دورية أكاديمية
Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway.
| العنوان: | Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway. |
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| المؤلفون: | Tan Z; Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Boyapati K; Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Tressler CM; Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Jenkinson NM; Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Glunde K; Russell H. Morgan Department of Radiology and Radiological Science, Division of Cancer Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: kglunde@mri.jhu.edu. |
| المصدر: | Cancer letters [Cancer Lett] 2024 Apr 01; Vol. 586, pp. 216653. Date of Electronic Publication: 2024 Feb 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | beta Catenin*/metabolism , Triple Negative Breast Neoplasms*/pathology, Female ; Humans ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Epithelial-Mesenchymal Transition ; Glutamine ; Glycogen Synthase Kinase 3 beta/metabolism ; Wnt Signaling Pathway |
| مستخلص: | Breast cancer is the leading cancer-related cause of death in women. Here we show that solute carrier family 38-member 3 (SLC38A3) is overexpressed in breast cancer, particularly in triple-negative breast cancer (TNBC) cells and tissues. Our study reveals that SLC38A3 regulates cellular glutamine, glutamate, asparagine, aspartate, alanine, and glutathione (GSH) levels in breast cancer cells. Our data demonstrate that SLC38A3 enhances cell viability, cell migration and invasion in vitro, and promotes tumor growth and metastasis in vivo, while reducing apoptosis and oxidative stress. Mechanistically, we show that SLC38A3 suppresses the activity of glycogen synthase kinase 3-β (Gsk3β), a negative regulator of β-catenin, and increases protein levels of β-catenin, leading to the upregulation of epithelial-to-mesenchymal-transition (EMT)-inducing transcription factors and EMT markers in breast cancer. In summary, we show that SLC38A3 is overexpressed in breast cancer and promotes breast cancer metastasis via the GSK3β/β-catenin/EMT pathway, presenting a novel therapeutic target to explore for breast cancer. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | R01 CA213428 United States CA NCI NIH HHS; R01 CA213492 United States CA NCI NIH HHS; R01 CA264901 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Breast cancer; EMT; Glutamine; Metabolism; Metastasis; SLC38A3 |
| المشرفين على المادة: | 0 (beta Catenin) 0RH81L854J (Glutamine) EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta) EC 2.7.11.1 (GSK3B protein, human) 0 (SLC38A3 protein, human) |
| تواريخ الأحداث: | Date Created: 20240203 Date Completed: 20240312 Latest Revision: 20240428 |
| رمز التحديث: | 20240428 |
| DOI: | 10.1016/j.canlet.2024.216653 |
| PMID: | 38309615 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7980 |
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| DOI: | 10.1016/j.canlet.2024.216653 |