دورية أكاديمية
Effects of bovine whey protein on exercise-induced gut permeability in healthy adults: a randomised controlled trial.
| العنوان: | Effects of bovine whey protein on exercise-induced gut permeability in healthy adults: a randomised controlled trial. |
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| المؤلفون: | Ulluwishewa D; AgResearch, Te Ohu Rangahau Kai, Palmerston North, New Zealand. dulantha.ulluwishewa@agresearch.co.nz., Nicholls G; School of Sport, Exercise and Nutrition, Massey University, Palmerston North, New Zealand., Henderson H; AgResearch, Ruakura Research Centre, Hamilton, New Zealand., Bernstein D; AgResearch, Te Ohu Rangahau Kai, Palmerston North, New Zealand., Fraser K; AgResearch, Te Ohu Rangahau Kai, Palmerston North, New Zealand., Barnett MPG; AgResearch, Te Ohu Rangahau Kai, Palmerston North, New Zealand.; Riddet Institute, Palmerston North, New Zealand., Barnes MJ; School of Sport, Exercise and Nutrition, Massey University, Palmerston North, New Zealand. |
| المصدر: | European journal of applied physiology [Eur J Appl Physiol] 2024 Jul; Vol. 124 (7), pp. 2045-2056. Date of Electronic Publication: 2024 Feb 22. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 100954790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-6327 (Electronic) Linking ISSN: 14396319 NLM ISO Abbreviation: Eur J Appl Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c2000- |
| مواضيع طبية MeSH: | Whey Proteins*/pharmacology , Whey Proteins*/administration & dosage , Exercise*/physiology , Permeability*/drug effects, Humans ; Male ; Adult ; Female ; Animals ; Double-Blind Method ; Middle Aged ; Young Adult ; Lactulose/urine ; Lactulose/pharmacology ; Cross-Over Studies ; Adolescent ; Cattle ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/drug effects ; Rhamnose/pharmacology ; Mannitol/pharmacology |
| مستخلص: | Purpose: Intestinal permeability is a critical component of gut barrier function. Barrier dysfunction can be triggered by certain stressors such as exercise, and if left unmanaged can lead to local and systemic disorders. The aim of this study was to investigate the effects of a specific whey protein fraction in alleviating exercise-induced gut permeability as assessed by recovery of lactulose/rhamnose (L/R) and lactulose/mannitol (L/M) urinary probes. Methods: Eight males and eight females (aged 18-50) completed two arms of a double-blind, placebo-controlled, crossover study. For each arm participants performed two baseline intestinal permeability assessments, following which they consumed the treatment (2 g/day of milk powder containing 200 mg of whey protein) or placebo (2 g/day of milk powder) for 14 days, before performing a post-exercise permeability assessment. The exercise protocol involved a 20-min run at 80% of maximal oxygen uptake on a 1% incline. Results: Mixed model analysis revealed an increase in L/R (23%; P < 0.001) and L/M (20%; P < 0.01) recovery following exercise. However, there was no treatment or treatment × exercise effect. Conclusion: The exercise protocol utilised in our study induces gut permeability. However, consuming whey protein, at the dose and timing prescribed, is not able to mitigate this effect. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | HVN 1940 High-Value Nutrition National Science Contestable Fund |
| فهرسة مساهمة: | Keywords: Dairy protein; Exercise; Intestinal barrier |
| المشرفين على المادة: | 0 (Whey Proteins) 4618-18-2 (Lactulose) QN34XC755A (Rhamnose) 3OWL53L36A (Mannitol) |
| تواريخ الأحداث: | Date Created: 20240222 Date Completed: 20240625 Latest Revision: 20240827 |
| رمز التحديث: | 20240828 |
| مُعرف محوري في PubMed: | PMC11199293 |
| DOI: | 10.1007/s00421-024-05423-4 |
| PMID: | 38386104 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1439-6327 |
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| DOI: | 10.1007/s00421-024-05423-4 |