دورية أكاديمية

Principles for management of hip fracture for older adults taking direct oral anticoagulants: an international consensus statement.

التفاصيل البيبلوغرافية
العنوان: Principles for management of hip fracture for older adults taking direct oral anticoagulants: an international consensus statement.
المؤلفون: Mitchell RJ; Australian Institute of Health Innovation, Macquarie University, Sydney, NSW, Australia., Wijekulasuriya S; Department of Anaesthesia, Huddersfield Royal Infirmary, Huddersfield, UK., Mayor A; Department of Medicine, McMaster University, Hamilton, ON, Canada., Borges FK; Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil., Tonelli AC; Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.; Department of Orthopaedic Surgery and Biomedical Engineering, University of Michigan, Ann Arbour, MI, USA., Ahn J; Department of Geriatric Medicine, Fiona Stanley Fremantle Hospitals Group, Perth, WA, Australia., Seymour H; Department of Geriatric Medicine, Fiona Stanley Fremantle Hospitals Group, Perth, WA, Australia.
مؤلفون مشاركون: Fragility Fracture Network Hip Fracture Audit Special Interest Group
المصدر: Anaesthesia [Anaesthesia] 2024 Jun; Vol. 79 (6), pp. 627-637. Date of Electronic Publication: 2024 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0370524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2044 (Electronic) Linking ISSN: 00032409 NLM ISO Abbreviation: Anaesthesia Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, UK : Wiley-Blackwell
Original Publication: London, Academic Press; New York, Grune & Stratton.
مواضيع طبية MeSH: Hip Fractures*/surgery , Anticoagulants*/therapeutic use , Anticoagulants*/administration & dosage , Consensus*, Humans ; Aged ; Administration, Oral ; Delphi Technique ; Nerve Block/methods ; Anesthesia, General ; Aged, 80 and over ; Anesthesia, Spinal/methods
مستخلص: Hip fracture is a common serious injury among older adults, yet the management of hip fractures for patients taking direct oral anticoagulants remains inconsistent worldwide. Drawing from a synthesis of available evidence and expert opinion, best practice approaches for managing patients with a hip fracture and who are taking direct oral anticoagulants pre-operatively were considered by a working group of the Fragility Fracture Network Hip Fracture Audit Special Interest Group. The literature and related clinical guidelines were reviewed and a two-round modified Delphi study was conducted with a panel of experts from 16 countries and involved seven clinical specialities. Four consensus statements were achieved: peripheral nerve blocks can reasonably be performed on presentation for patients with hip fracture who are receiving direct oral anticoagulants; hip fracture surgery can reasonably be performed for patients taking direct oral anticoagulants < 36 h from last dose; general anaesthesia could reasonably be administered for patients with hip fracture and who are taking direct oral anticoagulants < 36 h from last dose (assuming eGFR > 60 ml.min -1 .1.73 m -2 ); and it is generally reasonable to consider recommencing direct oral anticoagulants (considering blood loss and haemoglobin) < 48 h after hip fracture surgery. No consensus was achieved regarding timing of spinal anaesthesia. The consensus statements were developed to aid clinicians in their decision-making and to reduce practice variations in the management of patients with hip fracture and who are taking direct oral anticoagulants. Each statement will need to be considered specific to each individual patient's treatment.
(© 2024 Association of Anaesthetists.)
References: Griffiths R, Babu S, Dixon P, et al. Guideline for the management of hip fractures 2020: guideline by the association of anaesthetists. Anaesthesia 2021; 76: 225–237.
Horlocker TT, Vandermeuelen E, Kopp S, Gogarten W, Leffert L, Benzon H. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of regional anesthesia and pain medicine evidence‐based guidelines (fourth edition). Regional Anesthesia and Pain Medicine 2018; 43: 263–309.
Steffel J, Verhamme P, Potpara TS, et al. The 2018 European Heart Rhythm Association practical guide on the use of non‐vitamin k antagonist oral anticoagulants in patients with atrial fibrillation. European Heart Journal 2018; 39: 1330–1393.
Narouze S, Benzon HT, Provenzano D, et al. Interventional spine and pain procedures in patients on antiplatelet and anticoagulant medications: guidelines from the American Society of Regional Anesthesia and Pain Medicine, the European Society of Regional Anaesthesia and Pain Therapy, the American Academy of Pain Medicine, the International Neuromodulation Society, the North American Neuromodulation Society, and the World Institute of Pain. Regional Anesthesia and Pain Medicine 2018; 43: 225–262.
Douketis JD, Spyropoulos AC, Murad MH, et al. Perioperative management of antithrombotic therapy: an American college of chest physicians clinical practice guideline. Chest 2022; 162: e207–e243.
