دورية أكاديمية
Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study).
| العنوان: | Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study). |
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| المؤلفون: | Cechin L; King's College Hospital NHS Foundation Trust, London, UK., Dominguez-Dominguez L; King's College Hospital NHS Foundation Trust, London, UK., Campbell L; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK., Hamzah L; St George's Hospital NHS Foundation Trust, London, UK., Fox J; King's College London, London, UK.; Guys and St Thomas's NHS Foundation Trust, London, UK., Vincent RP; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK.; Synnovis Analytics, London, UK., Dimitriadis GK; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK., Goff L; Leicester General Hospital, University of Leicester, Leicester, UK., Post FA; King's College Hospital NHS Foundation Trust, London, UK.; King's College London, London, UK. |
| المصدر: | International journal of STD & AIDS [Int J STD AIDS] 2024 Jun; Vol. 35 (7), pp. 521-526. Date of Electronic Publication: 2024 Feb 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dec. 2012- : London : Sage Original Publication: London, U.K. : Royal Society of Medicine Services, c1990- |
| مواضيع طبية MeSH: | HIV Infections*/ethnology , Metabolic Syndrome*/ethnology , Metabolic Syndrome*/epidemiology , Metabolic Syndrome*/diagnosis , Waist Circumference* , Black People*/statistics & numerical data , Glycated Hemoglobin*/analysis, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Adult ; Insulin Resistance ; London/epidemiology ; Caribbean Region/ethnology ; Blood Glucose/analysis ; Triglycerides/blood ; ROC Curve ; Risk Factors ; Cardiometabolic Risk Factors ; Cholesterol/blood |
| مستخلص: | Background: There are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV. Methods: Cross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver operating characteristic (ROC) curves to describe the relationship between WC and cardiometabolic parameters including triglycerides, cholesterol, glucose, glycated haemoglobin (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR), and to identify optimal WC cut-offs for each of these outcomes. Results: We included 383 participants (55% female, median age 52 years) with generally well controlled HIV. Female and male participants had similar WC (median 98 vs. 97 cm, p = .16). Generally weak correlations (r 2 < 0.2) between WC and other cardiometabolic parameters were observed, with low (<0.7) areas under the ROC curves. The optimal WC cut-offs for constituents of the metabolic syndrome, HbA1c and HOMA-IR ranged from 92 to 101 cm in women and 89-98 cm in men, respectively; these cut-offs had variable sensitivity (52%-100%) and generally poor specificity (28%-72%). Conclusions: In this cohort of Black people with HIV, WC cut-offs for cardiometabolic risk factors in male participants were in line with the recommended value of 94 cm while in female participants they vastly exceeded the recommended 80 cm for white women. Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: LC, LD-D, LC, LH, JF and LG declared no competing interests. RPV reports grants and honoraria from Novo Nordisk, AstraZeneca, and Amarin Limited outside of this work. GKD reports research grants from Novo Nordisk and Diabetes Digital Media, and personal fees from Novo Nordisk, Rhythm Pharmaceuticals, Johnson&Johnson/Ethicon and Medtronic outside of this work. FAP reports grants and personal fees and non-financial support from Gilead, grants and personal fees and non-financial support from ViiV, grants and personal fees and non-financial support from MSD outside of the present study. |
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| فهرسة مساهمة: | Keywords: HIV; Metabolic syndrome; black ethnicity; insulin resistance; waist circumference |
| المشرفين على المادة: | 0 (Glycated Hemoglobin) 0 (Blood Glucose) 0 (Triglycerides) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240606 Latest Revision: 20240609 |
| رمز التحديث: | 20240609 |
| مُعرف محوري في PubMed: | PMC11157977 |
| DOI: | 10.1177/09564624241233036 |
| PMID: | 38377277 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-1052 |
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| DOI: | 10.1177/09564624241233036 |