دورية أكاديمية
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A novel approach to quantifying individual's biological aging using Korea's national health screening program toward precision public health.

التفاصيل البيبلوغرافية
العنوان: A novel approach to quantifying individual's biological aging using Korea's national health screening program toward precision public health.
المؤلفون: Yoo J; YooJin BioSoft, 24, Jeongbalsan-Ro Ilsandong-Gu, Goyang-Si Gyeonggi-Do, 10402, Korea., Hur J; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA., Yoo J; YooJin BioSoft, 24, Jeongbalsan-Ro Ilsandong-Gu, Goyang-Si Gyeonggi-Do, 10402, Korea., Jurivich D; Department of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58202, USA., Lee KJ; Department of Women's Rehabilitation, National Rehabilitation Center, 58, Samgaksan-Ro, Gangbuk-Gu, Seoul, 01022, Korea. drlkj4094@korea.kr.; Institute for Occupational & Environmental Health, Korea University, Seoul, 02841, Korea. drlkj4094@korea.kr.
المصدر: GeroScience [Geroscience] 2024 Jun; Vol. 46 (3), pp. 3387-3403. Date of Electronic Publication: 2024 Feb 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cham : Springer International Publishing, [2017]-
مواضيع طبية MeSH: Public Health* , Aging*/physiology, Humans ; Aged ; Proportional Hazards Models ; Biomarkers ; Republic of Korea
مستخلص: Accurate prediction of biological age can inform public health measures to extend healthy lifespans and reduce chronic conditions. Multiple theoretical models and methods have been developed; however, their applicability and accuracy are still not extensive. Here, we report Differential Aging and Health Index (DAnHI), a novel measure of age deviation, developed using physical and serum biomarkers from four million individuals in Korea's National Health Screening Program. Participants were grouped into aging statuses (< 26 vs. ≥ 26, < 27 vs. ≥ 27, …, < 75 vs. ≥ 75 years) as response variables in a binary logistic regression model with thirteen biomarkers as independent variables. DAnHI for each individual was calculated as the weighted mean of their relative probabilities of being classified into each older age status, based on model ages ranging from 26 to 75. DAnHI in our large study population showed a steady increase with the increase in age and was positively associated with death after adjusting for chronological age. However, the effect size of DAnHI on the risk of death varied according to the age group and sex. The hazard ratio was highest in the 50-59-year age group and then decreased as the individuals aged. This study demonstrates that routine health check-up biomarkers can be integrated into a quantitative measure for predicting aging-related health status and death via appropriate statistical models and methodology. Our DAnHI-based results suggest that the same level of aging-related health status does not indicate the same degree of risk for death.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 10443144 Korea Health Industry Development Institute
فهرسة مساهمة: Keywords: Biological Aging; Differential Aging and Health Index; Mortality Prediction; Sex-Specific Aging
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240201 Date Completed: 20240415 Latest Revision: 20240722
رمز التحديث: 20240723
مُعرف محوري في PubMed: PMC11009216
DOI: 10.1007/s11357-024-01079-2
PMID: 38302843
قاعدة البيانات: MEDLINE
الوصف
تدمد:2509-2723
DOI:10.1007/s11357-024-01079-2