دورية أكاديمية
Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis.
| العنوان: | Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis. |
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| المؤلفون: | Guillen-Guio B; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; Joint first authors., Paynton ML; Department of Population Health Sciences, University of Leicester, Leicester, UK.; Joint first authors., Allen RJ; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Chin DPW; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Donoghue LJ; Genentech, San Francisco, CA, USA., Stockwell A; Genentech, San Francisco, CA, USA., Leavy OC; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Hernandez-Beeftink T; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Reynolds C; National Heart & Lung Institute, Imperial College London, London, UK., Cullinan P; National Heart & Lung Institute, Imperial College London, London, UK., Martinez F; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Booth HL; University College Hospital, University College London, London, UK., Fahy WA; GlaxoSmithKline, London, UK., Hall IP; School of Medicine, University of Nottingham, Nottingham, UK.; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK., Hart SP; Hull York Medical School, University of Hull, Hull, UK., Hill MR; MRC Population Health Unit, University of Oxford, Oxford, UK., Hirani N; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Hubbard RB; School of Medicine, University of Nottingham, Nottingham, UK.; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK., McAnulty RJ; Division of Medicine, University College London, London, UK., Millar AB; Bristol Medical School, University of Bristol, Bristol, UK., Navaratnam V; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.; National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.; Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, QLD, Australia., Oballa E; GlaxoSmithKline, London, UK., Parfrey H; Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK., Saini G; School of Medicine, University of Nottingham, Nottingham, UK., Sayers I; Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham, UK., Tobin MD; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK., Whyte MKB; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK., Adegunsoye A; Department of Medicine, University of Chicago, Chicago, IL, USA., Kaminski N; Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Ma SF; Department of Medicine, University of Virginia, Charlottesville, VA, USA., Strek ME; Department of Medicine, University of Chicago, Chicago, IL, USA., Zhang Y; Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Fingerlin TE; Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA., Molina-Molina M; Servei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain.; Campus de Bellvitge, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Neighbors M; Genentech, San Francisco, CA, USA., Sheng XR; Genentech, San Francisco, CA, USA., Oldham JM; Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USA., Maher TM; National Heart and Lung Institute, Imperial College London, London, UK.; Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, USA., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Flores C; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.; Genomics Division, Instituto Tecnologico y de Energias Renovables, Santa Cruz de Tenerife, Spain.; Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain., Noth I; Department of Medicine, University of Virginia, Charlottesville, VA, USA., Schwartz DA; Department of Medicine, University of Colorado, Anscuhtz, CO, USA., Yaspan BL; Genentech, San Francisco, CA, USA., Jenkins RG; National Heart and Lung Institute, Imperial College London, London, UK., Wain LV; Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Leicester, UK.; Joint senior authors., Hollox EJ; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.; Joint senior authors. |
| المصدر: | ERJ open research [ERJ Open Res] 2024 Feb 19; Vol. 10 (1). Date of Electronic Publication: 2024 Feb 19 (Print Publication: 2024). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: European Respiratory Society Country of Publication: England NLM ID: 101671641 Publication Model: eCollection Cited Medium: Print ISSN: 2312-0541 (Print) Linking ISSN: 23120541 NLM ISO Abbreviation: ERJ Open Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Sheffield : European Respiratory Society, [2015]- |
| مستخلص: | Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and a prior association of the HLA-DQB1 gene with idiopathic fibrotic interstitial pneumonia (including IPF) has been reported. Owing to the important role that the human leukocyte antigen (HLA) region plays in the immune response, here we evaluated if HLA genetic variation was associated specifically with IPF risk. Methods: We performed a meta-analysis of associations of the HLA region with IPF risk in individuals of European ancestry from seven independent case-control studies of IPF (comprising 5159 cases and 27 459 controls, including a prior study of fibrotic interstitial pneumonia). Single nucleotide polymorphisms, classical HLA alleles and amino acids were analysed and signals meeting a region-wide association threshold of p<4.5×10 -4 and a posterior