The ICM‐VTE Trauma Delegates. Recommendations from the ICM‐VTE: Trauma. Journal of Bone and Joint Surgery 2022; 104: 280–308.
Kietaibl S, Ferrandis R, Godier A, et al. Regional anaesthesia in patients on antithrombotic drugs: joint ESAIC/ESRA guidelines. European Journal of Anaesthesiology 2022; 39: 100–132.
Harvey N, Dennison E, Cooper C. Osteoporosis: impact on health and economics. Nature Reviews Rheumatology 2010; 6: 99–105.
Dyer SM, Crotty M, Fairhall N, et al. A critical review of the long‐term disability outcomes following hip fracture. BMC Geriatrics 2016; 16: 158.
Pincus D, Ravi B, Wasserstein D, et al. Association between wait time and 30‐day mortality in adults undergoing hip fracture surgery. JAMA 2017; 318: 1994–2003.
Borges FK, Bhandari M, Guerra‐Farfan E, et al. Accelerated surgery versus standard care in hip fracture (hip attack): an international, randomised, controlled trial. Lancet 2020; 395: 698–708.
Simunovic N, Devereaux PJ, Sprague S, Guyatt GH, Schemitsch E, DeBeer J, Bhandari M. Effect of early surgery after hip fracture on mortality and complications: systematic review and meta‐analysis. Canadian Medical Association Journal 2010; 182: 1609–1616.
Moja L, Piatti A, Pecoraro V, et al. Timing matters in hip fracture surgery: patients operated within 48 hours have better outcomes. A meta‐analysis and meta‐regression of over 190,000 patients. PLoS One 2012; 7: e46175‐e.
Leer‐Salvesen S, Engesæter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen J‐E. Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients? An observational study of 73 557 patients reported to the Norwegian hip fracture register. Bone and Joint Journal 2019; 101‐B: 1129–1137.
Klestil T, Röder C, Stotter C, et al. Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta‐analysis. Scientific Reports 2018; 8: 13933.
Orosz GM, Magaziner J, Hannan EL, et al. Association of timing of surgery for hip fracture and patient outcomes. JAMA 2004; 291: 1738–1743.
National Institute for Health and Care Excellence. Hip fracture: management. [CG124]. 2011. https://www.nice.org.uk/guidance/cg124.
Australian and New Zealand Hip Fracture Registry Steering Group. Australian and New Zealand guideline for hip fracture care: Improving outcomes in hip fracture management of adults. 2014.
Roberts KC, Brox WT, Jevsevar DS, Sevarino K. Management of hip fractures in the elderly. Journal of the American Academy of Orthopaedic Surgeons 2015; 23: 131–137.
Kirley K, Qato DM, Kornfield R, Stafford RS, Alexander GC. National trends in oral anticoagulant use in the United States, 2007 to 2011. Circulation: Cardiovascular Quality and Outcomes 2012; 5: 615–621.
Morgan A, Joshy G, Schaffer A, Laba TL, Litchfield M, Pearson S, Banks E. Rapid and substantial increases in anticoagulant use and expenditure in Australia following the introduction of new types of oral anticoagulants. PLoS One 2018; 13: e0208824‐e.
Taranu R, Redclift C, Williams P, et al. Use of anticoagulants remains a significant threat to timely hip fracture surgery. Geriatric Orthopaedic Surgery and Rehabilitation 2018; 9: 2151459318764150.
Zhu J, Alexander GC, Nazarian S, Segal JB, Wu AW. Trends and variation in oral anticoagulant choice in patients with atrial fibrillation, 2010‐2017. Pharmacotherapy 2018; 38: 907–920.
Colacci M, Tseng EK, Sacks CA, Fralick M. Oral anticoagulant utilization in the United States and United Kingdom. Journal of General Internal Medicine 2020; 35: 2505–2507.
Daugaard C, Pedersen AB, Kristensen NR, Johnsen SP. Preoperative antithrombotic therapy and risk of blood transfusion and mortality following hip fracture surgery: a Danish nationwide cohort study. Osteoporosis International 2019; 30: 583–591.
Lizaur‐Utrilla A, Martinez‐Mendez D, Collados‐Maestre I, Miralles‐Muñoz FA, Marco‐Gomez L, Lopez‐Prats FA. Early surgery within 2 days for hip fracture is not reliable as healthcare quality indicator. Injury 2016; 47: 1530–1535.
Dailiana Z, Papakostidou I, Varitimidis S, Michalitsis S, Veloni A, Malizos K. Surgical treatment of hip fractures: factors influencing mortality. Hippokratia 2013; 17: 252–257.
Papachristos IV, Giannoudis PV. Proximal femur fractures in patients taking anticoagulants. EFORT Open Reviews 2020; 5: 699–706.
