دورية أكاديمية
κ-Carrageenan/sericin polymer matrix modified with different crosslinking agents and thermal crosslinking: Improved release profile of mefenamic acid.
| العنوان: | κ-Carrageenan/sericin polymer matrix modified with different crosslinking agents and thermal crosslinking: Improved release profile of mefenamic acid. |
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| المؤلفون: | Vieira WT; University of Campinas, School of Chemical Engineering, Albert Einstein Av. 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., Nicolini MVS; University of Campinas, School of Chemical Engineering, Albert Einstein Av. 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., da Silva MGC; University of Campinas, School of Chemical Engineering, Albert Einstein Av. 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., Nascimento LO; University of Campinas, School of Pharmaceutical Sciences, Cândido Portinari, St. 200, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-871, Brazil., Vieira MGA; University of Campinas, School of Chemical Engineering, Albert Einstein Av. 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil. Electronic address: melissag@unicamp.br. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 262 (Pt 1), pp. 129823. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Sericins*/chemistry, Mefenamic Acid/pharmacology ; Polymers ; Carrageenan/chemistry ; Drug Liberation ; Delayed-Action Preparations/chemistry |
| مستخلص: | The crosslinking of the polymer matrix with compatible macromolecules results in a three-dimensional network structure that offers an enhancement in the controlled release properties of the material. In this sense, this work aimed to improve the release profile of mefenamic acid (MAC) through crosslinking strategies. κ-Carrageenan/sericin crosslinked blend was obtained by covalent and thermal crosslinking and the different formulations were characterized. The gastroresistant potential and release profile were evaluated in the dissolution assay. The effect and characterization of the particles were investigated. Multiple units presented high entrapment efficiency (94.11-104.25), high drug loading (36.50-47.50 %) and adequate particle size (1.34-1.57 mm) with rough surface and visually spherical shape. The Weibull model showed that drug release occurred by relaxation, erosion and Fickian diffusion. Material stability and absence of MAC -polymer interactions were demonstrated by FTIR and thermogravimetric analysis. DSC showed a stable character of MAC in the drug-loaded beads. Moreover, the application studies of κ-Car/Ser/carboxymethylcellulose in the in vitro intestine mode showed that the crosslinked blend increased cell viability (>85 %), while free MAC exhibited a cytotoxic effect. Finally, the crosslinked k-Car/Ser blend MAC -loaded showed promising properties of a sustained release form of anti-inflammatory drug. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-inflammatory; Cell viability; Drug delivery; Extended release |
| المشرفين على المادة: | 0 (Sericins) 367589PJ2C (Mefenamic Acid) 0 (Polymers) 9000-07-1 (Carrageenan) 0 (Delayed-Action Preparations) |
| تواريخ الأحداث: | Date Created: 20240131 Date Completed: 20240320 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| DOI: | 10.1016/j.ijbiomac.2024.129823 |
| PMID: | 38296146 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2024.129823 |