Editorial & Opinion
Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer.
| العنوان: | Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer. |
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| المؤلفون: | Qian ST; Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China., Xie FF; Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China., Zhao HY; Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China., Liu QS; Science and Education Section, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China., Cai DL; Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 311122, Zhejiang Province, China. 13858159603@139.com. |
| المصدر: | World journal of gastrointestinal surgery [World J Gastrointest Surg] 2024 Jan 27; Vol. 16 (1), pp. 6-12. |
| نوع المنشور: | Editorial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101532473 Publication Model: Print Cited Medium: Print ISSN: 1948-9366 (Print) NLM ISO Abbreviation: World J Gastrointest Surg Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Baishideng |
| مستخلص: | Gastric cancer (GC) is a prevalent malignant tumor within the digestive system, with over 40% of new cases and deaths related to GC globally occurring in China. Despite advancements in treatment modalities, such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents, the prognosis for GC remains poor. New targeted therapies and immunotherapies are currently under investigation, but no significant breakthroughs have been achieved. Studies have indicated that GC is a heterogeneous disease, encompassing multiple subtypes with distinct biological characteristics and roles. Consequently, personalized treatment based on clinical features, pathologic typing, and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer (PLGC). Current research has categorized GC into four subtypes: Epstein-Barr virus-positive, microsatellite instability, genome stability, and chromosome instability (CIN). Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas. Among these, ultrasensitive chromosomal aneuploidy detection (UCAD) can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology, in conjunction with bioinformatics analysis, to achieve qualitative and quantitative detection of chromosomal stability. This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC. Competing Interests: Conflict-of-interest statement: All authors have no conflict-of-interest to disclose. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: Adjuvant therapy; Application prospects; Gastric cancer; Molecular typing; Precancerous lesions of gastric cancer; Ultrasensitive chromosomal aneuploidy detection |
| تواريخ الأحداث: | Date Created: 20240208 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10845279 |
| DOI: | 10.4240/wjgs.v16.i1.6 |
| PMID: | 38328310 |
| قاعدة البيانات: | MEDLINE |
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