Shah R, Sheikh N, Mangwani J, Morgan N, Khairandish H. Direct oral anticoagulants (DOACS) and neck of femur fractures: Standardising the perioperative management and time to surgery. Journal of Clinical Orthopaedics and Trauma 2021; 12: 138–147.
Aziz S, Almeida K, Taylor G. How should we manage hip fracture patients on direct oral anticoagulants? BMJ Evidence‐Based Medicine 2021; 26: 22–23.
Mitchell RJ, Jakobs S, Halim N, Seymour H, Tarrant S. Synthesis of the evidence on the impact of pre‐operative direct oral anticoagulants on patient health outcomes after hip fracture surgery: rapid systematic review. European Journal of Trauma and Emergency Surgery 2022; 48: 2567–2587.
You D, Xu Y, Ponich B, et al. Effect of oral anticoagulant use on surgical delay and mortality in hip fracture: a systematic review and meta‐analysis. Bone and Joint Journal 2021; 103: 222–233.
White SM, Altermatt F, Barry J, et al. International fragility fracture network Delphi consensus statement on the principles of anaesthesia for patients with hip fracture. Anaesthesia 2018; 73: 863–874.
WikiGuidelines. Wikiguidelines charter. 2022. https://www.wikiguidelines.com/charter.
Kidney Disease Improving Global Outcomes. Consensus Conference on Nomenclature for kidney Function and Disease. Amsterdam. 2019. https://kdigo.org/conferences/nomenclature.
Sharkey SB, Sharples AY. An approach to consensus building using the Delphi technique: developing a learning resource in mental health. Nurse Education Today 2001; 21: 398–408.
Dayan RR, Ayzenberg Y, Slutsky T, Shaer E, Kaplan A, Zeldetz V. Safety of femoral nerve blockage for hip fractures in adult patients treated with anti‐xa direct oral anticoagulants: a pilot study. Israel Medical Association Journal 2021; 23: 590–594.
Guay J, Kopp S. Peripheral nerve blocks for hip fractures in adults. Cochrane Database of Systematic Reviews 2020; 11: CD001159.
Levack AE, Moore HG, Stephan S, et al. Delayed surgery does not reduce transfusion rates in low‐energy hip fractures on direct oral anticoagulants. Journal of Orthopaedic Trauma 2022; 36: 172–178.
Aigner R, Buecking B, Hack J, et al. Effect of direct oral anticoagulants on treatment of geriatric hip fracture patients: an analysis of 15,099 patients of the AltersTraumaRegister DGU®. Medicina (Kaunas, Lithuania) 2022; 58: 379.
Brown A, Zmich Z, Roberts A, Lipof J, Judd KT. Expedited surgery in geriatric hip fracture patients taking direct oral anticoagulants is not associated with increased short‐term complications or mortality rates. OTA International 2020; 3: e089.
Cafaro T, Simard C, Tagalakis V, Koolian M. Delayed time to emergency hip surgery in patients taking oral anticoagulants. Thrombosis Research 2019; 184: 110–114.
Frenkel Rutenberg T, Velkes S, Vitenberg M, et al. Morbidity and mortality after fragility hip fracture surgery in patients receiving vitamin k antagonists and direct oral anticoagulants. Thrombosis Research 2018; 166: 106–112.
Gill SK, Theodorides A, Smith N, Maguire E, Whitehouse SL, Rigby MC, Ivory JP. Wound problems following hip arthroplasty before and after the introduction of a direct thrombin inhibitor for thromboprophylaxis. Hip International 2011; 21: 678–683.
Hourston GJM, Barrett MP, Khan WS, Vindlacheruvu M, McDonnell SM. New drug, new problem: do hip fracture patients taking NOACS experience delayed surgery, longer hospital stay, or poorer outcomes? Hip International 2020; 30: 799–804.
King K, Polischuk M, Lynch G, et al. Early surgical fixation for hip fractures in patients taking direct oral anticoagulation: a retrospective cohort study. Geriatric Orthopaedic Surgery and Rehabilitation 2020; 11: 2151459320944854.
Krespi R, Ashkenazi I, Shaked O, Kleczewski J, Ben‐Tov T, Steinberg E, Khoury A. Early versus delayed surgery for hip fragility fractures in patients treated with direct oral anticoagulants. Archives of Orthopaedic and Trauma Surgery 2022; 142: 3279–3284.
Lott A, Haglin J, Belayneh R, Konda SR, Leucht P, Egol KA. Surgical delay is not warranted for patients with hip fractures receiving non‐warfarin anticoagulants. Orthopedics 2019; 42: E331–E335.
Mahmood A, Thornton L, Whittam DG, Maskell P, Hawkes DH, Harrison WJ. Pre‐injury use of antiplatelet and anticoagulations therapy are associated with increased mortality in a cohort of 1038 hip fracture patients. Injury 2021; 52: 1473–1479.
