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Oligosaccharides from black ginseng innovatively prepared by low-temperature steam-heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap-1/Nrf2 pathway.

التفاصيل البيبلوغرافية
العنوان: Oligosaccharides from black ginseng innovatively prepared by low-temperature steam-heating process ameliorate cognitive impairment in Alzheimer's disease mice via the Keap-1/Nrf2 pathway.
المؤلفون: Xu W; College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China., Yu P; College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China., Shao S; The Public Experimental Center, Changchun University of Chinese Medicine, Changchun, China., Xie Z; The Public Experimental Center, Changchun University of Chinese Medicine, Changchun, China., Wu Y; The Public Experimental Center, Changchun University of Chinese Medicine, Changchun, China., Liu J; College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China., Xu T; Innovation Practice Center, Changchun University of Chinese Medicine, Changchun, China., Cai G; College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China., Yang H; The Public Experimental Center, Changchun University of Chinese Medicine, Changchun, China.
المصدر: Journal of the science of food and agriculture [J Sci Food Agric] 2024 Jul; Vol. 104 (9), pp. 5625-5638. Date of Electronic Publication: 2024 Mar 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
مواضيع طبية MeSH: Alzheimer Disease*/metabolism , Alzheimer Disease*/drug therapy , NF-E2-Related Factor 2*/metabolism , NF-E2-Related Factor 2*/genetics , Panax*/chemistry , Oligosaccharides*/chemistry , Oligosaccharides*/administration & dosage , Oligosaccharides*/pharmacology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Kelch-Like ECH-Associated Protein 1*/metabolism , Kelch-Like ECH-Associated Protein 1*/genetics , Plant Extracts*/chemistry , Plant Extracts*/administration & dosage , Plant Extracts*/pharmacology, Animals ; Mice ; Male ; Humans ; Steam ; Disease Models, Animal ; Gastrointestinal Microbiome/drug effects ; Oxidative Stress/drug effects ; Hot Temperature ; Superoxide Dismutase/metabolism ; Glutathione Peroxidase/metabolism
مستخلص: Background: Our objective in this study was to evaluate the effectiveness of oligosaccharides extracted from black ginseng (OSBG), innovatively prepared by a low-temperature steam-heating process, in the improvement of learning and memory impairment in mice, as well as the mechanism(s).
Results: Eight carbohydrates involving isomaltose and maltotetraose were detected in black gensing; monosaccharide residues including mannose and rhamnose were also discovered. OSBG-treated mice showed significant amelioration in recognition and spatial memory deficits compared to the scopolamine group. OSBG could decrease acetylcholinesterase activity in a tissue-dependent fashion but not in a dose-dependent manner. Furthermore, in contrast, OSBG administration resulted in significant upregulation superoxide dismutase, glutathione, glutathione peroxidase (GPx), and Kelch-like ECH-associated protein 1, downregulation of malondialdehyde and nuclear factor erythroid 2-related factor 2 in the tissues. Finally, at the genus level, we observed that the OSBG interventions increased the relative abundance of probiotics (e.g., Barnesiella, Staphylococcus, Clostridium_XlVb) and decreased pernicious bacteria such as Eisenbergiella and Intestinimonas, compared to the Alzheimer's disease mouse model group. Herein, our results demonstrate that OSBG restores the composition of the scopolamine-induced intestinal microbiota in mice, providing homeostasis of gut microbiota and providing evidence for microbiota-regulated therapeutic potential.
Conclusion: Our results showed for the first time a clear role for OSBG in improving scopolamine-induced memory impairment by inhibiting cholinergic dysfunction in a tissue-dependent manner. Additionally, OSBG administration relieved oxidative stress by activating the Keap-1/Nrf2 pathway and modulating the gut microbiota. Collectively, OSBG may be a promising target for neuroprotective antioxidants for improving memory and cognition in Alzheimer's disease patients. © 2024 Society of Chemical Industry.
(© 2024 Society of Chemical Industry.)
References: Joseph G, Bryan J, Tricia J, Scholz K and Jennifer W, 2016 Alzheimer's disease facts and figures. Alzheimers Dement 12:459–509 (2016).
Cummings J, Lee G, Zhong K, Fonseca J and Taghva K, Alzheimer's disease drug development pipeline: 2021. Alzheimers Dement (N Y) 7:e12179 (2021).
