دورية أكاديمية
Cholecystokinin and cholecystokinin-A receptor: An attractive treatment strategy for biliary dyskinesia?
| العنوان: | Cholecystokinin and cholecystokinin-A receptor: An attractive treatment strategy for biliary dyskinesia? |
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| المؤلفون: | Chang J; Tianjin Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China., Liu Y; Department of Gastroenterology, Tianjin Hospital of Integrated Traditional Chinese and Western Medicine Nankai Hospital, Tianjin 300100, China., Jiang TC; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China., Zhao L; Tianjin Institute of Acupuncture and Moxibustion, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China. lanzhao69@163.com., Liu JW; School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. |
| المصدر: | World journal of gastroenterology [World J Gastroenterol] 2024 Jan 21; Vol. 30 (3), pp. 283-285. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing : WJG Press, c1998- |
| مواضيع طبية MeSH: | Cholecystokinin* , Biliary Dyskinesia*/drug therapy, Animals ; Guinea Pigs ; Receptor, Cholecystokinin A ; Common Bile Duct ; Receptors, Cholecystokinin |
| مستخلص: | Biliary dyskinesia is a relatively common gastrointestinal disease that is increasing in incidence as living standards improve. However, its underlying pathogenesis remains unclear, hindering the development of therapeutic drugs. Recently, "Expression and functional study of cholecystokinin-A receptors on the interstitial Cajal-like cells of the guinea pig common bile duct" demonstrated that cholecystokinin (CCK) regulates the contractile function of the common bile duct through interaction with the CCK-A receptor in interstitial Cajal-like cells, contributing to improving the academic understanding of biliary tract dynamics and providing emerging directions for the pathogenesis and clinical management of biliary dyskinesia. This letter provides a brief overview of the role of CCK and CCK-A receptors in biliary dyskinesia from the perspective of animal experiments and clinical studies, and discusses prospects and challenges for the clinical application of CCK and CCK-A receptors as potential therapeutic targets. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Biliary dyskinesia; Cholecystokinin; Cholecystokinin-A receptor; Interstitial Cajal-like cell; Therapeutic target |
| المشرفين على المادة: | 9011-97-6 (Cholecystokinin) 0 (Receptor, Cholecystokinin A) 0 (Receptors, Cholecystokinin) |
| تواريخ الأحداث: | Date Created: 20240205 Date Completed: 20240206 Latest Revision: 20240206 |
| رمز التحديث: | 20240206 |
| مُعرف محوري في PubMed: | PMC10835532 |
| DOI: | 10.3748/wjg.v30.i3.283 |
| PMID: | 38314130 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2219-2840 |
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| DOI: | 10.3748/wjg.v30.i3.283 |