دورية أكاديمية
Paraseptal Emphysema in Indium Lung: Tracing the Pathological Footprints of Chronic Exposure.
| العنوان: | Paraseptal Emphysema in Indium Lung: Tracing the Pathological Footprints of Chronic Exposure. |
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| المؤلفون: | Inoue C; Department of Anatomic Pathology, Tohoku University Graduate School of Medicine., Amata A; Department of Medicine, Nikko Memorial Hospital., Chonan T; Department of Medicine, Nikko Memorial Hospital., Kawabata Y; Division of Diagnostic Pathology, Saitama Prefectural Cardiovascular and Respiratory Center., Matsuno Y; Department of Medicine, Nikko Memorial Hospital., Suzuki T; Department of Anatomic Pathology, Tohoku University Graduate School of Medicine. |
| المصدر: | The Tohoku journal of experimental medicine [Tohoku J Exp Med] 2024 May 30; Vol. 263 (1), pp. 51-54. Date of Electronic Publication: 2024 Mar 15. |
| نوع المنشور: | Journal Article; Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3329 (Electronic) Linking ISSN: 00408727 NLM ISO Abbreviation: Tohoku J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sendai : Tohoku University Medical Library |
| مواضيع طبية MeSH: | Indium*/toxicity , Lung*/pathology , Lung*/diagnostic imaging , Pulmonary Emphysema*/pathology , Pulmonary Emphysema*/diagnostic imaging, Humans ; Occupational Exposure/adverse effects ; Tin Compounds ; Tomography, X-Ray Computed |
| مستخلص: | Indium lung is an occupational lung disease caused by exposure to indium-tin-oxide (ITO) dust. Compared to other occupational lung diseases, indium lung has a shorter latency period and the respiratory status continues to worsen even after exposure to the work environment improves. Paraseptal emphysema which affects mainly the subpleural area is seen on chest images obtained via computed tomography (CT), regardless of the smoking history. However, the pathogenesis of emphysema in indium lung is still unclear. Therefore, we re-evaluated the pathology of three previously reported cases of indium lung. Paraseptal emphysema was observed in both smokers and nonsmokers. Obstructive respiratory impairment worsened over time in the cases with paraseptal emphysema. Many alveolar walls were destroyed independent of the presence or absence of emphysetamous changes or fibrosis. Moreover, bronchiolitis was found to be less common in indium lung than in asbestosis (the most common occupational lung disease) or common cases of chronic obstructive pulmonary disease caused by smoking. It has been shown that ITO causes protease anti-protease imbalance, oxidant-antioxidant imbalance, and continuous, abnormal inflammation (the three major causes of emphysema). In addition, nano-sized ITO is less likely to be trapped in the upper airways and may easily reach the subpleural alveoli. Furthermore, ITO may continue to cause sustained tissue injury at the alveolar level potentially resulting in emphysema. Further studies are needed to elucidate the detailed pathogenesis of indium lung by comparing it with other occupational lung diseases. |
| فهرسة مساهمة: | Keywords: indium lung; interstitial pneumonia; occupational disease; paraseptal emphysema; pathology |
| المشرفين على المادة: | 045A6V3VFX (Indium) 71243-84-0 (indium tin oxide) 0 (Tin Compounds) |
| تواريخ الأحداث: | Date Created: 20240214 Date Completed: 20240529 Latest Revision: 20240731 |
| رمز التحديث: | 20240731 |
| DOI: | 10.1620/tjem.2024.J017 |
| PMID: | 38355110 |
| قاعدة البيانات: | MEDLINE |
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