Taudorf L, Norgaard A, Waldemar G and Laursen TM, Mortality in dementia from 1996 to 2015: a national registry‐based cohort study. J Alzheimers Dis 79:289–300 (2021).
Thoe SE, Fauzi A, Tang YQ, Chamyuang S and Chia AYY, A review on advances of treatment modalities for Alzheimer's disease. Life Sci 276:119129 (2021).
Bortolami M, Pandolfi F, De VD, Carafa C, Messore A, Santo DR et al., New deferiprone derivatives as multi‐functional cholinesterase inhibitors: design, synthesis and in vitro evaluation. Eur J Med Chem 198:112350 (2020).
Yang HM, Chang‐Ki O, Haitham A, John SW, Sarah L, Emily S et al., Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S‐nitrosylation of C3. Sci Adv 50:eade0764 (2022).
Kim JH, He M, Kim MJ, Yang CY, Shin YS, Yokozawa T et al., Safflower (Carthamus tinctorius L.) seed attenuates memory impairment induced by scopolamine in mice via regulation of cholinergic dysfunction and oxidative stress. Food Funct 10:3650–3659 (2019).
Birks JS, Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 6:CD001190 (2006).
Ali TB, Schleret TR, Reilly BM, Chen WY and Abagyan R, Adverse effects of cholinesterase inhibitors in dementia, according to the pharmacovigilance databases of the United‐States and Canada. PloS One 10:e0144337 (2015).
Weller J and Budson A, Current understanding of Alzheimer's disease diagnosis and treatment. F1000Res 7:F1000 (2018).
Li X, Huang J and May JM, Ascorbic acid spares alpha‐tocopherol and decreases lipid peroxidation in neuronal cells. Biochem Biophys Res Commun 2003:656–661 (2003).
Gugliandolo A, Bramanti P and Mazzon E, Role of vitamin E in the treatment of Alzheimer's disease: evidence from animal models. Int J Mol Sci 18:2504 (2017).
Pandi‐Perumal SR, BaHammam AS, Brown GM, Spence DW, Bharti VK, Kaur C et al., Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotox Res 23:267–300 (2013).
Goozee KG, Shah TM, Sohrabi HR, Rainey‐Smith SR, Brown B, Verdile G et al., Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease. Br J Nutr 115:449–465 (2015).
Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF and Gibson GE, Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54:111–118 (2009).
Kim J, Kim SH, Lee DS, Lee DJ, Kim SH, Chung S et al., Effects of fermented ginseng on memory impairment and beta‐amyloid reduction in Alzheimer's disease experimental models. J Ginseng Res 37:100–107 (2013).
Cho IH, Effects of Panax ginseng in neurodegenerative diseases. J Ginseng Res 36:342–353 (2012).
Zhao ZL, Kim YW, Wu YY, Zhang J, Lee JH, Li XH et al., Korean red ginseng attenuates anxiety‐like behavior during ethanol withdrawal in rats. J Ginseng Res 38:256–263 (2014).
Jiao LL, Zhang XY, Li B, Liu Z, Wang MZ and Liu SY, Anti‐tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C.A. Meyer. Int J Biol Macromol 65:229–233 (2014).
Jiao L, Li B, Wang M, Liu Z, Zhang X and Liu S, Antioxidant activities of the oligosaccharides from the roots, flowers and leaves of Panax ginseng C.A. Meyer. Carbohydr Polym 106:293–298 (2014).
Wang Y, Jiang R, Li G, Chen Y, Luo H, Gao Y et al., Structural and enhanced memory activity studies of extracts from Panax ginseng root. Food Chem 119:969–973 (2010).
Xu T, Shen XF, Yu HL, Sun LL, Lin WL and Zhang CX, Water‐soluble ginseng oligosaccharides protect against scopolamine‐induced cognitive impairment by functioning as an antineuroinflammatory agent. J Ginseng Res 40:211–219 (2016).
Metwaly AM, Lianlian Z, Luqi H and Deqiang D, Black ginseng and its saponins: preparation, phytochemistry and pharmacological effects. Molecules 24:1856 (2019).
Lee MR, Begum S and Sung CK, Effect of red and black ginseng on cholinergic markers, presynaptic markers, and neurotrophins in the brain of aged mice. Food Sci Biotechnol 26:1743–1747 (2017).
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T et al., Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155:1451–1463 (2013).
