دورية أكاديمية
أعرض في EDS

LRP10 and α-synuclein transmission in Lewy body diseases.

التفاصيل البيبلوغرافية
العنوان: LRP10 and α-synuclein transmission in Lewy body diseases.
المؤلفون: Carreras Mascaro A; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Grochowska MM; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Boumeester V; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Dits NFJ; Department of Urology, Erasmus Medical Center, Rotterdam, The Netherlands., Bilgiҫ EN; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Breedveld GJ; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Vergouw L; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., de Jong FJ; Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands., van Royen ME; Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands., Bonifati V; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands., Mandemakers W; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. w.mandemakers@erasmusmc.nl.
المصدر: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Feb 05; Vol. 81 (1), pp. 75. Date of Electronic Publication: 2024 Feb 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Basel : Springer
Original Publication: Basel ; Boston : Birkhauser, c1997-
مواضيع طبية MeSH: Parkinson Disease*/pathology , Lewy Body Disease*/genetics , Lewy Body Disease*/metabolism , Lewy Body Disease*/pathology, Humans ; alpha-Synuclein/metabolism ; Lewy Bodies/metabolism ; Brain/metabolism ; LDL-Receptor Related Proteins/metabolism
مستخلص: Autosomal dominant variants in LRP10 have been identified in patients with Lewy body diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease-dementia (PDD), and dementia with Lewy bodies (DLB). Nevertheless, there is little mechanistic insight into the role of LRP10 in disease pathogenesis. In the brains of control individuals, LRP10 is typically expressed in non-neuronal cells like astrocytes and neurovasculature, but in idiopathic and genetic cases of PD, PDD, and DLB, it is also present in α-synuclein-positive neuronal Lewy bodies. These observations raise the questions of what leads to the accumulation of LRP10 in Lewy bodies and whether a possible interaction between LRP10 and α-synuclein plays a role in disease pathogenesis. Here, we demonstrate that wild-type LRP10 is secreted via extracellular vesicles (EVs) and can be internalised via clathrin-dependent endocytosis. Additionally, we show that LRP10 secretion is highly sensitive to autophagy inhibition, which induces the formation of atypical LRP10 vesicular structures in neurons in human-induced pluripotent stem cells (iPSC)-derived brain organoids. Furthermore, we show that LRP10 overexpression leads to a strong induction of monomeric α-synuclein secretion, together with time-dependent, stress-sensitive changes in intracellular α-synuclein levels. Interestingly, patient-derived astrocytes carrying the c.1424 + 5G > A LRP10 variant secrete aberrant high-molecular-weight species of LRP10 in EV-free media fractions. Finally, we show that this truncated patient-derived LRP10 protein species (LRP10 splice ) binds to wild-type LRP10, reduces LRP10 wild-type levels, and antagonises the effect of LRP10 on α-synuclein levels and distribution. Together, this work provides initial evidence for a possible functional role of LRP10 in LBDs by modulating intra- and extracellular α-synuclein levels, and pathogenic mechanisms linked to the disease-associated c.1424 + 5G > A LRP10 variant, pointing towards potentially important disease mechanisms in LBDs.
(© 2024. The Author(s).)
References: Lancet Neurol. 2018 Jan;17(1):64-74. (PMID: 29263008)
J Neuropathol Exp Neurol. 2009 Oct;68(10):1073-83. (PMID: 19918119)
J Biol Chem. 2003 Apr 4;278(14):11753-9. (PMID: 12551928)
