دورية أكاديمية
Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial.
| العنوان: | Efficacy of ceramides and niacinamide-containing moisturizer versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris: A split face, double-blinded, randomized controlled trial. |
|---|---|
| المؤلفون: | Tempark T; Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand., Shem A; M. Yamin Clinic and Pharmacy JI. M. Yamin, Samarinda, Indonesia., Lueangarun S; Department of Aesthetic Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand.; Division of Dermatology, DeMed Clinic Center, Bangkok, Thailand. |
| المصدر: | Journal of cosmetic dermatology [J Cosmet Dermatol] 2024 May; Vol. 23 (5), pp. 1758-1765. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Comparative Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 101130964 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-2165 (Electronic) Linking ISSN: 14732130 NLM ISO Abbreviation: J Cosmet Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Blackwell Science, c2002- |
| مواضيع طبية MeSH: | Acne Vulgaris*/drug therapy , Niacinamide*/administration & dosage , Niacinamide*/adverse effects , Skin Cream*/administration & dosage , Skin Cream*/adverse effects , Ceramides*/administration & dosage , Severity of Illness Index* , Administration, Cutaneous* , Dermatologic Agents*/administration & dosage , Dermatologic Agents*/adverse effects , Adapalene*/administration & dosage, Humans ; Double-Blind Method ; Female ; Male ; Young Adult ; Adult ; Treatment Outcome ; Adolescent ; Benzoyl Peroxide/administration & dosage ; Benzoyl Peroxide/adverse effects ; Drug Therapy, Combination ; Emollients/administration & dosage ; Drug Combinations |
| مستخلص: | Introduction: Topical therapy is the mainstay treatment of acne, and topical retinoids such as tretinoin, tazarotene, and adapalene are recommended as the first-line therapy for mild to moderate acne. However, the cutaneous irritations may occur, and the dermocosmetics are recommended to prevent side effects of anti-acne drugs and adhere to treatment. Thus, this study aims to compare the efficacy and tolerability of ceramides and niacinamide-containing moisturizer (CCM) versus hydrophilic cream in combination with topical anti-acne treatment in mild to moderate acne vulgaris. Methods: This was an 8-week, randomized, double-blinded, split face study in 40 patients assigned for topical anti-acne medications (5% benzoyl peroxide and 0.1% adapalene gel), then randomly applied CCM or hydrophilic cream. All patients were followed at week 0, 2, 4, and 8 for acne improvement, adverse reactions, biometric, and biophysical evaluation. Results: CCM could significantly improve the non-inflammatory, inflammatory, and total acne lesions compared with hydrophilic cream after week 8 of treatment. Interestingly, there was an improvement of global worst score, hemoglobin index, melanin index, TEWL, skin hydration, sebum production, and skin surface pH, with no statistically significant differences between the two treatments. No serious side effects from clinical application of CCM and hydrophilic cream in mild to moderate acne vulgaris patients. Conclusion: Ceramide and niacinamide-containing moisturizer in combination with anti-acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris. (© 2024 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.) |
| References: | Gollnick H, Cunliffe W, Berson D, et al. Management of acne: a report from a global Alliance to improve outcomes in acne. J Am Acad Dermatol. 2003;49(1 Suppl):S1‐S37. Cunliffe WJ, Poncet M, Loesche C, Verschoore M. A comparison of the efficacy and tolerability of adapalene 0.1% gel versus tretinoin 0.025% gel in patients with acne vulgaris: a meta‐analysis of five randomized trials. Br J Dermatol. 1998;139(Suppl 52):48‐56. Waugh J, Noble S, Scott LJ. Adapalene: a review of its use in the treatment of acne vulgaris. Drugs. 2004;64(13):1465‐1478. Clucas A, Verschoore M, Sorba V, Poncet M, Baker M, Czernielewski J. Adapalene 0.1% gel is better tolerated than tretinoin 0.025% gel in acne patients. J Am Acad Dermatol. 1997;36(6 Pt 2):S116‐S118. Lueangarun S, Sriviriyakul K, Tempark T, Managit C, Sithisarn P. Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild‐to‐moderate acne vulgaris: a 12‐week, split‐face, double‐blinded, randomized, controlled trial. J Cosmet Dermatol. 