دورية أكاديمية
HPA flexibility and FKBP5 : promising physiological targets for conservation.
| العنوان: | HPA flexibility and FKBP5 : promising physiological targets for conservation. |
|---|---|
| المؤلفون: | Zimmer C; Laboratoire d'Ethologie Expérimentale et Comparée, LEEC, Université Sorbonne Paris Nord, UR 4443, 93430 Villetaneuse, France., Jimeno B; Instituto Pirenaico de Ecologia (IPE), CSIC, Avenida Nuestra Señora de la Victoria, 16, 22700 Jaca, Spain., Martin LB; Center for Global Health and Infectious Disease Research and Center for Genomics, University of South Florida, Tampa, FL 33612, USA. |
| المصدر: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2024 Mar 25; Vol. 379 (1898), pp. 20220512. Date of Electronic Publication: 2024 Feb 05. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society Country of Publication: England NLM ID: 7503623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2970 (Electronic) Linking ISSN: 09628436 NLM ISO Abbreviation: Philos Trans R Soc Lond B Biol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Royal Society, 1934- |
| مواضيع طبية MeSH: | Hypothalamo-Hypophyseal System*/physiology , Pituitary-Adrenal System*/physiology , Tacrolimus Binding Proteins*/physiology, Humans ; Brain/physiology ; Glucocorticoids/metabolism |
| مستخلص: | Hypothalamic-pituitary-adrenal axis (HPA) flexibility is an emerging concept recognizing that individuals that will cope best with stressors will probably be those using their hormones in the most adaptive way. The HPA flexibility concept considers glucocorticoids as molecules that convey information about the environment from the brain to the body so that the organismal phenotype comes to complement prevailing conditions. In this context, FKBP5 protein appears to set the extent to which circulating glucocorticoid concentrations can vary within and across stressors. Thus, FKBP5 expression, and the HPA flexibility it causes, seem to represent an individual's ability to regulate its hormones to orchestrate organismal responses to stressors. As FKBP5 expression can also be easily measured in blood, it could be a worthy target of conservation-oriented research attention. We first review the known and likely roles of HPA flexibility and FKBP5 in wildlife. We then describe putative genetic, environmental and epigenetic causes of variation in HPA flexibility and FKBP5 expression among and within individuals. Finally, we hypothesize how HPA flexibility and FKBP5 expression should affect organismal fitness and hence population viability in response to human-induced rapid environmental changes, particularly urbanization. This article is part of the theme issue 'Endocrine responses to environmental variation: conceptual approaches and recent developments'. |
| References: | Endocr Rev. 2000 Feb;21(1):55-89. (PMID: 10696570) Proc Biol Sci. 2016 Nov 30;283(1843):. (PMID: 27881753) Trends Ecol Evol. 2020 Nov;35(11):981-989. (PMID: 32723498) Mol Psychiatry. 2009 Mar;14(3):261-8. (PMID: 18180755) Biol Psychiatry. 2011 Nov 15;70(10):928-36. (PMID: 21907973) Neuropharmacology. 2012 Jan;62(1):3-12. (PMID: 21807003) Horm Behav. 2006 Mar;49(3):369-75. (PMID: 16257404) PLoS One. 2014 Nov 11;9(11):e110564. (PMID: 25386675) J Neuroendocrinol. 2001 May;13(5):412-20. (PMID: 11328450) Elife. 2022 Feb 11;11:. (PMID: 35144728) Integr Comp Biol. 2017 Aug 1;57(2):385-395. (PMID: 28859411) Horm Behav. 