Genetically predicted retinal vascular occlusion in relation to cardiovascular diseases: A bidirectional two-sample Mendelian randomization analysis.

التفاصيل البيبلوغرافية
العنوان:	Genetically predicted retinal vascular occlusion in relation to cardiovascular diseases: A bidirectional two-sample Mendelian randomization analysis.
المؤلفون:	Zhang J; Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, The People's Republic of China., Pan Y; Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, The People's Republic of China., Yang H; Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, The People's Republic of China., Hu S; Wuhan Aier Eye Hospital of Wuhan University, Wuhan, The People's Republic of China., Zheng S; Department of Ophthalmology, PuAi Hospital, Anlu, The People's Republic of China., He T; Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, The People's Republic of China.
المصدر:	Annals of human genetics [Ann Hum Genet] 2024 Jul; Vol. 88 (4), pp. 336-348. Date of Electronic Publication: 2024 Feb 19.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0416661 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-1809 (Electronic) Linking ISSN: 00034800 NLM ISO Abbreviation: Ann Hum Genet Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2010-> : Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell
مواضيع طبية MeSH:	Mendelian Randomization Analysis* , Retinal Vein Occlusion/genetics , Cardiovascular Diseases/genetics , Genome-Wide Association Study* , Genetic Predisposition to Disease*, Humans ; Risk Factors ; Polymorphism, Single Nucleotide ; Retinal Artery Occlusion/genetics
مستخلص:	Introduction: Increasing evidence implicates retinal vascular occlusions as a susceptibility factor for cardiovascular diseases (CVDs), whereas inconsistent results on the relationship were reported in previous observational studies. This research using a bidirectional two-sample Mendelian randomization (MR) analysis aimed to investigate the potential association between genetically determined central/branch retinal artery and retinal vein occlusions (CRAO/BRAO/RVO) and the risk of CVD. Methods: Summary statistics of retinal vascular occlusions from the largest available genome-wide association study of European descent were used to investigate their relationship with CVDs, and vice versa. Primary analyses were conducted using the common inverse-variance weighted approach. Several complementary sensitivity analyses were performed to verify the reliability of our results. Results: Inverse variance weighted method showed suggestive effects of genetically determined RVO on ischemic stroke (IS) (odds ratio [OR] = 1.021, 95% confidence [CI] = 1.004-1.037, p = 0.012), a genetic liability to CRAO increased the risk of myocardial infarction (MI) (OR = 1.014, 95% CI = 1.006-1.023, p = 7.0 × 10-4). In addition, genetic predisposition to BRAO had a positive effect on stroke (OR = 1.008, 95% CI = 1.002-1.013, p = 0.011), IS (OR = 1.007, 95% CI = 1.001-1.014, p = 0.022), and cardioembolic stroke (CES) (OR = 1.018, 95% CI = 1.006-1.031, p = 0.004). The point estimates from sensitivity analyses were in the same direction. Reverse MR analyses found no significant evidence for the effect of CVDs on retinal vascular occlusions. Conclusion: Our MR study provides potential evidence that retinal vascular occlusions are causally linked to increased risk of CVDs including IS, MI, stroke, and CES. This supports the need for clinical CVD screening in individuals with retinal vascular occlusions. Further investigations are warranted to clarify the effects of CVDs on ocular comorbidities. (© 2024 University College London (UCL) and John Wiley & Sons Ltd.)
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معلومات مُعتمدة:	2042023kf0047 Fundamental Research Funds for Central Universities
فهرسة مساهمة:	Keywords: Mendelian randomization; cardiovascular diseases; epidemiology; retinal vascular occlusions
تواريخ الأحداث:	Date Created: 20240219 Date Completed: 20240611 Latest Revision: 20240611
رمز التحديث:	20240611
DOI:	10.1111/ahg.12552
PMID:	38369935
قاعدة البيانات:	MEDLINE

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تدمد:	1469-1809
DOI:	10.1111/ahg.12552