2019;18(5):1395‐1403. Angelova‐Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double‐blind, randomized, vehicle‐controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. J Eur Acad Dermatol Venereol. 2013;27(Suppl 2):6‐11. Araviiskaia E, Dreno B. The role of topical dermocosmetics in acne vulgaris. J Eur Acad Dermatol Venereol. 2016;30(6):926‐935. Lueangarun S, Tragulplaingam P, Sugkraroek S, Tempark T. The 24‐hr, 28‐day, and 7‐day post‐moisturizing efficacy of ceramides 1, 3, 6‐II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment. Dermatol Ther. 2019;32(6):e13090. Matsunaga K, Leow YH, Chan R, Kerrouche N, Paliargues F. Adjunctive usage of a non‐comedogenic moisturizer with adapalene gel 0.1% improves local tolerance: a randomized, investigator‐blinded, split‐face study in healthy Asian subjects. J Dermatolog Treat. 2013;24(4):278‐282. Chularojanamontri L, Tuchinda P, Kulthanan K, Varothai S, Winayanuwattikun W. A double‐blinded, randomized, vehicle‐controlled study to access skin tolerability and efficacy of an anti‐inflammatory moisturizer in treatment of acne with 0.1% adapalene gel. J Dermatolog Treat. 2016;27(2):140‐145. Yamamoto A, Takenouchi K, Ito M. Impaired water barrier function in acne vulgaris. Arch Dermatol Res. 1995;287(2):214‐218. Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT. Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. J Invest Dermatol. 1988;90(3):350‐353. Li Q, Fang H, Dang E, Wang G. The role of ceramides in skin homeostasis and inflammatory skin diseases. J Dermatol Sci. 2020;97(1):2‐8. Isoda K, Seki T, Inoue Y, et al. Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin. J Dermatol. 2015;42(2):181‐188. Lynde CW, Andriessen A, Barankin B, et al. Moisturizers and ceramide‐containing moisturizers may offer concomitant therapy with benefits. J Clin Aesthet Dermatol. 2014;7(3):18‐26. Draelos ZD. The effect of ceramide‐containing skin care products on eczema resolution duration. Cutis. 2008;81(1):87‐91. Pavicic T, Wollenweber U, Farwick M, Korting HC. Anti‐microbial and inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int J Cosmet Sci. 2007;29(3):181‐190. Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006;8(2):96‐101. Walocko FM, Eber AE, Keri JE, Al‐Harbi MA, Nouri K. The role of nicotinamide in acne treatment. Dermatol Ther. 2017;30(5):e12481. Shalita AR, Smith JG, Parish LC, Sofman MS, Chalker DK. Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995;34(6):434‐437. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M. Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005;44(3):197‐202. Navarrete‐Solis J, Castanedo‐Cazares JP, et al. A double‐blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract. 2011;2011:379173. Sitohang IBS, Yahya YF, Simanungkalit R, Adi Winarni DR, Madjid A. Efficacy and tolerability of topical nicotinamide plus antibacterial adhesive agents and zinc‐pyrrolidone carboxylic acid versus placebo as an adjuvant treatment for moderate acne vulgaris in Indonesia: a multicenter, double‐blind, randomized, Controlled Trial. J Clin Aesthet Dermatol. 2020;13(7):27‐31. Levin J, Momin SB. How much do we really know about our favorite cosmeceutical ingredients? J Clin Aesthet Dermatol. 2010;3(2):22‐41. Thiboutot D, Del Rosso JQ. Acne vulgaris and the epidermal barrier: is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and/or functional integrity of the epidermal barrier? J Clin Aesthet Dermatol. 2013;6(2):18‐24. Bhat YJ, Latief I, Hassan I. Update on etiopathogenesis and treatment of acne. Indian J Dermatol Venereol Leprol. 2017;83(3):298‐306. Prakash C, Bhargava P, Tiwari S, Majumdar B, Bhargava RK. Skin surface pH in acne vulgaris: insights from an observational study and review of the literature. J Clin Aesthet Dermatol. 2017;10(7):33‐39. Schreml S, Kemper M, Abels C. Skin pH in the elderly and appropriate skin care. Eur Med J Dermatol. 2014;2:86. |
| فهرسة مساهمة: | Keywords: acne treatment; ceramides; moisturizer; niacinamide; randomized controlled trial |
| المشرفين على المادة: | 25X51I8RD4 (Niacinamide) 0 (Ceramides) 0 (Dermatologic Agents) 1L4806J2QF (Adapalene) W9WZN9A0GM (Benzoyl Peroxide) 0 (Emollients) 0 (Drug Combinations) |
| تواريخ الأحداث: | Date Created: 20240201 Date Completed: 20240424 Latest Revision: 20240502 |
| رمز التحديث: | 20240503 |
| DOI: | 10.1111/jocd.16212 |
| PMID: | 38299457 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-2165 |
|---|---|
| DOI: | 10.1111/jocd.16212 |