دورية أكاديمية

Challenges and advances in the medical treatment of granulomatous amebic encephalitis.

التفاصيل البيبلوغرافية
العنوان: Challenges and advances in the medical treatment of granulomatous amebic encephalitis.
المؤلفون: Spottiswoode N; Division of Infectious Diseases, University of California San Francisco, San Francisco, CA, USA., Haston JC; Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Hanners NW; Division of Pediatric Infectious Diseases, University of Texas Southwestern, Dallas, TX, USA., Gruenberg K; Department of Clinical Pharmacy, University of California San Francisco School of Pharmacy, San Francisco, CA, USA., Kim A; Department of Clinical Pharmacy, Zuckerberg San Francisco General, San Francisco, CA, USA., DeRisi JL; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.; Chan Zuckerberg Biohub SF, San Francisco, CA, USA., Wilson MR; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
المصدر: Therapeutic advances in infectious disease [Ther Adv Infect Dis] 2024 Feb 02; Vol. 11, pp. 20499361241228340. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101606715 Publication Model: eCollection Cited Medium: Print ISSN: 2049-9361 (Print) Linking ISSN: 20499361 NLM ISO Abbreviation: Ther Adv Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : SAGE Publications, [2013]-
مستخلص: Granulomatous amebic encephalitis, caused by the free-living amebae Balamuthia mandrillaris or Acanthamoeba species, is a rare and deadly infectious syndrome with a current mortality rate of >90%. Much work remains to define the optimal treatment for these infections. Here, we provide a comprehensive overview of the supporting evidence behind antimicrobials currently recommended by the Centers for Disease Control and Prevention (CDC) with updated statistics on survival rates and medication usage from the CDC Free-Living Ameba Database. We also discuss promising treatments, especially the emerging therapeutic agent nitroxoline, and provide recommendations for the next steps in this area.
Competing Interests: The authors declare that there is no conflict of interest.
(© The Author(s), 2024.)
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معلومات مُعتمدة: T32 AI007641 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Acanthamoeba; Balamuthia; ameba; drug repurposing; encephalitis
تواريخ الأحداث: Date Created: 20240205 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10838035
DOI: 10.1177/20499361241228340
PMID: 38312848
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9361
DOI:10.1177/20499361241228340