomic Med. 2021 Feb;9(2):e1571. (PMID: 33554479) |
| معلومات مُعتمدة: | T32 DK110966 United States DK NIDDK NIH HHS; R35 GM118335 United States GM NIGMS NIH HHS; K24 AG042765 United States AG NIA NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; MC_UU_00007/10 United Kingdom MRC_ Medical Research Council; R01 AG032317 United States AG NIA NIH HHS |
| المشرفين على المادة: | Q51BO43MG4 (Thyroxine) 06LU7C9H1V (Triiodothyronine) 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20240130 Date Completed: 20240201 Latest Revision: 20240313 |
| رمز التحديث: | 20240313 |
| مُعرف محوري في PubMed: | PMC10828500 |
| DOI: | 10.1038/s41467-024-44701-9 |
| PMID: | 38291025 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
|---|---|
| DOI: | 10.1038/s41467-024-44701-9 |