دورية أكاديمية
أعرض في EDS

Blastocysts from partial compaction morulae are not defined by their early mistakes.

التفاصيل البيبلوغرافية
العنوان: Blastocysts from partial compaction morulae are not defined by their early mistakes.
المؤلفون: Parriego M; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain. Electronic address: monpar@dexeus.com., Coll L; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain., Carrasco B; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain., Garcia S; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain., Boada M; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain., Polyzos NP; Reproductive Medicine Unit, Department of Obstetrics, Gynaecology and Reproduction. Dexeus Mujer. Dexeus University Hospital. Gran Via Carles III, 71-75. 08028 Barcelona, Spain., Vidal F; Unitat de Biologia Cel·lular, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain., Veiga A; Barcelona Stem Cell Bank, IDIBELL Programme for Regenerative Medicine, 08908 L'Hospitalet de Llobregat, Spain.
المصدر: Reproductive biomedicine online [Reprod Biomed Online] 2024 Apr; Vol. 48 (4), pp. 103729. Date of Electronic Publication: 2023 Nov 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101122473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-6491 (Electronic) Linking ISSN: 14726483 NLM ISO Abbreviation: Reprod Biomed Online Subsets: MEDLINE
أسماء مطبوعة: Publication: <2009->: Amsterdam : Elsevier
Original Publication: Cambridge, UK : Reproductive Healthcare Ltd.
مواضيع طبية MeSH: Preimplantation Diagnosis*/methods, Humans ; Pregnancy ; Female ; Retrospective Studies ; Morula ; Embryo Implantation/physiology ; Genetic Testing/methods ; Aneuploidy ; Blastocyst/pathology
مستخلص: Research Question: Is partial compaction during morula formation associated with an embryo's developmental ability and implantation potential?
Design: Retrospective analysis of data from 196 preimplantation genetic testing for aneuploidy (PGT-A) cycles. Embryos starting compaction were grouped according to the inclusion or not of all the blastomeres in the forming morula (full compaction or partial compaction). The possible effect of maternal age and ovarian response on compaction was analysed. Morphokinetic characteristics, blastocyst formation rate, morphology and cytogenetic constitution of the obtained blastocysts were compared. Comparisons of reproductive outcomes after the transfer of euploid blastocysts from both groups were established. Finally, in a subset of embryos, the chromosomal constitution concordance of the abandoned cells and the corresponding blastocyst through trophectoderm biopsies was assessed.
Results: A total of 430 embryos failed to include at least one cell during compaction (partial compaction group [49.3%]), whereas the 442 remaining embryos formed a fully compacted morula (full compaction group [50.7%]). Neither female age nor the number of oocytes collected affected the prevalence of partial compaction morulae. Morphokinetic parameters were altered in embryos from partial compaction morulae compared with full compaction. Although an impairment in blastocyst formation rate was observed in partial compaction morulae (57.2% versus 70.8%, P < 0.001), both chromosomal constitution (euploidy rate: partial compaction [38.4%] versus full compaction [34.2%]) and reproductive outcomes (live birth rate: partial compaction [51.9%] versus full compaction [46.2%]) of the obtained blastocysts were equivalent between groups. A high ploidy correlation of excluded cells-trophectoderm duos was observed.
Conclusions: Partial compaction morulae show a reduced developmental ability compared with full compaction morulae. Resulting blastocysts from both groups, however, have similar euploidy rates and reproductive outcomes. Cell exclusion might be a consequence of a compromised embryo development regardless of the chromosomal constitution of the excluded cells.
(Copyright © 2023 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Aneuploidy; Blastocyst; Cell exclusion; Compaction; Implantation; Morula
تواريخ الأحداث: Date Created: 20240217 Date Completed: 20240422 Latest Revision: 20240924
رمز التحديث: 20240924
DOI: 10.1016/j.rbmo.2023.103729
PMID: 38367593
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6491
DOI:10.1016/j.rbmo.2023.103729