دورية أكاديمية
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Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy.

التفاصيل البيبلوغرافية
العنوان: Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy.
المؤلفون: Sint Jago SC; Department of Neurobiology, University of Alabama at Birmingham, United States., Bahabry R; Department of Neurobiology, University of Alabama at Birmingham, United States., Schreiber AM; Department of Neurobiology, University of Alabama at Birmingham, United States., Homola J; Department of Neurobiology, University of Alabama at Birmingham, United States., Ngyuen T; Department of Neurobiology, University of Alabama at Birmingham, United States., Meijia F; Department of Neurobiology, University of Alabama at Birmingham, United States., Allendorfer JB; Department of Neurobiology, University of Alabama at Birmingham, United States.; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States., Lubin FD; Department of Neurobiology, University of Alabama at Birmingham, United States.
المصدر: Epilepsy & behavior reports [Epilepsy Behav Rep] 2023 Dec 29; Vol. 25, pp. 100642. Date of Electronic Publication: 2023 Dec 29 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101750909 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-9864 (Electronic) Linking ISSN: 25899864 NLM ISO Abbreviation: Epilepsy Behav Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier Inc., [2019]-
مستخلص: The therapeutic potential of aerobic exercise in mitigating seizures and cognitive issues in temporal lobe epilepsy (TLE) is recognized, yet the underlying mechanisms are not well understood. Using a rodent TLE model induced by Kainic acid (KA), we investigated the impact of a single bout of exercise (i.e., acute) or 4 weeks of aerobic exercise (i.e., chronic). Blood was processed for epilepsy-associated serum markers, and DNA methylation (DNAme), and hippocampal area CA3 was assessed for gene expression levels for DNAme-associated enzymes. While acute aerobic exercise did not alter serum Brain-Derived Neurotrophic Factor (BDNF) or Interleukin-6 (IL-6), chronic exercise resulted in an exercise-specific decrease in serum BDNF and an increase in serum IL-6 levels in epileptic rats. Additionally, whole blood DNAme levels, specifically 5-hydroxymethylcytosine (5-hmC), decreased in epileptic animals following chronic exercise. Hippocampal CA3 5-hmC levels and ten-eleven translocation protein (TET1) expression mirrored these changes. Furthermore, immunohistochemistry analysis revealed that most 5-hmC changes in response to chronic exercise were neuron-specific within area CA3 of the hippocampus. Together, these findings suggest that DNAme mechanisms in the rodent model of TLE are responsive to chronic aerobic exercise, with emphasis on neuronal 5-hmC DNAme in the epileptic hippocampus.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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فهرسة مساهمة: Keywords: 5-hydroxymethylcytosine; Acute exercise; Astrocytes; Chronic exercise; Epigenetics; Neurons; Ten-eleven translocation
تواريخ الأحداث: Date Created: 20240207 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10844942
DOI: 10.1016/j.ebr.2023.100642
PMID: 38323091
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-9864
DOI:10.1016/j.ebr.2023.100642