Mayor A, Brooke B, Stephenson J. Reducing delays to surgery and achieving best practice tariff for hip fracture patients on direct oral anticoagulants (DOACS): a protocol for expediting surgery without increasing peri‐operative complications. Trauma 2023. Epub 6 April. https://doi.org/10.1177/14604086231165567.
Schermann H, Gurel R, Gold A, Maman E, Dolkart O, Steinberg EL, Chechik O. Safety of urgent hip fracture surgery protocol under influence of direct oral anticoagulation medications. Injury 2019; 50: 398–402.
Shani M, Yahalom R, Comaneshter D, Holtzman K, Blickstein D, Cohen A, Lustman A. Should patients treated with oral anti‐coagulants be operated on within 48 h of hip fracture? Journal of Thrombosis and Thrombolysis 2021; 51: 1132–1137.
Goh EL, Chidambaram S, Rai S, Kannan A, Anand S. Timing of surgery for hip fracture in patients on direct oral anti‐coagulants: a population‐based cohort study. Geriatric Orthopaedic Surgery and Rehabilitation 2022; 13. https://doi.org/10.1177/21514593221088405.
Franklin NA, Ali AH, Hurley RK, Mir HR, Beltran MJ. Outcomes of early surgical intervention in geriatric proximal femur fractures among patients receiving direct oral anticoagulation. Journal of Orthopaedic Trauma 2018; 32: 269–273.
Mullins B, Akehurst H, Slattery D, Chesser T. Should surgery be delayed in patients taking direct oral anticoagulants who suffer a hip fracture? A retrospective, case‐controlled observational study at a UK major trauma centre. BMJ Open 2018; 8: e020625.
Tarrant SM, Catanach MJ, Sarrami M, Clapham M, Attia J, Balogh ZJ. Direct oral anticoagulants and timing of hip fracture surgery. Journal of Clinical Medicine 2020; 9: 2200.
Tran T, Delluc A, de Wit C, Petrcich W, Le Gal G, Carrier M. The impact of oral anticoagulation on time to surgery in patients hospitalized with hip fracture. Thrombosis Research 2015; 136: 962–965.
Bruckbauer M, Prexl O, Voelckel W, Ziegler B, Grottke O, Maegele M, Schöchl H. Impact of direct oral anticoagulants in patients with hip fractures. Journal of Orthopaedic Trauma 2019; 33: E8–E13.
Leer‐Salvesen S, Dybvik E, Ranhoff AH, Husebø BL, Dahl OE, Engesæter LB, Gjertsen JE. Do direct oral anticoagulants (doacs) cause delayed surgery, longer length of hospital stay, and poorer outcome for hip fracture patients? European Geriatric Medicine 2020; 11: 563–569.
Neuman MD, Ellenberg SS, Sieber FE, Magaziner JS, Feng R, Carson JL. Regional versus general anesthesia for promoting independence after hip fracture (REGAIN): protocol for a pragmatic, international multicentre trial. BMJ Open 2016; 6: e013473.
Li T, Li J, Yuan L, et al. Effect of regional vs general anesthesia on incidence of postoperative delirium in older patients undergoing hip fracture surgery: the RAGA randomized trial. JAMA 2022; 327: 50–58.
White SM, Moppett I, Griffiths R, et al. Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK anaesthesia sprint audit of practice (ASAP‐2). Anaesthesia 2016; 71: 506–514.
Anazor F, Kulkarni A, Barnard K, Lancaster S, Pollard T. Timing and safety of hip fracture surgery in patients on direct‐acting oral anticoagulants. Journal of Clinical Orthopaedics and Trauma 2023; 36: 102080.
Chaudhary R, Sharma T, Garg J, et al. Direct oral anticoagulants: a review on the current role and scope of reversal agents. Journal of Thrombosis and Thrombolysis 2020; 49: 271–286.
Alanie M, Eardley W, Baxter M, Kottam L. A multicentre prospective service evaluation of timing of surgery in older hip and femoral fracture patients on oral anticoagulants: South Tees: James Cook University Hospital, 2023. https://www.southtees.nhs.uk/about/strive/research‐team/aces/world‐leading/present/haste‐study‐hip‐and‐femoral‐fracture‐anticoagulation‐surgical‐timing‐evaluation.
فهرسة مساهمة: Keywords: DOAC; guidelines; hip fracture; surgery
المشرفين على المادة: 0 (Anticoagulants)
تواريخ الأحداث: Date Created: 20240206 Date Completed: 20240510 Latest Revision: 20240510
رمز التحديث: 20240510
DOI: 10.1111/anae.16226
PMID: 38319797
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2044
DOI:10.1111/anae.16226