Acta Neuropathol. 2010 Jan;119(1):7-35. (PMID: 20012068)
Mol Neurodegener. 2012 Aug 24;7:42. (PMID: 22920859)
Nat Cell Biol. 2016 Jul;18(7):765-76. (PMID: 27295555)
Exp Neurol. 2008 Jan;209(1):5-11. (PMID: 17603039)
Neurobiol Dis. 2011 Jun;42(3):360-7. (PMID: 21303699)
EMBO J. 2017 May 15;36(10):1392-1411. (PMID: 28331029)
Dev Cell. 2006 Jun;10(6):839-50. (PMID: 16740485)
Mov Disord. 2020 May;35(5):760-773. (PMID: 32034799)
Brain. 2020 Jul 1;143(7):2220-2234. (PMID: 32613234)
Science. 2003 Oct 31;302(5646):841. (PMID: 14593171)
Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):. (PMID: 28108534)
Autophagy. 2018;14(1):98-119. (PMID: 29198173)
Semin Pediatr Neurol. 2013 Dec;20(4):230-5. (PMID: 24365570)
Acta Neuropathol Commun. 2019 Sep 2;7(1):142. (PMID: 31477175)
Biochemistry. 2000 Dec 26;39(51):15817-25. (PMID: 11123907)
FASEB J. 2006 Mar;20(3):419-25. (PMID: 16507759)
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19573-8. (PMID: 20974939)
Nature. 2017 Jan 26;541(7638):481-487. (PMID: 28099414)
Cell. 2011 Jul 8;146(1):37-52. (PMID: 21700325)
J Virol. 2017 Jan 3;91(2):. (PMID: 27852849)
JAMA Neurol. 2013 Jun;70(6):727-35. (PMID: 23588557)
Lancet Neurol. 2018 Jul;17(7):597-608. (PMID: 29887161)
Int J Geriatr Psychiatry. 2020 May;35(5):436-448. (PMID: 31898332)
Cell Stem Cell. 2016 Apr 7;18(4):541-53. (PMID: 26971820)
Elife. 2020 Nov 03;9:. (PMID: 33138918)
Nat Rev Neurol. 2020 Apr;16(4):199-212. (PMID: 32203399)
Neuropathol Appl Neurobiol. 2019 Apr;45(3):262-277. (PMID: 29797340)
Nat Rev Neurosci. 2017 Sep;18(9):515-529. (PMID: 28747776)
BMC Neurosci. 2015 Sep 07;16:57. (PMID: 26346361)
Acta Neuropathol. 2000 Mar;99(3):296-304. (PMID: 10663973)
Acta Neuropathol. 2021 Feb;141(2):159-172. (PMID: 33399945)
Acta Neuropathol Commun. 2022 Nov 12;10(1):163. (PMID: 36371251)
Cell Stem Cell. 2015 Jun 4;16(6):591-600. (PMID: 26046759)
J Neurosci. 2011 May 18;31(20):7264-74. (PMID: 21593311)
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S1-6. (PMID: 26350119)
Protein Pept Lett. 2011 Mar;18(3):230-40. (PMID: 20858207)
Front Mol Neurosci. 2017 Mar 01;10:54. (PMID: 28298885)
Am J Pathol. 2023 May;193(5):520-531. (PMID: 36773784)
Traffic. 2008 Sep;9(9):1551-62. (PMID: 18627575)
Nat Clin Pract Neurol. 2006 Dec;2(12):679-89. (PMID: 17117171)
Can J Neurol Sci. 2016 Apr;43 Suppl 1:S83-95. (PMID: 27307129)
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211. (PMID: 12498954)
Mol Neurodegener. 2022 Sep 2;17(1):57. (PMID: 36056345)
Mol Neurodegener. 2018 May 11;13(1):21. (PMID: 29751824)
PLoS Biol. 2007 Dec;5(12):e325. (PMID: 18076286)
Neuron. 1995 Feb;14(2):467-75. (PMID: 7857654)
J Neurochem. 2016 Oct;139(2):181-186. (PMID: 27454326)
Nat Cell Biol. 2013 May;15(5):461-71. (PMID: 23563491)
Cell. 2016 Oct 6;167(2):566-580.e19. (PMID: 27716510)
J Mol Biol. 2020 Apr 3;432(8):2651-2672. (PMID: 32061929)
Neuropathol Appl Neurobiol. 2001 Oct;27(5):362-72. (PMID: 11679088)
Mol Neurobiol. 2021 Mar;58(3):1212-1216. (PMID: 33118139)
Mol Brain. 2010 Apr 21;3:12. (PMID: 20409326)
Nat Rev Neurosci. 2006 Jan;7(1):41-53. (PMID: 16371949)
Stem Cell Reports. 2019 Feb 12;12(2):213-229. (PMID: 30639209)
PLoS One. 2011;6(8):e23939. (PMID: 21886844)
J Biol Chem. 2021 Jan-Jun;296:100715. (PMID: 33930462)
Science. 1980 Aug 15;209(4458):809-10. (PMID: 7403847)
Sci Adv. 2021 Jan 6;7(2):. (PMID: 33523961)
PLoS One. 2013;8(3):e59252. (PMID: 23533608)
Neurobiol Aging. 2020 Oct;94:311.e5-311.e10. (PMID: 32527607)
Neuron. 2016 Jan 6;89(1):37-53. (PMID: 26687838)
Science. 2010 Sep 24;329(5999):1663-7. (PMID: 20798282)
Mol Neurodegener. 2012 Jun 26;7:31. (PMID: 22734645)
Cell Death Dis. 2018 Jul 9;9(7):757. (PMID: 29988147)
J Biol Chem. 2004 Mar 26;279(13):12924-34. (PMID: 14711827)
Sci Rep. 2016 Jun 27;6:28823. (PMID: 27346864)
