دورية أكاديمية
Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity.
| العنوان: | Thalamic deep brain stimulation for tourette syndrome increases cortical beta activity. |
|---|---|
| المؤلفون: | Schüller T; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 50935, Cologne, Germany. Electronic address: thomas.schueller@uk-koeln.de., Huys D; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 50935, Cologne, Germany., Kohl S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 50935, Cologne, Germany., Visser-Vandewalle V; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Stereotactic and Functional Surgery, 50935, Cologne, Germany., Dembek TA; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50935, Cologne, Germany., Kuhn J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 50935, Cologne, Germany; Johanniter Hospital Oberhausen, Department of Psychiatry and Psychotherapy & Psychosomatic Medicine, 46145, Oberhausen, Germany., Baldermann JC; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 50935, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50935, Cologne, Germany; University of Freiburg, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, 79104, Freiburg, Germany., Smith EE; Tucson VA Medical Center, Tucson, AZ, USA. |
| المصدر: | Brain stimulation [Brain Stimul] 2024 Mar-Apr; Vol. 17 (2), pp. 197-201. Date of Electronic Publication: 2024 Feb 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101465726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-4754 (Electronic) Linking ISSN: 18764754 NLM ISO Abbreviation: Brain Stimul Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Tourette Syndrome*/therapy , Tourette Syndrome*/physiopathology , Deep Brain Stimulation*/methods , Thalamus*/physiopathology , Thalamus*/physiology , Beta Rhythm*/physiology, Humans ; Male ; Adult ; Female ; Electroencephalography ; Young Adult ; Cerebral Cortex/physiopathology ; Cerebral Cortex/physiology ; Middle Aged ; Adolescent |
| مستخلص: | Background: Deep brain stimulation (DBS) of the thalamus can effectively reduce tics in severely affected patients with Tourette syndrome (TS). Its effect on cortical oscillatory activity is currently unknown. Objective: We assessed whether DBS modulates beta activity at fronto-central electrodes. We explored concurrent EEG sources and probabilistic stimulation maps. Methods: Resting state EEG of TS patients treated with thalamic DBS was recorded in repeated DBS-on and DBS-off states. A mixed linear model was employed for statistical evaluation. EEG sources were estimated with eLORETA. Thalamic probabilistic stimulation maps were obtained by assigning beta power difference scores (DBS-on minus DBS-off) to stimulation sites. Results: We observed increased beta power in DBS-on compared to DBS-off states. Modulation of cortical beta activity was localized to the midcingulate cortex. Beta modulation was more pronounced when stimulating the thalamus posteriorly, peaking in the ventral posterior nucleus. Conclusion: Thalamic DBS in TS patients modulates beta frequency oscillations presumably important for sensorimotor function and relevant to TS pathophysiology. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Beta oscillations; Deep brain stimulation; Midcingulate cortex; Tourette syndrome; Ventral posterior thalamus |
| تواريخ الأحداث: | Date Created: 20240210 Date Completed: 20240430 Latest Revision: 20240430 |
| رمز التحديث: | 20240430 |
| DOI: | 10.1016/j.brs.2024.01.011 |
| PMID: | 38341176 |
| قاعدة البيانات: | MEDLINE |
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