دورية أكاديمية
أعرض في EDS

LSD1 controls a nuclear checkpoint in Wnt/β-Catenin signaling to regulate muscle stem cell self-renewal.

التفاصيل البيبلوغرافية
العنوان: LSD1 controls a nuclear checkpoint in Wnt/β-Catenin signaling to regulate muscle stem cell self-renewal.
المؤلفون: Mouradian S; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Cicciarello D; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Lacoste N; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Risson V; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Berretta F; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Le Grand F; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS974, CNRS FRE3617, Center for Research in Myology, 75013 Paris, France., Rose N; Sorbonne Université, UPMC Université Paris 06, INSERM UMRS974, CNRS FRE3617, Center for Research in Myology, 75013 Paris, France., Simonet T; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France., Schaeffer L; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France.; Centre de Biotechnologie Cellulaire, Hospices Civils de Lyon, groupement Est, Bron, France., Scionti I; Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, INSERM U1315, Faculté de Médecine Rockefeller, France.
المصدر: Nucleic acids research [Nucleic Acids Res] 2024 Apr 24; Vol. 52 (7), pp. 3667-3681.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Histone Demethylases*/metabolism , Histone Demethylases*/genetics , Wnt Signaling Pathway* , beta Catenin*/metabolism , beta Catenin*/genetics , Cell Self Renewal*/genetics, Animals ; Mice ; Cell Nucleus/metabolism ; Spindle Apparatus/metabolism ; Cell Differentiation/genetics ; Humans ; Stem Cells/metabolism ; Stem Cells/cytology
مستخلص: The Wnt/β-Catenin pathway plays a key role in cell fate determination during development and in adult tissue regeneration by stem cells. These processes involve profound gene expression and epigenome remodeling and linking Wnt/β-Catenin signaling to chromatin modifications has been a challenge over the past decades. Functional studies of the lysine demethylase LSD1/KDM1A converge to indicate that this epigenetic regulator is a key regulator of cell fate, although the extracellular cues controlling LSD1 action remain largely unknown. Here we show that β-Catenin is a substrate of LSD1. Demethylation by LSD1 prevents β-Catenin degradation thereby maintaining its nuclear levels. Consistently, in absence of LSD1, β-Catenin transcriptional activity is reduced in both MuSCs and ESCs. Moreover, inactivation of LSD1 in mouse muscle stem cells and embryonic stem cells shows that LSD1 promotes mitotic spindle orientation via β-Catenin protein stabilization. Altogether, by inscribing LSD1 and β-Catenin in the same molecular cascade linking extracellular factors to gene expression, our results provide a mechanistic explanation to the similarity of action of canonical Wnt/β-Catenin signaling and LSD1 on stem cell fate.
(© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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معلومات مُعتمدة: Alliance MyoNeurALP1 Association Française Contre les Myopathies; ANR-11-BSV2-017-01 Agence Nationale de la Recherche; Fondation pour le Recherche Medicale
المشرفين على المادة: EC 1.14.11.- (Histone Demethylases)
0 (beta Catenin)
EC 1.14.11.- (KDM1a protein, mouse)
تواريخ الأحداث: Date Created: 20240207 Date Completed: 20240424 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC11040000
DOI: 10.1093/nar/gkae060
PMID: 38321961
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkae060