دورية أكاديمية
Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials.
| العنوان: | Monacolin K supplementation in patients with hypercholesterolemia: A systematic review of clinical trials. |
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| المؤلفون: | Liasi E; Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus., Kantilafti M; Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus., Hadjimbei E; Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus., Chrysostomou S; Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus. Electronic address: s.chrysostomou@euc.ac.cy. |
| المصدر: | Semergen [Semergen] 2024 May-Jun; Vol. 50 (4), pp. 102156. Date of Electronic Publication: 2024 Feb 03. |
| نوع المنشور: | Systematic Review; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saned, S.A Country of Publication: Spain NLM ID: 9610769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1578-8865 (Electronic) Linking ISSN: 11383593 NLM ISO Abbreviation: Semergen Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Madrid : Elsever España, : Saned, S.A. Original Publication: Madrid : Saned, S.A., [1996- |
| مواضيع طبية MeSH: | Hypercholesterolemia*/drug therapy , Dietary Supplements* , Randomized Controlled Trials as Topic* , Lovastatin*/administration & dosage , Lovastatin*/adverse effects , Anticholesteremic Agents*/administration & dosage , Anticholesteremic Agents*/adverse effects , Cholesterol, LDL*/blood , Biological Products* , Dicarboxylic Acids* , Fatty Acids*, Humans ; Dose-Response Relationship, Drug ; Cholesterol/blood |
| مستخلص: | Monacolin K is the major active component in red yeast rice (RYR) which is structurally identical to lovastatin and has the most powerful effect, in terms of reducing blood cholesterol levels. This review aimed to examine the effect and safety of different doses of monacolin K on blood cholesterol levels. PubMed and Cochrane were searched for articles published between 2012 and 2023 for clinical-trials and randomized-controlled-trials. Eligible studies included participants>18-years-old, of any gender and ethnicity. The intervention/exposure of interest was monacolin K. Hypercholesterolemia was considered the outcome of interest defined as the elevated total or low-density-lipoprotein (LDL) cholesterol levels. 12 randomized-controlled-trials were eligible for inclusion in the analysis including 769 participants>18-years-old. 11 out of 12 studies were assessed with high methodological quality and one study with low methodological quality. Monacolin K supplementation varied between 2mg and 10mg per day and the maximum period of supplementation was 12 weeks. All studies indicated a beneficial effect of monacolin supplementation on LDL and total cholesterol levels (p<0.05) regardless the dose and period of supplementation. Also, 3 of the included studies reported adverse side effects after treatment with monacolin K. Low doses of monacolin K equal to 3mg/day exert potential cholesterol-lowering effects although the number of relative studies is limited. Regarding the safety of monacolin K supplementation, findings seem to be more controversial and therefore, it is suggested for all patients treated with monacolin K to be routinely monitored regardless the dose of supplementation. (Copyright © 2023 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Arroz de levadura roja; Hipercolesterolemia; Hypercholesterolemia; Monacolin K; Monacolina K; Red yeast rice; Suplementación; Supplementation |
| المشرفين على المادة: | 9LHU78OQFD (Lovastatin) 0 (Anticholesteremic Agents) 0 (Cholesterol, LDL) 97C5T2UQ7J (Cholesterol) 0 (red yeast rice) 1EJ6Z6Q368 (8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) 0 (Biological Products) 0 (Dicarboxylic Acids) 0 (Fatty Acids) |
| تواريخ الأحداث: | Date Created: 20240204 Date Completed: 20240501 Latest Revision: 20240612 |
| رمز التحديث: | 20240613 |
| DOI: | 10.1016/j.semerg.2023.102156 |
| PMID: | 38310834 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1578-8865 |
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| DOI: | 10.1016/j.semerg.2023.102156 |