دورية أكاديمية
Pd(II)-Catalyzed β-C(sp 3 )-H Alkynylation of Alanine in Di- and Tripeptides with Asn as an Endogenous Directing Group.
| العنوان: | Pd(II)-Catalyzed β-C(sp 3 )-H Alkynylation of Alanine in Di- and Tripeptides with Asn as an Endogenous Directing Group. |
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| المؤلفون: | Ding XX; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China., Ren BQ; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China., Li BT; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Pang ZJ; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Xu YJ; College of Chemistry and Material Science, Sichuan Normal University, Chengdu, Sichuan 610066, China., Dong L; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China. |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2024 Mar 01; Vol. 89 (5), pp. 3390-3402. Date of Electronic Publication: 2024 Feb 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Alanine* , Alkynes*, Glycopeptides ; Catalysis |
| مستخلص: | The introduction of alkyne moieties into peptides remains in demand as it represents a promising approach for further structural diversification of peptides. Herein, we describe the Pd(II)-catalyzed C(sp 3 )-H alkynylation of Ala-Asn-embedded di- and tripeptides using Asn as the endogenous lead group. In addition, a key building block for the glycopeptide Tyc4PG-14 and Tyc4PG-15 was produced by our methodology. |
| المشرفين على المادة: | OF5P57N2ZX (Alanine) 0 (Alkynes) 0 (Glycopeptides) |
| تواريخ الأحداث: | Date Created: 20240220 Date Completed: 20240304 Latest Revision: 20240408 |
| رمز التحديث: | 20240408 |
| DOI: | 10.1021/acs.joc.3c02823 |
| PMID: | 38377557 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6904 |
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| DOI: | 10.1021/acs.joc.3c02823 |