Chen YJ, Fang LH, Chen S, Zhou HK, Fan YY, Lin L et al., Gut microbiome alterations precede cerebral amyloidosis and microglial pathology in a mouse model of Alzheimer's disease. Biomed Res Int 2020:8456596 (2020).
Tran SM and Mohajeri MH, The role of gut bacterial metabolites in brain development, aging and disease. Nutrients 13:732 (2021).
Nagpal J and Cryan JF, Microbiota‐brain interactions: moving toward mechanisms in model organisms. Neuron 2021:3930–3953 (2021).
Zhang TL, Han YR, Wang JY, Hou DR, Deng H, Deng YL et al., Comparative epidemiological investigation of Alzheimer's disease and colorectal cancer: the possible role of gastrointestinal conditions in the pathogenesis of AD. Front Aging Neurosci 10:176 (2018).
Jia QJ, Wang L, Zhang XN, Ding YJ, Li H, Yang YX et al., Prevention and treatment of chronic heart failure through traditional Chinese medicine: Role of the gut microbiota. Pharmacol Res 151:104552 (2020).
Feng W, Ao H, Peng C and Yan D, Gut microbiota, a new frontier to understand traditional Chinese medicines. Pharmacol Res 142:176–191 (2019).
Shao SM, Wang YH, Xie ZY, Xu RY, Wan XL, Wang EP et al., 96‐well plate format in conjunction with ultra‐high‐performance liquid chromatography coupled to orbitrap mass spectrometry for high‐throughput screening protein binders from ginseng. J Pharm Biomed Anal 209:114498 (2022).
Yang XB, Zhao Y, Wang QW, Wang HF and Mei QB, Analysis of the monosaccharide components in Angelica polysaccharides by high performance liquid chromatography. Anal Sci 21:1177–1780 (2005).
Kim SK, Kwon DA, Kim YS, Lee HS, Kim HK and Kim WK, Standardized extract (HemoHIM) protects against scopolamine‐induced amnesia in a murine model. Evid Based Complement Alternat Med 2021:8884243 (2021).
Xiao J, Li SY, Sui Y, Wu Q, Li XP, Xie BJ et al., Lactobacillus casei‐01 facilitates the ameliorative effects of proanthocyanidins extracted from lotus seedpod on learning and memory impairment in scopolamine‐induced amnesia mice. PloS One 9:e112773 (2014).
Lopez N, Tormo C, De BI, Llinares I and Alom J, Oxidative stress in Alzheimer's disease and mild cognitive impairment with high sensitivity and specificity. J Alzheimers Dis 33:823–829 (2013).
Beatty WW, Butters N and Janowsky DS, Patterns of memory failure after scopolamine treatment: implications for cholinergic hypotheses of dementia. Behav Neural Biol 45:196–211 (1986).
Drevets WC, Bhattacharya A and Furey ML, The antidepressant efficacy of the muscarinic antagonist scopolamine: past findings and future directions. Adv Pharmacol 89:357–386 (2020).
Bhuvanendran S, Kumari Y, Othman I and Shaikh MF, Amelioration of cognitive deficit by embelin in a scopolamine‐induced Alzheimer's disease‐like condition in a rat model. Front Pharmacol 9:665 (2018).
Tonnies E and Trushina E, Oxidative stress, synaptic dysfunction, and Alzheimer's disease. J Alzheimers Dis 57:1105–1121 (2017).
Ferreira‐Vieira TH, Isabella MG, Flavia RS and Fabiola MR, Alzheimer's disease: targeting the cholinergic system. Curr Neuropharmacol 14:101–115 (2016).
Budzynska B, Boguszewska‐Czubara A, Kruk‐Slomka M, Skalicka‐Wozniak K, Michalak A, Musik I et al., Effects of imperatorin on scopolamine‐induced cognitive impairment and oxidative stress in mice. Psychopharmacology (Berl) 232:931–942 (2015).
Lian WW, Fang JS, Xu LJ, Zhou W, Kang D, Xiong WD et al., DL0410 ameliorates memory and cognitive impairments induced by scopolamine via increasing cholinergic neurotransmission in mice. Molecules 22:410 (2017).
Chen WN and Yeong KY, Scopolamine, a toxin‐induced experimental model, used for research in Alzheimer's disease. CNS Neurol Disord Drug Targets 19:85–93 (2020).