probability of replication >90% were considered significant. We sought to replicate the previously reported HLA-DQB1 association in the subset of studies independent of the original report. Results: The meta-analysis of all seven studies identified four significant independent single nucleotide polymorphisms associated with IPF risk. However, none met the posterior probability for replication criterion. The HLA-DQB1 association was not replicated in the independent IPF studies. Conclusion: Variation in the HLA region was not consistently associated with risk in studies of IPF. However, this does not preclude the possibility that other genomic regions linked to the immune response may be involved in the aetiology of IPF. Competing Interests: Conflict of interest: L.J. Donoghue, A. Stockwell, M. Neighbours, X.R. Sheng and B.L. Yaspan are full-time employees of Genentech; A. Stockwell, M. Neighbours, X.R. Sheng and B.L. Yaspan hold stock options in Roche. J.M. Oldham reports personal fees from Boehringer Ingelheim, Genentech, United Therapeutics, AmMax Bio and Lupin Pharmaceuticals outside the submitted work. D.A. Schwartz is the founder and chief scientific officer of Eleven P15, a company focused on the early detection and treatment of pulmonary fibrosis. R.G. Jenkins reports honoraria from Chiesi, Roche, PatientMPower, AstraZeneca, GlaxoSmithKline and Boehringer Ingelheim, and consulting fees from Bristol Myers Squibb, Daewoong, Veracyte, Resolution Therapeutics, RedX, Pliant and Chiesi. L.V. Wain reports research funding from GlaxoSmithKline, Roche and Orion Pharma, and consultancy for GlaxoSmithKline and Galapagos, outside of the submitted work. S.P. Hart and P.L. Molyneaux are associate editors of this journal. The other authors declare no competing interests. (Copyright ©The authors 2024.) |
| التعليقات: | Update of: medRxiv. 2023 Jul 24:2023.07.20.23292940. doi: 10.1101/2023.07.20.23292940. (PMID: 37546732) |
| References: | Am J Clin Pathol. 2003 Apr;119(4):556-67. (PMID: 12710128) Intensive Care Med. 2022 Dec;48(12):1803-1806. (PMID: 36074167) Occup Environ Med. 2023 Feb;80(2):97-103. (PMID: 36635100) Am J Respir Crit Care Med. 2023 Apr 1;207(7):941-944. (PMID: 36603154) Gene. 2019 Feb 5;684:118-123. (PMID: 30366082) Chest. 2023 Feb;163(2):362-365. (PMID: 36029835) Nat Commun. 2021 Mar 30;12(1):1964. (PMID: 33785739) Nat Genet. 2021 Oct;53(10):1415-1424. (PMID: 34594039) Nat Rev Immunol. 2018 May;18(5):325-339. (PMID: 29292391) Am J Respir Crit Care Med. 2023 Jun 1;207(11):1515-1524. (PMID: 36780644) Genome Res. 2009 Sep;19(9):1655-64. (PMID: 19648217) Nature. 2021 Feb;590(7845):290-299. (PMID: 33568819) Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):646-64. (PMID: 10673212) Nat Genet. 2016 Oct;48(10):1284-1287. (PMID: 27571263) Gigascience. 2015 Feb 25;4:7. (PMID: 25722852) Nat Genet. 2012 Mar 18;44(4):369-75, S1-3. (PMID: 22426310) Nat Genet. 2013 Jun;45(6):613-20. (PMID: 23583980) Lancet Respir Med. 2017 Nov;5(11):869-880. (PMID: 29066090) Yonsei Med J. 2007 Feb 28;48(1):11-23. (PMID: 17326240) PLoS One. 2013 Jun 06;8(6):e64683. (PMID: 23762245) Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304. (PMID: 11790668) Bioinformatics. 2010 Sep 1;26(17):2190-1. (PMID: 20616382) Pulm Med. 2011;2011:240805. (PMID: 21660226) Chest. 2020 May;157(5):1175-1187. (PMID: 31730835) JAMA. 2021 May 11;325(18):1841-1851. (PMID: 33974018) Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824. (PMID: 21471066) Lancet Respir Med. 2023 Jan;11(1):65-73. (PMID: 35985358) Cell Genom. 2022 Oct 12;2(10):100181. (PMID: 36777997) Hum Mutat. 2017 Jul;38(7):788-797. (PMID: 28419628) Am J Respir Crit Care Med. 2018 Sep 1;198(5):e44-e68. (PMID: 30168753) Hum Immunol. 2017 Mar;78(3):239-241. (PMID: 28317600) Am J Respir Crit Care Med. 2015 Jul 15;192(2):e3-19. (PMID: 26177183) Br J Pharmacol. 2011 May;163(1):96-105. (PMID: 21232051) PLoS One. 2011 Feb 23;6(2):e14715. (PMID: 21373184) Thorax. 2022 Aug;77(8):829-833. (PMID: 35688625) BMC Genet. 2016 Jun 07;17(1):74. (PMID: 27266705) Clin Med Insights Circ Respir Pulm Med. 2016 Dec 08;9(Suppl 1):179-185. (PMID: 27980445) Lancet Respir Med. 2013 Jun;1(4):309-317. (PMID: 24429156) PLoS Comput Biol. 2021 Jul 6;17(7):e1009131. (PMID: 34228721) Lancet Respir Med. 2018 Aug;6(8):603-614. (PMID: 29891356) BMC Bioinformatics. 2008 Dec 16;9:540. (PMID: 19087329) J Inflamm Res. 2021 Jan 05;13:1305-1318. (PMID: 33447070) Nat Genet. 2021 Oct;53(10):1504-1516. (PMID: 34611364) Am J Respir Crit Care Med. 2020 Mar 1;201(5):564-574. (PMID: 31710517) |
| معلومات مُعتمدة: | UL1 TR001863 United States TR NCATS NIH HHS; UH3 HL151865 United States HL NHLBI NIH HHS; I01 BX005295 United States BX BLRD VA; R56 HL158935 United States HL NHLBI NIH HHS; United Kingdom WT_ Wellcome Trust; CDA 13-017 United States HX HSRD VA; R01 HL169166 United States HL NHLBI NIH HHS; P01 HL162607 United States HL NHLBI NIH HHS; K23 HL138190 United States HL NHLBI NIH HHS |
| تواريخ الأحداث: | Date Created: 20240220 Latest Revision: 20240806 |
| رمز التحديث: | 20240806 |
| مُعرف محوري في PubMed: | PMC10875457 |
| DOI: | 10.1183/23120541.00553-2023 |
| PMID: | 38375425 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2312-0541 |
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| DOI: | 10.1183/23120541.00553-2023 |