دورية أكاديمية
أعرض في EDS

Ethambutol and its ophthalmic effects; is screening and collaboration the new way forward?

التفاصيل البيبلوغرافية
العنوان: Ethambutol and its ophthalmic effects; is screening and collaboration the new way forward?
المؤلفون: Vyas A; Vitreo-retina Department, K B H Bachooali Charitable Ophthalmic & ENT Hospital, Mumbai, Maharashtra, India., Subramanyam A; Vitreo-retina Department, K B H Bachooali Charitable Ophthalmic & ENT Hospital, Mumbai, Maharashtra, India. Electronic address: mumbairetinadoc@gmail.com., Phatak S; Vitreo-retina Department, K B H Bachooali Charitable Ophthalmic & ENT Hospital, Mumbai, Maharashtra, India., Tiwari S; Vitreo-retina Department, K B H Bachooali Charitable Ophthalmic & ENT Hospital, Mumbai, Maharashtra, India.
المصدر: The Indian journal of tuberculosis [Indian J Tuberc] 2024 Jan; Vol. 71 (1), pp. 30-34. Date of Electronic Publication: 2023 Mar 24.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: India NLM ID: 0373027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0019-5707 (Print) Linking ISSN: 00195707 NLM ISO Abbreviation: Indian J Tuberc Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2015- : New Delhi : Elsevier
Original Publication: New Delhi, Tuberculosis Assn. of India.
مواضيع طبية MeSH: Ethambutol*/adverse effects , Optic Nerve Diseases*/chemically induced , Optic Nerve Diseases*/diagnosis, Humans ; Antitubercular Agents/adverse effects ; Evoked Potentials, Visual ; Retrospective Studies ; Toxic Optic Neuropathy/drug therapy ; Vision Disorders/chemically induced
مستخلص: Aim: To screen patients on ethambutol and evaluate its role on visual functions and toxic optic neuropathy.
Setting and Design: Retrospective, observational single tertiary centre cohort of 80 patients.
Methods and Material: A total of 69 from the initial 80 patients with visual complaints were categorised into two groups A and B; ongoing anti-tubercular therapy with ethambutol and having stopped ethambutol for greater than six months respectively. All patients underwent vision (V) testing on ETDRS chart and anterior and posterior segment evaluation. Additionally, patients in group A recorded color vision (CV) on Ishihara chart and visual evoked potential (VEP).
Statistical Analysis Used: P value was calculated using Chi square test (SPSS ver. 20).
Results: Out of 69 patients in our study, 58 (84.05%) patients recorded reduced visual acuity. The mean visual acuity was 0.58 logMAR units. 33 out of our 58 (57%) patients with reduced visual acuity showed normal optic discs while 25 out of 58 (43%) showed altered optic discs. In group B, 14 out of 32 patients with vision of less than 20/20 also had optic disc pallor (p = 0.02). 12 out of 15 patients in group A recorded an altered color vision and also had a vision of less than 20/20 (p = 0.023). 15 patients who recorded altered VEP also had vision of less than 20/20 (p = 0.037).
Conclusion: Visual acuity, color vision and vep are sensitive and sustainable tools which can be implemented in regular screening. Ethambutol toxicity is a real problem and a collaborative approach is necessary to establish screening protocols and prevent ethambutol induced toxic optic neuropathy.
Competing Interests: Conflicts of interest The authors have none to declare.
(Copyright © 2023 Tuberculosis Association of India. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Color vision; Ethambutol; Screening; Toxic optic neuropathy; Visual evoked potential
المشرفين على المادة: 0 (Antitubercular Agents)
8G167061QZ (Ethambutol)
تواريخ الأحداث: Date Created: 20240131 Date Completed: 20240214 Latest Revision: 20240226
رمز التحديث: 20240226
DOI: 10.1016/j.ijtb.2023.03.009
PMID: 38296388
قاعدة البيانات: MEDLINE
الوصف
تدمد:0019-5707
DOI:10.1016/j.ijtb.2023.03.009