دورية أكاديمية
Left ventricle segment-specific motion assessment for cardiac-gated radiosurgery.
| العنوان: | Left ventricle segment-specific motion assessment for cardiac-gated radiosurgery. |
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| المؤلفون: | Poon J; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.; Department of Medical Physics, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada., Thompson RB; Department of Biomedical Engineering, University of Alberta, Edmonton, AB, T6G 2V2, Canada., Deyell MW; Heart Rhythm Services, Division of Cardiology, University of British Columbia, Vancouver, BC V6E 1M7, Canada., Schellenberg D; Department of Radiation Oncology, BC Cancer, Surrey, British Columbia V3V 1Z2, Canada., Kohli K; Department of Medical Physics, BC Cancer, Surrey, British Columbia V3V 1Z2, Canada., Thomas S; Department of Medical Physics, BC Cancer, Vancouver, British Columbia V5Z 4E6, Canada. |
| المصدر: | Biomedical physics & engineering express [Biomed Phys Eng Express] 2024 Feb 29; Vol. 10 (2). Date of Electronic Publication: 2024 Feb 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Publishing Ltd Country of Publication: England NLM ID: 101675002 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-1976 (Electronic) Linking ISSN: 20571976 NLM ISO Abbreviation: Biomed Phys Eng Express Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : IOP Publishing Ltd., [2015]- |
| مواضيع طبية MeSH: | Heart Failure*/therapy , Radiosurgery*/methods, Humans ; Heart Ventricles/diagnostic imaging ; Stroke Volume ; Heart/diagnostic imaging |
| مستخلص: | Purpose. Cardiac radiosurgery is a non-invasive treatment modality for ventricular tachycardia, where a linear accelerator is used to irradiate the arrhythmogenic region within the heart. In this work, cardiac magnetic resonance (CMR) cine images were used to quantify left ventricle (LV) segment-specific motion during the cardiac cycle and to assess potential advantages of cardiac-gated radiosurgery. Methods. CMR breath-hold cine images and LV contour points were analyzed for 50 controls and 50 heart failure patients with reduced ejection fraction (HFrEF, EF < 40%). Contour points were divided into anatomic segments according to the 17-segment model, and each segment was treated as a hypothetical treatment target. The optimum treatment window (one fifth of the cardiac cycle) was determined where segment centroid motion was minimal, then the maximum centroid displacement and treatment area were determined for the full cardiac cycle and for the treatment window. Mean centroid displacement and treatment area reductions with cardiac gating were determined for each of the 17 segments. Results. Full motion segment centroid displacements ranged between 6-14 mm (controls) and 4-11 mm (HFrEF). Full motion treatment areas ranged between 129-715 mm 2 (controls) and 149-766 mm 2 (HFrEF). With gating, centroid displacements were reduced to 1 mm (controls and HFrEF), while treatment areas were reduced to 62-349 mm 2 (controls) and 83-393 mm 2 (HFrEF). Relative treatment area reduction ranged between 38%-53% (controls) and 26%-48% (HFrEF). Conclusion. This data demonstrates that cardiac cycle motion is an important component of overall target motion and varies depending on the anatomic cardiac segment. Accounting for cardiac cycle motion, through cardiac gating, has the potential to significantly reduce treatment volumes for cardiac radiosurgery. (Creative Commons Attribution license.) |
| فهرسة مساهمة: | Keywords: cardiac gating; cardiac motion; cardiac radioablation; cardiac radiosurgery; cardiac stereotactic body radiation therapy; stereotactic arrhythmia radioablation |
| تواريخ الأحداث: | Date Created: 20240215 Date Completed: 20240301 Latest Revision: 20240320 |
| رمز التحديث: | 20240320 |
| DOI: | 10.1088/2057-1976/ad29a4 |
| PMID: | 38359447 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2057-1976 |
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| DOI: | 10.1088/2057-1976/ad29a4 |