2012 May;61(5):763-72. (PMID: 22507448) Proc Biol Sci. 2017 Jul 26;284(1859):. (PMID: 28724737) Am Nat. 1992 Nov;140 Suppl 1:S33-62. (PMID: 19426026) Proc Biol Sci. 2022 Feb 9;289(1968):20211633. (PMID: 35135348) J Exp Biol. 2021 Jun 15;224(12):. (PMID: 34142697) Biol Psychiatry. 2018 May 15;83(10):821-830. (PMID: 29573791) JAMA. 2008 Mar 19;299(11):1291-305. (PMID: 18349090) Proc Biol Sci. 2020 Oct 14;287(1936):20201754. (PMID: 33023414) Conserv Physiol. 2013 Mar 13;1(1):cot001. (PMID: 27293585) Behav Brain Res. 1993 Nov 30;57(2):175-82. (PMID: 8117422) Gen Comp Endocrinol. 2021 Sep 1;310:113809. (PMID: 33964287) Int J Mol Sci. 2019 Jun 04;20(11):. (PMID: 31167373) Trends Mol Med. 2007 Jul;13(7):269-77. (PMID: 17544850) Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13699-704. (PMID: 26483456) Conserv Physiol. 2021 Jul 02;9(1):coab050. (PMID: 34249365) Gen Comp Endocrinol. 2021 Jan 1;300:113611. (PMID: 32950580) Bioessays. 2016 Sep;38(9):894-902. (PMID: 27374865) Sci Rep. 2019 Nov 1;9(1):15869. (PMID: 31676805) Trends Ecol Evol. 2020 Feb;35(2):115-124. (PMID: 31706627) Sci Rep. 2021 Sep 21;11(1):18758. (PMID: 34548535) PLoS One. 2011 Feb 09;6(2):e16883. (PMID: 21347384) Mol Psychiatry. 2021 Jul;26(7):3060-3076. (PMID: 33649453) Horm Behav. 2022 Sep;145:105240. (PMID: 35933849) Proc Biol Sci. 2012 Feb 22;279(1729):759-66. (PMID: 21775332) Gen Comp Endocrinol. 2006 Oct;149(1):1-9. (PMID: 16750533) Biol Lett. 2015 Jul;11(7):. (PMID: 26179799) Epigenomics. 2013 Apr;5(2):109-12. (PMID: 23566086) Proc Biol Sci. 2009 Jun 7;276(1664):2051-6. (PMID: 19324794) BMC Psychiatry. 2013 Aug 15;13:213. (PMID: 23945090) Sci Data. 2018 May 22;5:180097. (PMID: 29786693) Horm Behav. 2017 Aug;94:1-12. (PMID: 28622973) J Exp Zool A Ecol Integr Physiol. 2020 Dec;333(10):779-791. (PMID: 32488987) J Exp Biol. 2022 Mar 8;225(Suppl_1):. (PMID: 35258612) J Exp Biol. 2022 Aug 15;225(16):. (PMID: 36017760) Trends Ecol Evol. 2012 Aug;27(8):428-35. (PMID: 22613457) Sci Total Environ. 2020 Jun 15;721:137332. (PMID: 32169634) Trends Ecol Evol. 2022 Feb;37(2):129-137. (PMID: 34635340) Eur J Endocrinol. 1994 Nov;131(5):443-50. (PMID: 7952154) Gen Comp Endocrinol. 2014 Sep 15;206:227-34. (PMID: 25125084) Gen Comp Endocrinol. 2007 May 1;151(3):342-50. (PMID: 17368638) Gen Comp Endocrinol. 2023 Feb 1;332:114159. (PMID: 36368439) Gen Comp Endocrinol. 2013 Mar 1;183:32-7. (PMID: 23262276) Biol Lett. 2020 Jan;16(1):20190733. (PMID: 31937214) Trends Endocrinol Metab. 2019 Nov;30(11):807-818. (PMID: 31699238) Trends Ecol Evol. 2016 Jun;31(6):476-488. (PMID: 27055729) Neuropsychopharmacology. 2016 Jan;41(1):261-74. (PMID: 26250598) J Exp Zool A Ecol Integr Physiol. 2022 Jan;337(1):7-14. (PMID: 33819389) J Neuroendocrinol. 2020 May;32(5):e12852. (PMID: 32364267) Horm Behav. 2021 Sep;135:105038. (PMID: 34280702) Psychiatry Res. 2017 Sep;255:72-77. (PMID: 28528244) Integr Comp Biol. 2018 Oct 1;58(4):800-813. (PMID: 30052988) Nat Neurosci. 2013 Jan;16(1):33-41. (PMID: 23201972) Biol Psychiatry. 1991 Nov 15;30(10):1008-16. (PMID: 1756195) Biol Lett. 2015 Aug;11(8):. (PMID: 26311159) Sci Rep. 2020 Aug 13;10(1):13682. (PMID: 32792550) Gen Comp Endocrinol. 2008 Jul;157(3):288-95. (PMID: 18602555) Life Sci. 2003 Aug 22;73(14):1835-45. (PMID: 12888122) Trends Ecol Evol. 2021 Jan;36(1):39-48. (PMID: 33032863) Clin Endocrinol (Oxf). 2004 Sep;61(3):327-31. (PMID: 15355448) Integr Comp Biol. 2009 Oct;49(4):365-79. (PMID: 21665827) Mol Cell Endocrinol. 2023 Apr 5;565:111886. (PMID: 36775244) Ann N Y Acad Sci. 2010 May;1195:129-48. (PMID: 20536821) Horm Behav. 