دورية أكاديمية
Structural and therapeutic properties of salicylic acid-solubilized Pluronic solutions and hydrogels.
| العنوان: | Structural and therapeutic properties of salicylic acid-solubilized Pluronic solutions and hydrogels. |
|---|---|
| المؤلفون: | Ganguly R; Chemistry Division, Bhabha Atomic Research Centre, Mumbai-400085, India. rajibg@barc.gov.in., Kumar S; Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai-400085, India., Soumya M; Nuclear Agriculture & Biotech Division, Bhabha Atomic Research Centre, Mumbai-400085, India., Khare A; Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400085, India., Bhainsa KC; Nuclear Agriculture & Biotech Division, Bhabha Atomic Research Centre, Mumbai-400085, India., Aswal VK; Solid State Physics Division, Bhabha Atomic Research Centre, Mumbai-400085, India., Kohlbrecher J; Paul Scherrer Institut, Villingen 5232, Switzerland. |
| المصدر: | Soft matter [Soft Matter] 2024 Feb 28; Vol. 20 (9), pp. 2075-2087. Date of Electronic Publication: 2024 Feb 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101295070 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-6848 (Electronic) Linking ISSN: 1744683X NLM ISO Abbreviation: Soft Matter Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, England : Royal Society of Chemistry, 2005- |
| مواضيع طبية MeSH: | Poloxamer*/chemistry , Hydrogels* , Poloxalene* , Polyethylenes* , Polypropylenes*, Salicylic Acid/pharmacology ; Anti-Bacterial Agents ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Micelles |
| مستخلص: | Salicylic acid (SA) finds extensive applications in the treatment of rheumatic and skin diseases because of its analgesic, anti-inflammatory and exfoliating properties. As it is lipophilic in nature, there is a need for appropriate delivery systems to harness these properties for different applications. Herein, we examined the suitability of Pluronic P123/F127 micellar systems as delivery media by investigating the structural, flow and antimicrobial properties of P123/F127-SA solutions and hydrogels using DLS, SANS, rheological and zone inhibition measurement techniques. SA modulates the aggregation characteristics of these surfactant systems and brings about spherical-to-worm-like micelle-to-vesicular structural transitions in the hydrophobic Pluronic P123 system, a spherical-to-worm-like micellar transition in the mixed P123/F127 system and an onset of inter-micellar attraction in the hydrophilic Pluronic F127 system. SA-solubilized systems of both hydrophobic and hydrophilic Pluronics inhibit the growth of Gram-positive and Gram-negative bacteria with comparable MIC values. This suggests that the interaction of SA molecules with the bacterial cell membrane remains unobstructed upon encapsulation in Pluronic micelles. F127 hydrogel-based SA formulations with rheological properties suitable for topical applications and up to 15% SA loading were prepared. These will be useful SA ointments as F127 is an FDA-approved excipient for topical drug delivery applications. The results indicate that Pluronics remain effective as delivery agents for SA and exhibit interesting structural polymorphism upon its solubilization. |
| المشرفين على المادة: | 2E9U4Y94DB (pluronic block copolymer P123) 106392-12-5 (Poloxamer) 9038-95-3 (UCON 50-HB-5100) 0 (Hydrogels) O414PZ4LPZ (Salicylic Acid) 0 (Anti-Bacterial Agents) 0 (Micelles) 9003-11-6 (Poloxalene) 0 (Polyethylenes) 0 (Polypropylenes) |
| تواريخ الأحداث: | Date Created: 20240212 Date Completed: 20240229 Latest Revision: 20240229 |
| رمز التحديث: | 20240229 |
| DOI: | 10.1039/d4sm00079j |
| PMID: | 38345756 |
| قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!