Neuron. 2020 Aug 5;107(3):436-453.e12. (PMID: 32485136)
Acta Neuropathol. 2003 Feb;105(2):163-9. (PMID: 12536227)
Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20051-6. (PMID: 19892735)
Cell Signal. 2014 May;26(5):1068-74. (PMID: 24412751)
Biomaterials. 2021 Apr;271:120700. (PMID: 33631652)
Trends Neurosci. 2017 Jun;40(6):358-370. (PMID: 28527591)
Parkinsonism Relat Disord. 2019 Aug;65:243-247. (PMID: 31147221)
J Neurosci. 2010 May 19;30(20):6838-51. (PMID: 20484626)
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10732-7. (PMID: 25002524)
J Neurosci. 2020 Jul 8;40(28):5347-5361. (PMID: 32457076)
Proteomics Clin Appl. 2015 Apr;9(3-4):358-67. (PMID: 25684126)
Histochem Cell Biol. 2008 Aug;130(2):315-27. (PMID: 18461348)
Nat Neurosci. 2023 Dec;26(12):2250. (PMID: 37814027)
Neurobiol Aging. 2021 Jan;97:145.e17-145.e22. (PMID: 32690342)
Nature. 2018 May;557(7706):558-563. (PMID: 29743672)
Acta Neuropathol. 2000 Jan;99(1):14-20. (PMID: 10651022)
Neurobiol Dis. 2014 Sep;69:76-92. (PMID: 24878508)
J Extracell Vesicles. 2018 Nov 23;7(1):1535750. (PMID: 30637094)
Mov Disord. 2019 Jun;34(6):912-916. (PMID: 30964957)
Hum Mol Genet. 2015 Nov 1;24(21):6013-28. (PMID: 26251043)
J Virol. 2016 Sep 29;90(20):9182-93. (PMID: 27489279)
Stem Cell Reports. 2015 Feb 10;4(2):199-208. (PMID: 25640760)
Lancet Neurol. 2012 Nov;11(11):986-98. (PMID: 23079555)
Brain. 2023 May 2;146(5):1873-1887. (PMID: 36348503)
Brain. 2019 Sep 1;142(9):2828-2844. (PMID: 31324919)
Stem Cell Reports. 2017 May 9;8(5):1144-1154. (PMID: 28416282)
Brain. 2016 Feb;139(Pt 2):481-94. (PMID: 26647156)
Nat Genet. 2007 Feb;39(2):168-77. (PMID: 17220890)
Bio Protoc. 2022 Oct 05;12(19):. (PMID: 36313194)
Brain. 2004 Feb;127(Pt 2):420-30. (PMID: 14662519)
Cell Rep. 2021 Jun 8;35(10):109189. (PMID: 34107263)
N Engl J Med. 2004 Mar 25;350(13):1353-6. (PMID: 14999088)
J Neurosci. 2019 Nov 20;39(47):9269-9273. (PMID: 31748282)
J Neurochem. 2005 Aug;94(3):839-49. (PMID: 16033426)
Acta Neuropathol. 2014 Nov;128(5):639-650. (PMID: 24997849)
Glia. 2013 May;61(5):800-12. (PMID: 23440919)
Nature. 2020 Apr;580(7803):381-385. (PMID: 32296178)
Trends Neurosci. 1998 Jun;21(6):249-54. (PMID: 9641537)
J Alzheimers Dis. 2020;76(3):1161-1170. (PMID: 32597809)
J Mol Biol. 2023 Jun 15;435(12):168011. (PMID: 36792008)
Neurobiol Dis. 2017 Jul;103:101-112. (PMID: 28411117)
Transl Neurodegener. 2013 Oct 04;2(1):20. (PMID: 24093918)
J Neurochem. 2019 Sep;150(5):566-576. (PMID: 31265132)
Traffic. 2009 Aug;10(8):1098-114. (PMID: 19497050)
Acta Neuropathol. 2007 Sep;114(3):231-41. (PMID: 17576580)
Lancet Neurol. 2019 May;18(5):459-480. (PMID: 30879893)
Neuron. 2017 Nov 1;96(3):697-708. (PMID: 29096081)
Neuron. 2011 Oct 6;72(1):57-71. (PMID: 21982369)
Neurol Sci. 2023 Mar;44(3):905-912. (PMID: 36434476)
Neuron. 2021 Aug 4;109(15):2413-2426.e7. (PMID: 34157306)
J Neurol Neurosurg Psychiatry. 2000 May;68(5):605-8. (PMID: 10766891)
Acta Neuropathol. 2021 Jul;142(1):117-137. (PMID: 33913039)
Neurobiol Aging. 2021 Mar;99:99.e1-99.e6. (PMID: 32950273)
معلومات مُعتمدة: 110875 Stichting ParkinsonFonds; 110825 Stichting ParkinsonFonds; WE.03-2019-07 Alzheimer Nederland
فهرسة مساهمة: Keywords: Astrocytes; Brain organoids; Dementia with Lewy bodies (DLB); Extracellular vesicles (EVs); Induced pluripotent stem cells (iPSC); Lewy body diseases (LBDs); Low-density lipoprotein receptor-related protein 10 (LRP10); Parkinson’s disease (PD); α-Synuclein
المشرفين على المادة: 0 (alpha-Synuclein)
0 (LRP10 protein, human)
0 (LDL-Receptor Related Proteins)
تواريخ الأحداث: Date Created: 20240205 Date Completed: 20240207 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10844361
DOI: 10.1007/s00018-024-05135-0
PMID: 38315424
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-9071
DOI:10.1007/s00018-024-05135-0