Parfitt GM, Campos RC, Barbosa AK, Koth AP and Barros DM, Participation of hippocampal cholinergic system in memory persistence for inhibitory avoidance in rats. Neurobiol Learn Mem 97:183–188 (2012).
Bellingham MC, A review of the neural mechanisms of action and clinical efficiency of riluzole in treating amyotrophic lateral sclerosis: what have we learned in the last decade? CNS Neurosci Ther 17:4–31 (2011).
Lee HJ, Lim SM, Ko DB, Jeong JJ, Hwang YH and Kim DH, Soyasapogenol B and genistein attenuate lipopolysaccharide‐induced memory impairment in mice by the modulation of NF‐kappa B‐mediated BDNF expression. J Agric Food Chem 65:6877–6885 (2017).
Muller SG, Jardim NS, Quines CB and Nogueira CW, Diphenyl diselenide regulates Nrf2/Keap‐1 signaling pathway and counteracts hepatic oxidative stress induced by bisphenol a in male mice. Environ Res 164:280–287 (2018).
Wang JM, Jiang C, Zhang K, Lan X, Chen XM, Zang WD et al., Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway. Free Radic Biol Med 131:345–355 (2019).
Yu H, Zhang J, Ji Q, Yu K, Wang P, Song M et al., Melatonin alleviates aluminium chloride‐induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway. Ecotoxicol Environ Saf 173:131–141 (2019).
Suzuki T and Yamamoto M, Molecular basis of the Keap1‐Nrf2 system. Free Radic Biol Med 88:93–100 (2015).
Kensler TW, Wakabayashi N and Biswal S, Cell survival responses to environmental stresses via the Keap1‐Nrf2‐ARE pathway. Annu Rev Pharmacol Toxicol 47:89–116 (2007).
Magesh S, Chen Y and Hu L, Small molecule modulators of Keap1‐Nrf2‐ARE pathway as potential preventive and therapeutic agents. Med Res Rev 32:687–726 (2012).
Deshmukh P, Unni S, Krishnappa G and Padmanabhan B, The Keap1‐Nrf2 pathway: promising therapeutic target to counteract ROS‐mediated damage in cancers and neurodegenerative diseases. Biophys Rev 9:41–56 (2017).
Vogt NM, Kerby RL, Dill‐Mc Farland KA, Harding SJ, Merluzzi AP, Johnson SC et al., Gut microbiome alterations in Alzheimer's disease. Sci Rep 7:13537 (2017).
Parseus A, Sommer N, Sommer F, Caesar R, Molinaro A, Stahlman M et al., Microbiota‐induced obesity requires farnesoid X receptor. Gut 66:429–437 (2017).
Bonaz B, Bazin T and Pellissier S, The vagus nerve at the interface of the microbiota‐gut‐brain axis. Front Neurosci 12:49 (2018).
Tse JKY, Gut microbiota, nitric oxide, and microglia as prerequisites for neurodegenerative disorders. ACS Chem Nerosci 8:1438–1447 (2017).
Jones RM, Mercante JW and Neish AS, Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications. Curr Med Chem 19:1519–1529 (2012).
معلومات مُعتمدة: 20230203157SF Technology Development Planning Project of Jilin Province; 20220204077YY Technology Development Planning Project of Jilin Province; 20220508086RC Technology Development Planning Project of Jilin Province; 20210204035YY Technology Development Planning Project of Jilin Province; The key technologies and cognitive enhancement mechanisms of ginseng and American ginseng processed at low temperatures
فهرسة مساهمة: Keywords: Alzheimer's disease mice; black ginseng; gut microbiota; low‐temperature steam‐heating process; neuroprotective antioxidants; oligosaccharides
المشرفين على المادة: 0 (NF-E2-Related Factor 2)
0 (Oligosaccharides)
0 (Kelch-Like ECH-Associated Protein 1)
0 (Plant Extracts)
0 (Steam)
0 (Keap1 protein, mouse)
0 (Nfe2l2 protein, mouse)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.11.1.9 (Glutathione Peroxidase)
تواريخ الأحداث: Date Created: 20240219 Date Completed: 20240614 Latest Revision: 20240614
رمز التحديث: 20240614
DOI: 10.1002/jsfa.13394
PMID: 38372395
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0010
DOI:10.1002/jsfa.13394