دورية أكاديمية
Estrogenic Prenylated Flavonoids in Sophora flavescens .
| العنوان: | Estrogenic Prenylated Flavonoids in Sophora flavescens . |
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| المؤلفون: | Nishi K; Faculty of Life Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan., Imamura I; Faculty of Life Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan., Hoashi K; Faculty of Life Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan., Kiyama R; Faculty of Life Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan., Mitsuiki S; Faculty of Life Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan. |
| المصدر: | Genes [Genes (Basel)] 2024 Feb 04; Vol. 15 (2). Date of Electronic Publication: 2024 Feb 04. |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel : MDPI |
| مواضيع طبية MeSH: | Sophora* , Plants, Medicinal*, Sophora flavescens ; Flavonoids/pharmacology ; Plant Extracts/pharmacology ; Estrone |
| مستخلص: | Sophora flavescens is a medicinal herb distributed widely in Japan and it has been used to treat various diseases and symptoms. To explore its pharmacological use, we examined the estrogenic activity of four prenylated flavonoids, namely kurarinone, kushenols A and I, and sophoraflavanone G, which are characterized by the lavandulyl group at position 8 of ring A, but have variations in the hydroxyl group at positions 3 (ring C), 5 (ring A) and 4' (ring B). These prenylated flavonoids were examined via cell proliferation assays using sulforhodamine B, Western blotting, and RT-PCR, corresponding to cell, protein, and transcription assays, respectively, based on estrogen action mechanisms. All the assays employed here found weak but clear estrogenic activities for the prenylated flavonoids examined. Furthermore, the activities were inhibited by an estrogen receptor antagonist, suggesting that the activities were likely being mediated by the estrogen receptors. However, there were differences in the activity, attributable to the hydroxyl group at position 4', which is absent in kushenol A. While the estrogenic activity of kurarinone and sophoraflavanone G has been reported before, to the best of our knowledge, there are no such reports on kushenols A and I. Therefore, this study represents the first report of their estrogenic activity. |
| التعليقات: | Comment on: PLoS One. 2022 Aug 17;17(8):e0273164. doi: 10.1371/journal.pone.0273164. (PMID: 35976950) |
| References: | PLoS One. 2013 Jul 12;8(7):e67947. (PMID: 23874474) Molecules. 2019 Dec 04;24(24):. (PMID: 31817093) Fitoterapia. 2020 Jun;143:104556. (PMID: 32194169) Evid Based Complement Alternat Med. 2019 Mar 13;2019:2673769. (PMID: 31001351) Phytomedicine. 2011 Jul 15;18(10):868-72. (PMID: 21377852) Phytochemistry. 2003 Apr;62(7):1093-9. (PMID: 12591262) J Biol Chem. 1997 Feb 7;272(6):3280-8. (PMID: 9013566) J Nutr Biochem. 2023 Apr;114:109250. (PMID: 36509337) J Steroid Biochem Mol Biol. 2010 Jan;118(1-2):1-6. (PMID: 19733663) Crit Rev Food Sci Nutr. 2022;62(18):5067-5080. (PMID: 33543993) J Nutr Biochem. 2020 Dec;86:108486. (PMID: 32827666) Front Pharmacol. 2021 Sep 27;12:737137. (PMID: 34646138) J Nat Prod. 2004 Nov;67(11):1829-32. (PMID: 15568770) Curr Med Chem. 2013;20(2):272-9. (PMID: 23244581) J Ethnopharmacol. 2015 Aug 22;172:10-29. (PMID: 26087234) Biol Pharm Bull. 2008 Jan;31(1):154-8. (PMID: 18175961) Sci Rep. 2014 Dec 08;4:7355. (PMID: 25483453) Pharm Biol. 2014 May;52(5):655-60. (PMID: 24256182) Planta Med. 2005 Nov;71(11):1065-8. (PMID: 16320211) J Clin Microbiol. 2005 Jul;43(7):3574-5. (PMID: 16000511) Cancer Med. 2023 Jan;12(2):1643-1654. (PMID: 35789211) Phytochemistry. 2021 Nov;191:112895. (PMID: 34403885) Phytother Res. 2019 Mar;33(3):546-560. (PMID: 30652369) Phytomedicine. 2022 Jun;100:154054. (PMID: 35358931) Arch Biochem Biophys. 2014 Oct 1;559:12-6. (PMID: 24736381) Environ Int. 2015 Oct;83:11-40. (PMID: 26073844) Steroids. 1995 May;60(5):383-94. (PMID: 7570711) Sci Rep. 2021 Apr 1;11(1):7388. (PMID: 33795823) J Agric Food Chem. 2020 Sep 30;68(39):10651-10663. (PMID: 32945668) Molecules. 2016 Jul 29;21(8):. (PMID: 27483227) Environ Toxicol. 2002 Feb;17(1):14-23. (PMID: 11847970) PLoS One. 2022 Aug 17;17(8):e0273164. (PMID: 35976950) Trends Endocrinol Metab. 2019 Jan;30(1):66-76. (PMID: 30527917) Fitoterapia. 2015 Jun;103:71-82. (PMID: 25771121) Arch Pharm Res. 2005 Feb;28(2):190-4. (PMID: 15789750) Environ Pollut. 2011 Jan;159(1):212-218. (PMID: 20875696) Biosci Biotechnol Biochem. 2018 Feb;82(2):207-215. (PMID: 29307271) Oxid Med Cell Longev. 2022 Jan 18;2022:3260243. (PMID: 35087614) J Enzyme Inhib Med Chem. 2018 Dec;33(1):1048-1054. (PMID: 29873272) |
| معلومات مُعتمدة: | 20H04343 Kakenhis; 23K11443 Kakenhis |
| فهرسة مساهمة: | Keywords: cell signaling pathway; estrogen response; estrogenic activity; gene expression; prenylated flavonoid |
| المشرفين على المادة: | 0 (Flavonoids) 0 (Plant Extracts) 2DI9HA706A (Estrone) |
| تواريخ الأحداث: | Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240615 |
| رمز التحديث: | 20240616 |
| مُعرف محوري في PubMed: | PMC10887985 |
| DOI: | 10.3390/genes15020204 |
| PMID: | 38397194 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2073-4425 |
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| DOI: | 10.3390/genes15020204 |