دورية أكاديمية
82-rubidium positron emission tomography determined myocardial flow reserve and outcomes following cardiac revascularisation - A multicentre registry study.
| العنوان: | 82-rubidium positron emission tomography determined myocardial flow reserve and outcomes following cardiac revascularisation - A multicentre registry study. |
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| المؤلفون: | Toftholm MH; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark. Electronic address: mattias.hoejgaard.toftholm.02@regionh.dk., Højstrup S; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark. Electronic address: signe.hoejstrup.01@regionh.dk., Talleruphuus U; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Clinical Physiology and Nuclear Medicine, Denmark., Marner L; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Clinical Physiology and Nuclear Medicine, Denmark., Bjerking L; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark., Jakobsen L; Aarhus University Hospital, Department of Cardiology, Denmark., Christiansen EH; Aarhus University Hospital, Department of Cardiology, Denmark., Bouchelouche K; Aarhus University Hospital, Department of Nuclear Medicine & PET Centre, Denmark., Galatius S; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark., Prescott E; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark., Skak-Hansen KW; Copenhagen University Hospital, Bispebjerg and Frederiksberg, Department of Cardiology, Denmark. |
| المصدر: | International journal of cardiology [Int J Cardiol] 2024 Jun 15; Vol. 405, pp. 131865. Date of Electronic Publication: 2024 Feb 15. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8200291 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1874-1754 (Electronic) Linking ISSN: 01675273 NLM ISO Abbreviation: Int J Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam : Elsevier/North-Holland Biomedical Press, c1981- |
| مواضيع طبية MeSH: | Registries* , Myocardial Revascularization*/methods , Myocardial Revascularization*/statistics & numerical data , Positron-Emission Tomography*/methods , Fractional Flow Reserve, Myocardial*/physiology , Rubidium Radioisotopes*, Humans ; Male ; Female ; Aged ; Middle Aged ; Denmark/epidemiology ; Follow-Up Studies ; Treatment Outcome ; Coronary Artery Disease/surgery ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/mortality |
| مستخلص: | Background: Finding patients with chronic coronary syndromes (CCS) whom revascularization could benefit, is complicated. Myocardial flow reserve (MFR), a measurement of myocardial perfusion, has proven prognostic value on survival and risk of major adverse cardiac events (MACE). We investigated if MFR identifies who may benefit from revascularization. Methods: Among 7462 patients from Danish hospitals examined with 82 Rb PET between January 2018 and August 2020, patients with ≥5% reversible perfusion defects were followed for MACE and all-cause mortality. Associations between revascularisation (within 90 days) and outcomes according to MFR (< and ≥ 2) was assessed by Cox regression adjusted by inverse probability weighting for demographics, cardiovascular risk factors, comorbidities, and 82 Rb PET variables. Results: Of 1806 patients with ≥5% reversible perfusion defect, 893 (49%) had MFR < 2 and 491 underwent revascularisation (36.6% in MFR < 2 versus 17.9% MFR ≥ 2, p < 0.001). During a median follow-up of 37.0 [31.0-45.8 IQR] months, 251 experienced a MACE and 173 died. Revascularisation was associated with lower adjusted risk of all-cause mortality (hazard ratio [HR], 0.51 [95% CI, 0.30-0.88], p = 0.015) and MACE (HR, 0.54 [0.33-0.87], p = 0.012) in patients with MFR < 2 but not MFR ≥ 2 for all-cause mortality (HR 1.33 [0.52-3.40], p = 0.542) and MACE (HR 1.50 [0.79-2.84], p = 0.211). MFR significantly modified the association between revascularisation and MACE, but not all-cause mortality (interaction p-value 0.021 and 0.094, respectively). Conclusions: Revascularization was associated with improved prognosis among patients with impaired MFR. No association was seen in patients with normal MFR. In patients with regional ischemia, MFR may identify patients with a prognostic benefit from revascularization. Competing Interests: Declaration of competing interest The authors report no relationships that could be construed as a conflict of interest. (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: AND cardiac revascularisation; AND chronic coronary syndromes; AND coronary artery disease; AND coronary circulation; AND survival; Myocardial flow reserve |
| المشرفين على المادة: | 0 (Rubidium Radioisotopes) 9K730EL8KU (Rubidium-82) |
| تواريخ الأحداث: | Date Created: 20240216 Date Completed: 20240426 Latest Revision: 20240426 |
| رمز التحديث: | 20240427 |
| DOI: | 10.1016/j.ijcard.2024.131865 |
| PMID: | 38365013 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1874-1754 |
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| DOI: | 10.1016/j.ijcard.2024.131865 |