دورية أكاديمية
Patient Sex Mediates the Influence of Patient Age on Superior Canal Dehiscence Repair Outcome.
العنوان: | Patient Sex Mediates the Influence of Patient Age on Superior Canal Dehiscence Repair Outcome. |
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المؤلفون: | Yang HH; Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, California, U.S.A., Yang I; Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, California, U.S.A., Gopen QS; Department of Head and Neck Surgery, David Geffen School of Medicine at University of California, Los Angeles, California, U.S.A. |
المصدر: | The Laryngoscope [Laryngoscope] 2024 Jul; Vol. 134 (7), pp. 3363-3370. Date of Electronic Publication: 2024 Feb 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8607378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-4995 (Electronic) Linking ISSN: 0023852X NLM ISO Abbreviation: Laryngoscope Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2009- >: Philadelphia, PA : Wiley-Blackwell Original Publication: St. Louis, Mo. : [s.n., 1896- |
مواضيع طبية MeSH: | Semicircular Canal Dehiscence*/surgery, Humans ; Female ; Male ; Middle Aged ; Sex Factors ; Age Factors ; Treatment Outcome ; Adult ; Retrospective Studies ; Aged ; Otologic Surgical Procedures/methods ; Otologic Surgical Procedures/adverse effects ; Cohort Studies |
مستخلص: | Objective: To investigate the independent and interactive effects of patient age and sex on superior canal dehiscence (SCD) repair outcomes. Methods: This was a cohort study of consecutive SCD repairs via the middle fossa approach at an institution between 2011 and 2022. We constructed multivariable regression models assessing surgical outcomes with age and sex as the primary predictors. Models controlled for surgery duration, follow-up duration, and relevant surgical and medical history. Subsequently, we repeated each model with the incorporation of an interaction term between patient age and sex. Results: Among 402 repairs, average age was 50 years, and 63% of cases were females. There was a significant interaction between patient age and sex with respect to symptom resolution score (SRS) (adj. β 0.80, 95% C.I. 0.04-1.56). Older age was associated with lower SRS among females (-0.84, -1.29 to -0.39 point per year) but not significantly associated with SRS among males (0.04, -0.65 to 0.56 point per year). Furthermore, older age independently predicted a greater magnitude of increase in air conduction at 8000 Hz following surgery regardless of sex (adj. β 2.1, 0.2-4.0 dB per 10-year increase). Conclusions: This is the first study on the interactive effect between patient age and sex with respect to SCD repair outcomes. Older age predicted poorer symptomatic response among female patients but did not predict symptomatic response among male patients. Furthermore, older age predicted more severe high-frequency hearing loss following SCD repairs among both female and male patients. Level of Evidence: 3 Laryngoscope, 134:3363-3370, 2024. (© 2024 The American Laryngological, Rhinological and Otological Society, Inc.) |
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فهرسة مساهمة: | Keywords: age; middle cranial fossa approach; sex; superior canal dehiscence |
تواريخ الأحداث: | Date Created: 20240221 Date Completed: 20240617 Latest Revision: 20240617 |
رمز التحديث: | 20240617 |
DOI: | 10.1002/lary.31356 |
PMID: | 38381092 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1531-4995 |
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DOI: | 10.1002/lary.31356 |