2023 Apr;150:105311. (PMID: 36707334) J Anim Ecol. 2023 Jun;92(6):1149-1160. (PMID: 36815243) Trends Ecol Evol. 2010 Feb;25(2):81-9. (PMID: 19748700) Clin Epigenetics. 2019 May 23;11(1):83. (PMID: 31122292) Integr Comp Biol. 2011 Oct;51(4):514-27. (PMID: 21705794) Mol Cell Endocrinol. 2020 Nov 1;517:110983. (PMID: 32781249) Biol Lett. 2013 Apr 10;9(3):20130181. (PMID: 23576781) Proc Biol Sci. 2006 Sep 7;273(1598):2227-31. (PMID: 16901843) Genes Brain Behav. 2014 Jan;13(1):25-37. (PMID: 24219237) J Anim Ecol. 2008 May;77(3):478-86. (PMID: 18312336) Neurobiol Stress. 2017 Aug 22;7:113-121. (PMID: 28879214) Nat Genet. 2003 Mar;33 Suppl:245-54. (PMID: 12610534) Nat Neurosci. 2004 Aug;7(8):847-54. (PMID: 15220929) J Mil Veteran Fam Health. 2019 Sep;5(2):88-99. (PMID: 34307838) Horm Behav. 2018 Jan;97:31-38. (PMID: 29030109) J Evol Biol. 2007 May;20(3):831-44. (PMID: 17465894) Integr Comp Biol. 2022 Aug 13;62(1):58-70. (PMID: 34665256) Trends Endocrinol Metab. 2022 Jan;33(1):8-17. (PMID: 34750063) Evolution. 2022 Mar;76(3):394-413. (PMID: 34962651) Am J Psychiatry. 2014 Aug;171(8):872-880. (PMID: 24832930) J Trauma Stress. 2009 Oct;22(5):427-34. (PMID: 19813242) Horm Behav. 2010 Feb;57(2):105-11. (PMID: 19786032) J Anim Ecol. 2023 Feb;92(2):403-416. (PMID: 36477754) Proc Biol Sci. 2013 Aug 14;280(1768):20131444. (PMID: 23945686) Trends Ecol Evol. 2019 Apr;34(4):303-314. (PMID: 30704782) Horm Behav. 2023 Mar;149:105316. (PMID: 36731260) Neuropsychopharmacology. 2012 May;37(6):1455-64. (PMID: 22237309) Philos Trans R Soc Lond B Biol Sci. 2024 Mar 25;379(1898):20220502. (PMID: 38310929) Proc Biol Sci. 2016 Aug 17;283(1836):. (PMID: 27512147) Proc Biol Sci. 2022 Nov 30;289(1987):20221600. (PMID: 36448281) Sci Rep. 2017 Apr 07;7:46125. (PMID: 28387355) Trends Ecol Evol. 2006 Apr;21(4):186-91. (PMID: 16701084) Gen Comp Endocrinol. 2002 Aug;128(1):1-24. (PMID: 12270784) J Neuroendocrinol. 2014 Dec;26(12):853-60. (PMID: 25303060) J Clin Invest. 2013 Oct;123(10):4158-69. (PMID: 23999428) J Clin Endocrinol Metab. 2002 Nov;87(11):4984-90. (PMID: 12414862) Proc Biol Sci. 2012 Nov 7;279(1746):4375-81. (PMID: 22951742) Nat Neurosci. 1998 May;1(1):69-73. (PMID: 10195112) Integr Comp Biol. 2021 Oct 4;61(3):1147-1159. (PMID: 34021748) Philos Trans R Soc Lond B Biol Sci. 2008 May 12;363(1497):1611-20. (PMID: 18048296) Philos Trans R Soc Lond B Biol Sci. 2010 Dec 27;365(1560):4065-76. (PMID: 21078658) Am Nat. 2010 Jun;175(6):687-701. (PMID: 20394524) Proc Biol Sci. 2022 Nov 09;289(1986):20221235. (PMID: 36350212) Gen Comp Endocrinol. 2018 Dec 1;269:177-183. (PMID: 30257180) Mol Cell Endocrinol. 2022 Oct 1;556:111737. (PMID: 35931299) Conserv Physiol. 2020 Jan 27;8(1):coz110. (PMID: 31993201) Am Nat. 2022 Nov;200(5):662-674. (PMID: 36260844) Trends Ecol Evol. 2009 Nov;24(11):634-42. (PMID: 19679371) Gen Comp Endocrinol. 2017 Sep 1;250:15-20. (PMID: 28559207) Mol Ecol. 2023 Jul;32(14):3960-3974. (PMID: 37154074) |
| فهرسة مساهمة: | Keywords: coping; corticosterone; hormone; stress; urbanization; wildlife |
| المشرفين على المادة: | 0 (Glucocorticoids) EC 5.2.1.8 (tacrolimus binding protein 5) EC 5.2.1.- (Tacrolimus Binding Proteins) |
| تواريخ الأحداث: | Date Created: 20240204 Date Completed: 20240206 Latest Revision: 20240306 |
| رمز التحديث: | 20240307 |
| مُعرف محوري في PubMed: | PMC10838639 |
| DOI: | 10.1098/rstb.2022.0512 |
| PMID: | 38310934 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1471-2970 |
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| DOI: | 10.1098/rstb.2022.0512 |