دورية أكاديمية
Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
| العنوان: | Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety. |
|---|---|
| المؤلفون: | Iida I; Division of Oral Biochemistry, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan.; Research Center for Advanced Oral Science, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan.; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, 153-8902, Japan., Konno K; Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, 060-8638, Japan., Natsume R; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan., Abe M; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan., Watanabe M; Department of Anatomy, Faculty of Medicine, Hokkaido University, Sapporo, 060-8638, Japan., Sakimura K; Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, 951-8585, Japan. sakimura@bri.niigata-u.ac.jp., Terunuma M; Division of Oral Biochemistry, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Niigata University, Niigata, 951-8514, Japan. mterunuma@dent.niigata-u.ac.jp. |
| المصدر: | Scientific reports [Sci Rep] 2024 Feb 24; Vol. 14 (1), pp. 4521. Date of Electronic Publication: 2024 Feb 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Receptors, Kainic Acid*/genetics , Receptors, Kainic Acid*/metabolism , GluK3 Kainate Receptor*, Mice ; Animals ; Humans ; Mice, Inbred C57BL ; Receptors, Ionotropic Glutamate ; Anxiety/genetics |
| مستخلص: | Kainate receptors (KARs) are one of the ionotropic glutamate receptors in the central nervous system (CNS) comprised of five subunits, GluK1-GluK5. There is a growing interest in the association between KARs and psychiatric disorders, and there have been several studies investigating the behavioral phenotypes of KAR deficient mice, however, the difference in the genetic background has been found to affect phenotype in multiple mouse models of human diseases. Here, we examined GluK1-5 single KO mice in a pure C57BL/6N background and identified that GluK3 KO mice specifically express anxiolytic-like behavior with an alteration in dopamine D2 receptor (D2R)-induced anxiety, and reduced D2R expression in the striatum. Biochemical studies in the mouse cortex confirmed that GluK3 subunits do not assemble with GluK4 and GluK5 subunits, that can be activated by lower concentration of agonists. Overall, we found that GluK3-containing KARs function to express anxiety, which may represent promising anti-anxiety medication targets. (© 2024. The Author(s).) |
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| معلومات مُعتمدة: | JP17K14960 Japan Society for the Promotion of Science; JP18K06813 Japan Society for the Promotion of Science; JP16H06276 Japan Society for the Promotion of Science; JP17H04372G Japan Society for the Promotion of Science |
| المشرفين على المادة: | 0 (Receptors, Kainic Acid) 0 (GluK3 Kainate Receptor) 0 (Receptors, Ionotropic Glutamate) |
| تواريخ الأحداث: | Date Created: 20240224 Date Completed: 20240226 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| مُعرف محوري في PubMed: | PMC10894277 |
| DOI: | 10.1038/s41598-024-55063-z |
| PMID: | 38402313 |
| قاعدة البيانات: | MEDLINE |
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