دورية أكاديمية
أعرض في EDS

Comparison of Gambier Extract (Uncaria Gambier Robx) and Angiotensin Receptor Blocker on Proteinuria Reduction and Antioxidants - Enhancement in Nephrotic Rat Models.

التفاصيل البيبلوغرافية
العنوان: Comparison of Gambier Extract (Uncaria Gambier Robx) and Angiotensin Receptor Blocker on Proteinuria Reduction and Antioxidants - Enhancement in Nephrotic Rat Models.
المؤلفون: Siregar RS; Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.; Department of Pediatric, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Ramayani OR; Department of Pediatric, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Haris D; Department of Anatomy Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Lelo A; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Jusuf NK; Department of Dermatology & Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Eyanoer PC; Department of Community and Preventive Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Rusda M; Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia., Amin MM; Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.; Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
المصدر: Medical archives (Sarajevo, Bosnia and Herzegovina) [Med Arch] 2023; Vol. 77 (6), pp. 422-427.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Academy of Medical Sciences of Bosnia and Herzegovina Country of Publication: Bosnia and Herzegovina NLM ID: 101635337 Publication Model: Print Cited Medium: Internet ISSN: 1986-5961 (Electronic) Linking ISSN: 0350199X NLM ISO Abbreviation: Med Arch Subsets: MEDLINE
أسماء مطبوعة: Publication: Sarajevo, Bosnia and Herzegovina : Academy of Medical Sciences of Bosnia and Herzegovina
Original Publication: Sarajevo, Bosnia and Herzegovina : Avicena, 2012-
مواضيع طبية MeSH: Antioxidants*/pharmacology , Antioxidants*/therapeutic use , Nephrotic Syndrome* , Plant Extracts* , Cat's Claw*, Male ; Rats ; Animals ; Losartan/pharmacology ; Losartan/therapeutic use ; Rats, Wistar ; Angiotensin Receptor Antagonists/adverse effects ; Angiotensin-Converting Enzyme Inhibitors/adverse effects ; Proteinuria/drug therapy ; Superoxide Dismutase/adverse effects ; Superoxide Dismutase/metabolism
مستخلص: Background: Proteinuria is a significant clinical manifestation that causes edema in several diseases, including Nephrotic Syndrome (NS). Untreated proteinuria is strongly linked to the progression of kidney failure. One of the adjuvant therapies could be used to reduce proteinuria such as Angiotensin Receptor Blocker (ARB) including Losartan®. Gambier is a traditional medicinal plant widely known for its antioxidant effects. Catechin, a compound contained in Gambier Extract (GE), has been used to reduce microalbuminuria in diabetics. However, its application in NS has not been widely studied.
Objective: This study compared the effects of GE and ARB in reducing proteinuria and increasing antioxidant activity levels, as well as reported histopathological findings in the nephrotic Wistar rat model.
Methods: An experimental design study with a control group and a posttest was conducted. The experimental animals were divided into four groups: the control group (K1), the group with puromycin aminonucleoside (PAN) injection (K2), the group with PAN injection + GE (K3), and the group with PAN injection + Losartan® (K4). The standard GE used was Sarie Uncariae® by Toyo Brothers, PT while the ARB (Losartan®) was obtained from Novell, PT. Protein urine, the activity level of total superoxide dismutase (T-SOD), and malondialdehyde (MDA) were assessed using the colorimetric method. Renal histopathology was assessed based on Rollerman's criteria.
Results: Gambier extract significantly reduced proteinuria, as depicted by a decrease in protein/volume urine (p = 0.009), increased antioxidant activity, as illustrated by an elevation in T-SOD activity levels (p = 0.007), and tended to decrease MDA levels compared to Losartan®. Based on histopathological findings, GE tended to reduce the percentage of kidney damage in rats induced by puromycin.
Conclusion: Gambier extract has been shown a higher antioxidant effect by increasing T-SOD activity levels, reducing proteinuria and also exhibiting a tendency to diminish kidney damage.
Competing Interests: Authors declare that there are no potential conflicts of interest.
(© 2023 Rosmayanti S Siregar, Oke Rina Ramayani, Delyuzar Haris, Aznan Lelo, Nelva Karmila Jusuf, Putri Chairani Eyanoer, Muhammad Rusda, Mustafa Mahmud Amin.)
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فهرسة مساهمة: Keywords: Gambier; Losartan®; MDA; Proteinuria; SOD
المشرفين على المادة: 0 (Antioxidants)
JMS50MPO89 (Losartan)
9060PRM18Q (cat's claw extract)
0 (Angiotensin Receptor Antagonists)
0 (Angiotensin-Converting Enzyme Inhibitors)
EC 1.15.1.1 (Superoxide Dismutase)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20240205 Date Completed: 20240206 Latest Revision: 20240206
رمز التحديث: 20240206
مُعرف محوري في PubMed: PMC10834053
DOI: 10.5455/medarh.2023.77.422-427
PMID: 38313113
قاعدة البيانات: MEDLINE
الوصف
تدمد:1986-5961
DOI:10.5455/medarh.2023.77.422-427