دورية أكاديمية
أعرض في EDS

Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging.

التفاصيل البيبلوغرافية
العنوان: Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging.
المؤلفون: Singh S; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA., Giron LB; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA., Shaikh MW; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA., Shankaran S; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA.; Department of Medicine, Rush University, Chicago, IL, USA., Engen PA; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA., Bogin ZR; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA., Bambi SA; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA., Goldman AR; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA., Azevedo JLLC; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA., Orgaz L; Life Length, Madrid, Spain., de Pedro N; Life Length, Madrid, Spain., González P; Life Length, Madrid, Spain., Giera M; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Verhoeven A; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Sánchez-López E; Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands., Pandrea I; University of Pittsburgh, Pittsburgh, PA, USA., Kannan T; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA., Tanes CE; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Bittinger K; Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Landay AL; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA.; Department of Medicine, Rush University, Chicago, IL, USA., Corley MJ; Weill Cornell Medicine, New York, NY, USA., Keshavarzian A; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University, Chicago, IL, USA.; Department of Medicine, Rush University, Chicago, IL, USA., Abdel-Mohsen M; Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA. mmohsen@Wistar.org.
المصدر: Microbiome [Microbiome] 2024 Feb 22; Vol. 12 (1), pp. 31. Date of Electronic Publication: 2024 Feb 22.
نوع المنشور: Video-Audio Media; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London: BioMed Central, 2013-
مواضيع طبية MeSH: HIV Infections*/drug therapy , Gastrointestinal Microbiome*/genetics, Humans ; Female ; Male ; Dysbiosis/microbiology ; Intestines/microbiology ; Aging ; Bacteria/genetics ; Inflammation/microbiology ; Anti-Inflammatory Agents
مستخلص: Background: People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial dysbiosis and translocation, which may lead to non-AIDS-related aging-associated comorbidities. The extent to which living with HIV - influenced by the infection itself, ART usage, sexual orientation, or other associated factors - affects the biological age of the intestines is unclear. Furthermore, the role of microbial dysbiosis and translocation in the biological aging of PLWH remains to be elucidated. To investigate these uncertainties, we used a systems biology approach, analyzing colon and ileal biopsies, blood samples, and stool specimens from PLWH on ART and people living without HIV (PLWoH) as controls.
Results: PLWH exhibit accelerated biological aging in the colon, ileum, and blood, as measured by various epigenetic aging clocks, compared to PLWoH. Investigating the relationship between microbial translocation and biological aging, PLWH had decreased levels of tight junction proteins in the intestines, along with increased microbial translocation. This intestinal permeability correlated with faster biological aging and increased inflammation. When investigating the relationship between microbial dysbiosis and biological aging, the intestines of PLWH had higher abundance of specific pro-inflammatory bacteria, such as Catenibacterium and Prevotella. These bacteria correlated with accelerated biological aging. Conversely, the intestines of PLWH had lower abundance of bacteria known for producing the anti-inflammatory short-chain fatty acids, such as Subdoligranulum and Erysipelotrichaceae, and these bacteria were associated with slower biological aging. Correlation networks revealed significant links between specific microbial genera in the colon and ileum (but not in feces), increased aging, a rise in pro-inflammatory microbe-related metabolites (e.g., those in the tryptophan metabolism pathway), and a decrease in anti-inflammatory metabolites like hippuric acid.
Conclusions: We identified specific microbial compositions and microbiota-related metabolic pathways that are intertwined with intestinal and systemic biological aging. This microbial signature of biological aging is likely reflecting various factors including the HIV infection itself, ART usage, sexual orientation, and other aspects associated with living with HIV. A deeper understanding of the mechanisms underlying these connections could offer potential strategies to mitigate accelerated aging and its associated health complications. Video Abstract.
(© 2024. The Author(s).)
التعليقات: Update of: Res Sq. 2023 Oct 30:rs.3.rs-3492242. doi: 10.21203/rs.3.rs-3492242/v1. (PMID: 37961645)
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معلومات مُعتمدة: R01 MH134391 United States MH NIMH NIH HHS; CA010815 United States NH NIH HHS; R01 AI165079 United States AI NIAID NIH HHS; R01 DK123733 United States NH NIH HHS; R01 HL123096 United States HL NHLBI NIH HHS; R01 DK123733 United States DK NIDDK NIH HHS; R01 HL160392 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: Aging clocks; Biological aging; Gut; HIV; Intestines; Metabolome; Microbiome
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
تواريخ الأحداث: Date Created: 20240221 Date Completed: 20240223 Latest Revision: 20240716
رمز التحديث: 20240716
مُعرف محوري في PubMed: PMC10882811
DOI: 10.1186/s40168-024-01758-4
PMID: 38383483
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-2618
DOI:10.1186/s40168-024-01758-4